Murine double minute 2 rs2279744 polymorphism and hepatocellular carcinoma risk in East Asians: a meta-analysis

Abstract

Murine double minute 2 (MDM2) is a crucial negative regulator of p53 function through several mechanisms. There are many studies performed to assess the association between MDM2 rs2279744 polymorphism and hepatocellular carcinoma risk, but the impact of MDM2 rs2279744 polymorphism on hepatocellular carcinoma in East Asians is unclear owing to the inconsistent findings from previous studies. We conducted a comprehensive meta-analysis of epidemiological studies to shed some light on these contradicting results. We used pooled odds ratio (OR) with its 95 % confidence intervals (95 % CI) to assess the association. Overall, seven studies with a total of 4,993 subjects were finally included. The meta-analysis suggested that MDM2 rs2279744 polymorphism was significantly associated with increased risk of hepatocellular carcinoma in East Asians (G versus T: OR = 1.27, 95 % CI 1.06-1.52, P = 0.01; GG versus TT: OR = 1.59, 95 % CI 1.11-2.27, P = 0.01; GG/GT versus TT: OR = 1.41, 95 % CI 1.07-1.87, P = 0.02; GG versus TT/GT: OR = 1.32, 95 % CI 1.08-1.62, P = 0.008). Sensitivity analysis by excluding low-quality study still suggested that the association above was still significant. Thus, the findings from the meta-analysis support that MDM2 rs2279744 polymorphism is significantly associated with increased risk of hepatocellular carcinoma in East Asians.

Current evidence on the relationship between murine double minute 2 T309G polymorphism and esophageal cancer susceptibility

“…Also, Liu et al . concluded that the variant allele 309G was associated with a significantly increased risk of hepatocellular carcinoma in East Asians, which is similar with our current finding . Interestingly, Chen et al .…”

“…As expected, this presumption was proved by our further investigations, which demonstrated that the G allele of MDM2 SNP309 was positively associated with increased EC risk. Many investigators also have reported similar observations in other cancers . Recently, Qin and colleagues found that the MDM2 SNP309 polymorphism might contribute to colorectal cancer risk, especially in Asian populations .…”

“…25 Also, Liu et al concluded that the variant allele 309G was associated with a significantly increased risk of hepatocellular carcinoma in East Asians, which is similar with our current finding. 26 Interestingly, Chen et al 31 and Yang et al 32 confirmed that the MDM2 309G variant was significantly associated with a decreased prostate cancer risk. We believe that the inconsistent results could be explained by the following points.…”

“…Many investigators also have reported similar observations in other cancers. [25][26][27][28][29][30] Recently, Qin and colleagues found that the MDM2 SNP309 polymorphism might contribute to MDM2 SNP 309 and esophageal cancer risk 597 colorectal cancer risk, especially in Asian populations. 25 Also, Liu et al concluded that the variant allele 309G was associated with a significantly increased risk of hepatocellular carcinoma in East Asians, which is similar with our current finding.…”

Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma

“…MDM2 SNP309 plays a major role in the carcinogenesis of HCC, especially among Caucasian populations [29]. The findings from different areas support that MDM2 is significantly associated with increased risk of hepatocellular carcinoma [32–35]. MDM2 SNP309 G allele is a susceptibility gene for the development of viral hepatitis-related hepatocellular carcinoma [36–38].…”