Murine FcγRII and III in Mast Cell Activation

Daëron, Marc; Latouru, Sylvain; Hückel, C; Bonnerot, Christian; Fridman, Wolf Herman

doi:10.1016/s0171-2985(11)80638-8

Cited by 8 publications

(1 citation statement)

References 51 publications

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“…1I). To our knowledge, this is the first report of human mast cell surface Fc␥RIII expression, although Fc␥RIII mRNA has been detected in human CD34ϩ cultured mast cells [5], and surface expression has been observed on murine mast cells [24]. MFI values of surface Fc␥RI, Fc␥RII, and Fc␥RIII on CBMC were 7 Ϯ 6%, 8 Ϯ 6%, and 5 Ϯ 3.5%, respectively.…”

Section: Fcr Expression On Mast Cellsmentioning

confidence: 73%

A dominant role for FcγRII in antibody-enhanced dengue virus infection of human mast cells and associated CCL5 release

Brown

King

Sherren

et al. 2006

Journal of Leukocyte Biology

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Dengue virus is a major mosquito-borne human pathogen with four known serotypes. The presence of antidengue virus antibodies in the serum of individuals prior to dengue virus infection is believed to be an important risk factor for severe dengue virus disease as a result of the phenomenon of antibody-dependent enhancement operating on Fc receptor (FcR)-bearing cells. In addition to blood monocytes, mast cells are susceptible to antibody-enhanced dengue virus infection, producing a number of inflammatory mediators including IL-1, IL-6, and CCL5. Using the human mast cell-like lines KU812 and HMC-1 as well as primary cultures of human cord blood-derived mast cells (CBMC), we aimed to identify the participating FcRs in antibody-enhanced mast cell dengue virus infection, as FcRs represent a potential site for therapeutic intervention. CBMC expressed significant levels of FcgammaRI, FcgammaRII, and FcgammaRIII, and mast cell-like HMC-1 and KU812 cells expressed predominantly FcgammaRII. All four serotypes of dengue virus showed antibody-enhanced binding to KU812 cells. Specific FcgammaRII blockade with mAb IV.3 was found to significantly abrogate dengue virus binding to KU812 cells and CBMC in the presence of dengue-specific antibody. Dengue virus infection and the production of CCL5 by KU812 cells were also inhibited by FcgammaRII blockade.

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Section: Fcr Expression On Mast Cellsmentioning

confidence: 73%

A dominant role for FcγRII in antibody-enhanced dengue virus infection of human mast cells and associated CCL5 release

Brown

King

Sherren

et al. 2006

Journal of Leukocyte Biology

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Fc Receptor Phagocytosis

Worth

Schreiber

Molecular Mechanisms of Phagocytosis

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Functional expression in mast cells of chimeric receptors with antibody specificity

et al. 1994

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Chimeric genes composed of a single-chain Fv domain (scFv) of an antibody linked with receptor chains normally present in cells of hematopoietic origin were constructed. Such genes could be expressed as functional surface receptors in the RBL-2H3 (rat basophilic leukemia) mast cell line. The chimeric receptors exhibited binding properties of an antibody molecule and triggered degranulation of transfected mast cells on stimulation with antigen. Genetically engineered designer cells (e.g., T-lymphocytes, mast cells, or natural killer cells), equipped with built-in antibody-type recognition, can be now exploited for immunotherapy.

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Murine FcγRII and III in Mast Cell Activation

Cited by 8 publications

References 51 publications

A dominant role for FcγRII in antibody-enhanced dengue virus infection of human mast cells and associated CCL5 release

A dominant role for FcγRII in antibody-enhanced dengue virus infection of human mast cells and associated CCL5 release

Fc Receptor Phagocytosis

Functional expression in mast cells of chimeric receptors with antibody specificity

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