Murine and human mast cell progenitors

Schmetzer, Oliver; Valentin, Patricia; Church, Martin K.; Maurer, Marcus; Siebenhaar, Frank

doi:10.1016/j.ejphar.2015.07.016

Cited by 31 publications

(22 citation statements)

References 75 publications

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“…In all organs, differentiation and proliferation of resident mast cells are driven by SCF (also named KIT Ligand) which is synthesized and released by cells of the host tissue (Schmetzer et al, 2016). We found that, in the fetal adrenal, SCF mRNA could be detected from the first fetal stage studied, i.e.…”

Section: Mast Cells In the Human Fetal Adrenal Glandmentioning

confidence: 95%

Temporal and spatial distribution of mast cells and steroidogenic enzymes in the human fetal adrenal

Naccache

Louiset

Duparc

et al. 2016

Molecular and Cellular Endocrinology

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Section: Mast Cells In the Human Fetal Adrenal Glandmentioning

confidence: 95%

Temporal and spatial distribution of mast cells and steroidogenic enzymes in the human fetal adrenal

Naccache

Louiset

Duparc

et al. 2016

Molecular and Cellular Endocrinology

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“…Studies in mice suggest they come from granulocyte/monocyte progenitors downstream of common myeloid progenitors . To make matters more complicated, distinct developmental pathways and tissue microenvironments govern MC phenotypes, ie, tryptase‐positive (MC T ) and tryptase/chymase‐positive (MC TC ) …”

Section: Origin and Developmentmentioning

confidence: 99%

“…11 Another protein necessary for eosinophil granularity and survival in mice is cystatin F. 12 In MCs, GATA-1 and GATA-2 drive differentiation and regulate transcription of FcεRI and KIT genes. 3 PU.1 also promotes MC development, but expression becomes weaker as MCs mature. 9 Similar to eosinophils, FOG-1 inhibits MC differentiation, redirecting progenitors toward other cell lineages.…”

Section: Differentiation and Maturationmentioning

confidence: 99%

Human eosinophils and mast cells: Birds of a feather flock together

Robida

Puzzovio

Pahima

et al. 2018

Immunological Reviews

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While the origin of the phrase "birds of a feather flock together" is unclear, it has been in use for centuries and is typically employed to describe the phenomenon that people with similar tastes or interests tend to seek each other out and congregate together. In this review, we have co-opted this phrase to compare innate immune cells of related origin, the eosinophil and mast cell, because they very often accumulate together in tissue sites under both homeostatic and inflammatory conditions. To highlight overlapping yet distinct features, their hematopoietic development, cell surface phenotype, mediator release profiles and roles in diseases have been compared and contrasted. What emerges is a sense that these two cell types often interact with each other and their tissue environment to provide synergistic contributions to a variety of normal and pathologic immune responses.

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“…Commonly, toluidine blue staining of granules is the method used for the identification and quantification of mast cells in most tissues (29,30), but it is not always possible to detect fully degranulated mast cells with this technique (31). Alternately, CD117, which is a mast/stem cell grown factor receptor (SCFR) found in the membrane of mast cells, had been targeted to determinate activated mast cell in several tissues, including degranulated mast cells in the gastrointestinal mucosa (32,33).…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte subpopulations and mast cells intestinal changes as indicators of inflammatory bowel disease in dogs

Espinoza-Zambrano

González

2019

Preprint

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13 Inflammatory bowel disease (IBD) is a disease with recurring 14 gastrointestinal symptoms. Lymphocytes and mast cells are proposed as 15 important components in the immunopathology of IBD in dogs. Mast cells 16 depend on degranulation, a process that compromises mucosal 17 permeability and normal intestinal barrier function, which alters the normal 18 inflammatory process by allowing recruitment of lymphocytes in dogs with 19 IBD. In this study, T and B lymphocyte populations and mast cells were 20 examined in situ in 39 intestinal samples of dogs affected by IBD, by 2 21 immunohistochemistry. Both T lymphocytes and mast cells numbers were 22 significantly higher in the lamina propria of the intestinal wall of dogs with 23 IBD compared with control dogs. Out of the total number of mast cells 24 detected by CD117 expression significantly less cells appear to be 25 granulated according to granule staining with Toluidine Blue, suggesting 26 that an important degranulation process takes place in IBD. Single and 27 double immune staining for tryptase and chymase showed that mast cells 28 can express only one or both enzymes. Tryptase positive cells were 29 significantly higher in number that chymase positive and 30 tryptase/chymase positive cells. T lymphocytes were concentrated mostly 31 at the upper portion of the intestinal villi lamina propria while mast cells 32 were distributed mainly among crypts. These results suggest that 33 populations of T lymphocytes and mast cells play a role in the 34 immunopathology and development of IBD in dogs, also these changes 35 could be helpful as complementary indicators of canine IBD. 36 37 Keywords: dog; inflammatory bowel disease; immunohistochemistry; T 38 lymphocytes; mast cells 39 40 42 disorders characterized by persistent or recurring gastrointestinal 43 symptoms with histologic evidence of inflammatory cell infiltration (1). 3 44 There are different forms of IBD in dogs, depending on the main cell type 45 involved and the affected portion of the intestine where the infiltration 46 takes place, being lymphocytic-plasmacytic enteritis the most common 47 form (2). The etiology of IBD remains unknown. Several studies suggest 48 that these diseases result from inappropriate immune responses to the 49 intestinal microbiome in genetically susceptible individuals (3-6). There 50 are several factors involved including microbiome, environmental factors, 51 genetic predisposition, and changes in the immune response of the 52 individual, which may lead to loss of tolerance to the endogenous flora 53 and the development of chronic inflammation of the gastrointestinal tract 54 (7,8). 55 Different studies (9-12) suggest that a primary defect in the 56 recognition of commensal bacteria or bacterial pathogens in the intestinal 57 lumen, may lead to an increase in the production of IL-23, that induce 58 naïve T cells to differentiate into T-helper (Th) lymphocytes, which release 59 large amounts of proinflammatory cytokines (13,14). Theses cytokines 60 damage the intestinal epitheliu...

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Murine and human mast cell progenitors

Cited by 31 publications

References 75 publications

Temporal and spatial distribution of mast cells and steroidogenic enzymes in the human fetal adrenal

Temporal and spatial distribution of mast cells and steroidogenic enzymes in the human fetal adrenal

Human eosinophils and mast cells: Birds of a feather flock together

Lymphocyte subpopulations and mast cells intestinal changes as indicators of inflammatory bowel disease in dogs

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