Mural repair following obliteration of aneurysms: Production of experimental aneurysms

Young, Paul H.; Fischer, Vernon W.; Guity, Afrassiab; Young, Paul A.

doi:10.1002/micr.1920080306

Cited by 14 publications

(7 citation statements)

References 20 publications

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“…Growth and/or rupture of experimental aneurysms were found in three types of models: sidewall (n = 12) [3,8,[13][14][15][16][17][18][19][20][21][22], bifurcation stump (n = 6) [14,[23][24][25][26][27], and terminal (n = 3) [28][29][30]. Most frequent growth was reported in rats (n = 6) [8,14,16,[23][24][25], followed by rabbits (n = 4) [13,21,26,29], dogs (n = 4) [19,27,28,30], swine (n = 5) [3,17,18,20,22], and sheep (n = 1) [15]. Except for two studies reporting growth and rupture within the abdominal cavity (abdominal aortic artery; n = 2) [8,16] all other aneurysms were located at the neck of the animal (common carotid artery; n = 18).…”

Section: Resultsmentioning

confidence: 99%

“…Except for two studies reporting growth and rupture within the abdominal cavity (abdominal aortic artery; n = 2) [8,16] all other aneurysms were located at the neck of the animal (common carotid artery; n = 18). The identified 20 models used in n = 14 venous pouches (in n = 2 of them inverted venous pouches [3,30]), in n = 3 modified arterial pouches (n = 2 porcine elastase [26,29] and n = 1 sodium dodecyl sulfate [8]), and in n = 3 direct mechanical arterial wall weakening [13,23,24] to create growing and rupture-prone aneurysms. Time for aneurysm creation was reported in only two studies (180 minutes each for a terminal model in dogs [28] and rabbits [29]).…”

Section: Resultsmentioning

confidence: 99%

“…Almost half (n = 9 out of 20) of the models demonstrated growth only without associated rupture during follow-up. The volume increase varied greatly between the models used and ranged between tiny blebs [23] and a 10-fold increase [8] in initial size. Most models (n = 17 out of 20) reported only modest increase, with stabilization at further follow-up.…”

Section: Resultsmentioning

confidence: 99%

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Saccular Aneurysm Models Featuring Growth and Rupture: A Systematic Review

et al. 2020

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Background. Most available large animal extracranial aneurysm models feature healthy non-degenerated aneurysm pouches with stable long-term follow-ups and extensive healing reactions after endovascular treatment. This review focuses on a small subgroup of extracranial aneurysm models that demonstrated growth and potential rupture during follow-up. Methods. The literature was searched in Medline/Pubmed to identify extracranial in vivo saccular aneurysm models featuring growth and rupture, using a predefined search strategy in accordance with the PRISMA guidelines. From eligible studies we extracted the following details: technique and location of aneurysm creation, aneurysm pouch characteristics, time for model creation, growth and rupture rate, time course, patency rate, histological findings, and associated morbidity and mortality. Results. A total of 20 articles were found to describe growth and/or rupture of an experimentally created extracranial saccular aneurysm during follow-up. Most frequent growth was reported in rats (n = 6), followed by rabbits (n = 4), dogs (n = 4), swine (n = 5), and sheep (n = 1). Except for two studies reporting growth and rupture within the abdominal cavity (abdominal aortic artery; n = 2) all other aneurysms were located at the neck of the animal. The largest growth rate, with an up to 10-fold size increase, was found in a rat abdominal aortic sidewall aneurysm model. Conclusions. Extracranial saccular aneurysm models with growth and rupture are rare. Degradation of the created aneurysmal outpouch seems to be a prerequisite to allow growth, which may ultimately lead to rupture. Since it has been shown that the aneurysm wall is important for healing after endovascular therapy, it is likely that models featuring growth and rupture will gain in interest for preclinical testing of novel endovascular therapies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Saccular Aneurysm Models Featuring Growth and Rupture: A Systematic Review

et al. 2020

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“…Previous experiments showed that external mural excision of the adventitia of the common carotid artery developed aneurysmal lesions in two thirds of rats, but selective removal of the media failed to develop aneurysmal lesions in the chronic stage. 29) Elastase produces aneurysms, but collagenase causes the rupture of blood vessels without protrusion. 8) Therefore, collagenase is essential for injuring the adventitia of the arterial wall whereas only elastase is not sufficient.…”

Section: Discussionmentioning

confidence: 99%

Rabbit Aneurysm Model Mediated by the Application of Elastase

Sasaki

Ujiié

Higa

et al. 2004

Neurol. Med. Chir.(Tokyo)

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The concentrations and application methods of elastase in the rabbit aneurysm model were optimized to control the initiation of aneurysms and to cause rupture in a stepwise, controlled fashion. The common carotid artery of male Japanese albino rabbits was exposed. No aneurysm was generated if the adventitia was not dissected. After gentle removal of the adventitia, a two-fold dilution series of elastase was applied to the lesion and observed over a period of 2 hours. Various stages of aneurysmal lesions, from spindle-shaped enlargement to rupture, were produced in proportion to the elastase concentration. Application of elastase stock solution (5 U/mg of type I porcine pancreatic elastase) resulted in rupture within 30 minutes in all six animals. Elastase 1:2 solutions caused oozing in all animals, but subsequent rupture in only three of six animals. Histological examination found serious destruction of the internal elastic lamina and media, with expansion of the very thin wall. Elastase 1:4 to 1:16 solutions caused spindle-like distention of the entire artery and the development of tortuosity at the lesion. Elastase 1:32 or weaker solutions caused only localized dilatations. Overall, the destruction of the tunica media became less severe with decreased elastase concentration. Furthermore, the bursting pressure of the aneurysms decreased with increasing elastase concentrations. In particular, aneurysms produced by the elastase 1:2 solution ruptured at less than 150 mmHg, whereas aneurysms induced by the elastase 1:4 or weaker solutions did not rupture within the physiological range of blood pressure. The present aneurysm model requires shorter preparation time and enables accurate control of aneurysm development and rupture.

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“…In delivering elastase topically to the bifurcation of either the right CCA or the right superior thyroid artery bifurcation, Miskolczi et al 59 found that aneurysm formation was mainly at the latter location. Nishikawa et al 60 and Young et al 61 induced natural bifurcation models in rats by suturing a vein pouch or inducing external damage to the vessel wall at the site of CCA/ECA bifurcation.…”

Section: Bifurcation Aneurysm Model Natural and Artificial Variationsmentioning

confidence: 99%

Preclinical extracranial aneurysm models for the study and treatment of brain aneurysms: A systematic review

Marbacher

Strange

Frösén

et al. 2020

J Cereb Blood Flow Metab

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Animal models make an important contribution to our basic understanding of the pathobiology of human brain aneurysms, are indispensable in testing novel treatment approaches, and are essential for training interventional neuroradiologists and neurosurgeons. Researchers are confronted with a broad diversity of models and techniques in various species. This systematic review aims to summarize and categorize extracranial aneurysm models and their characteristics, discuss advantages and disadvantages, and suggest the best use of each model. We searched the electronical Medline/PubMed database between 1950 and 2020 to identify main models and their refinements and technical modifications for creation of extracranial aneurysms. Each study included was assessed for aneurysm-specific characteristics, technical details of aneurysm creation, and histological findings. Among more than 4000 titles and abstracts screened, 473 studies underwent full-text analysis. From those, 68 different techniques/models in five different species were identified, analyzed in detail, and then grouped into one of the five main groups of experimental models as sidewall, terminal, stump, bifurcation, or complex aneurysm models. This systematic review provides a compact guide for investigators in selecting the most appropriate model from a range of techniques to best suit their experimental goals, practical considerations, and laboratory environment.

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Mural repair following obliteration of aneurysms: Production of experimental aneurysms

Cited by 14 publications

References 20 publications

Saccular Aneurysm Models Featuring Growth and Rupture: A Systematic Review

Saccular Aneurysm Models Featuring Growth and Rupture: A Systematic Review

Rabbit Aneurysm Model Mediated by the Application of Elastase

Preclinical extracranial aneurysm models for the study and treatment of brain aneurysms: A systematic review

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