Murine experimental models for studying the pathogenesis of coxsackieviruses

Abstract

Understanding the pathogenesis of communicable diseases often involves animal models. Mouse models are studied by researchers to achieve a better understanding of the relationship between the biological, physiochemical, and antigenic properties of the infectious agent, as well as the histopathological, immunological, and functional changes in the living system and the target organs, in short, the pathophysiological processes that the communicable agents bring about. The long-term objectives of the in vivo studies are important from a medical point of view, as they represent faithful (reliable and similar) human responses, which enhance the development of diagnostics, treatment, and measures for preventing the spread of the disease. Our work is devoted to the murine models used for understanding the pathogenesis of coxsackieviruses. We describe different mouse models used for studying the diseases caused by coxsackieviruses and the immune responses in different mouse models. We then shortly elucidate experiences from our laboratory related to the oral route of infection, and compare the similarities and differences we found in this model.

Coxsackievirus B4 sewage-isolate induces pancreatitis after oral infection of mice

“…Mice are not the natural hosts of human EVs, yet they are good models for studying the pathogenesis of CVs (Bopegamage et al . 2020 ). In the present study, we demonstrated differences between clinical isolates collected from a seriously ill aseptic meningitis patient, and an isolate from a treated-sewage sample recovered from a regional municipal sewage treatment plant allocated to the residential area of the patient.…”

Introduction

“…Studies aimed at understanding virus pathogenesis at the level of organism require proper virus and host models in vivo. This special issue of Acta virologica includes two articles describing muride herpersvirus 4 (MHV-4) as a model for research of human oncogenic gammaherpesviruses (Mistríková and Briestenská, 2020) and mice as experimental models for studying coxackieviruses (Bopegamage et al, 2020).…”