Mupirocin-Resistant Staphylococcus Aureus

Rahman, Mary; Noble, W. C.; Cookson, Barry; Baird, Dugald; Coia, John

doi:10.1016/s0140-6736(87)92398-1

Cited by 152 publications

(70 citation statements)

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“…The latter treatment was recently adopted as a control measure against MRS A infections (3, 5). However, cases with mupirocin-resistant MRSA have already been reported (12,14). Accordingly, we suggest preoperative use of intranasal mupirocin ointment in such patients as undergoing upper gastrointestinal surgery, but we must be careful in extensive or long-term use of that.…”

Section: Discussionmentioning

confidence: 97%

Enterocolitis Caused by Methicillin‐Resistant Staphylococcus aureus: Molecular Characterization of Respiratory and Digestive Tract Isolates

Watanabe

Masaki

Asoh

et al. 2001

Microbiology and Immunology

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Abstract:We investigated the mechanism of outbreak of enterocolitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Five epidemiological markers [coagulase type, enterotoxin type, toxic shock syndrome toxin-l (TSST-l) production, ll-Iactamase production and pulsed-field gel electrophoresis (PFGE)] of 45 strains of MRSA isolated simultaneously from the respiratory tract (nasal cavity and/or pharynx and/or sputum) and stool (plus one sample of gastric juice) in 13 patients (8 males and 5 females, mean age, 77.1 years) were compared retrospectively. Forty-four of the 45 isolates of MRSA were positive for enterotoxin C and TSST-l production, and the remaining isolate was positive for enterotoxin A and negative for TSST-l production. All isolates were coagulase type II, and 27 showed ll-Iactamase production. The patterns of coagulase type, enterotoxin type, TSST-l and ll-Iactamase production of MRSA isolated from the respiratory tract were similar to those of MRSA isolated from the intestine in 12 of 13 patients. Molecular typing by PFGE demonstrated that the pattern of respiratory tract isolates was identical to those of stool isolates in 9 (69.2%), similar in 3 (23.1%), and different in 1 (7.7%). The data suggested that enterocolitis might be caused by the MRSA colonized in the respiratory tract and incorporated into the digestive tracts. Therefore, we propose that early eradication of MRSA in the respiratory tract is important for protection of patients against the development of enterocolitis, particularly in susceptible patients, e.g., immunocompromised or pre-operated patients with digestive diseases, especially malignant disease.

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Section: Discussionmentioning

confidence: 97%

Enterocolitis Caused by Methicillin‐Resistant Staphylococcus aureus: Molecular Characterization of Respiratory and Digestive Tract Isolates

Watanabe

Masaki

Asoh

et al. 2001

Microbiology and Immunology

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“…Early studies showed that low level resistance mg/l) could be selected by repeated subculture of staphylococci in the presence of the antibiotic (White et al 1985). However, in 1987 we observed and reported (Rahman, Noble & Cookson, 1987) high level mupirocin resistance in Staphylococcus aureus isolated from patients in the dermatology wards at our hospital. Others have also reported high level resistance (Smith & Kennedy, 1988).…”

Section: Introductionmentioning

confidence: 83%

Transmissible mupirocin resistance inStaphylococcus aureus

1989

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SUMMARYThe spread of two strains of Staphylococcus aureus with high level resistance to mupirocin is described. The resistance proved to be easily transferred to other S. aureus strains by filter mating experiments and on the skin of mice. No plasmid band corresponding to the resistance could be demonstrated by agarose gel electrophoresis or by caesium chloride gradient centrifugation but cleavage of 'chromosomal' DNA from resistant recipients showed bright bands of DNA absent from sensitive controls.

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“…Mupirocin resistance was described shortly after it became available (8,11). Prevalence of mupirocin resistance among MRSA isolates has been described mostly in hospitalized adult and elderly patients with wide variability, ranging from 0 to 65% of isolates (2, 4-7, 9, 10, 12-14, 16-19).…”

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confidence: 99%