Municipal leachates health risks: Chemical and cytotoxicity assessment from regulated and unregulated municipal dumpsites in Lebanon

Khalil, Christian; Hageh, Cynthia Al; Korfali, Samira Ibrahim; Khnayzer, Rony S.

doi:10.1016/j.chemosphere.2018.05.151

Cited by 52 publications

(25 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings indicate that 98% of the sulfate was removed in all reactors by the end of the study. Similar findings are reported in the literature [3,34].…”

Section: Chloride and Sulfatesupporting

confidence: 93%

“…Final TDS concentrations were 17.4, 16.77, 15.32, and 13.34 mg L −1 for R1, R2, R3, and R4, respectively. Similar TDS values were reported in literature [3,42,44].…”

Section: Tds and Conductivitysupporting

confidence: 92%

“…Landfill, preceded by separation and recovery, can be the most suitable waste management method for developing countries [1]. The common problems associated with managing MSW result from poor implementation of waste segregation at source, low operational efficiency of waste transport systems, environmental and health risks of the leachate and inefficient recycling systems [2][3][4]. In many developing countries, financial restrictions and inadequate regulations or their inadequate enforcement can lead to poor planning or operation of MSW management [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Improvement of leachate quality and waste stabilization in pilot-scale bioreactor landfills containing geotextile filters and sewage sludge

Yaman¹

2019

Desalination and Water Treatment

View full text Add to dashboard Cite

In many developing countries, there has been growing interest in bioreactor landfills for municipal solid waste (MSW) management. This research study has been conducted for comparing leachate characterization and waste stabilization in simulated pilot-scale anaerobic bioreactor landfills. Four pilot-scale reactors were constructed and operated for 540 d. This study aimed to show whether a pilot-scale bioreactor containing sewage sludge mixed with MSW, with a geotextile filter in its drainage layer, and with recirculating leachate, could improve leachate quality and waste stabilization in a landfill. Bioreactor R1 comprised MSW and sewage sludge, while bioreactor R2 was the same as R1 but with a geotextile-1 (GT-1) filter fitted. R3 contained no sludge but only MSW and GT-1 fitted, while R4 contained no sludge but only MSW and two layers of geotextile filter (GT-2 and GT-3). All reactors were operated with leachate recirculation, simulating bioreactor landfills. The results showed that the chemical oxygen demand (COD) half-lives of leachate from the reactors were approximately 8, 7, 9, and 10 months for R1, R2, R3, and R4, respectively. By the end of the study, the waste in R2 and R4 was more stable, with 66% and 65% reductions in volatile solids, respectively. Reactor R2, which contained MSW, sewage sludge, and one-layer geotextile (GT-1), provided higher stabilization of MSW and shorter COD half life than the other reactors.

show abstract

“…The findings indicate that 98% of the sulfate was removed in all reactors by the end of the study. Similar findings are reported in the literature [3,34].…”

Section: Chloride and Sulfatesupporting

confidence: 93%

“…Final TDS concentrations were 17.4, 16.77, 15.32, and 13.34 mg L −1 for R1, R2, R3, and R4, respectively. Similar TDS values were reported in literature [3,42,44].…”

Section: Tds and Conductivitysupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Improvement of leachate quality and waste stabilization in pilot-scale bioreactor landfills containing geotextile filters and sewage sludge

Yaman¹

2019

Desalination and Water Treatment

View full text Add to dashboard Cite

show abstract

“…63 Earlier reports have reported that exposure to leachate induces significant DNA damage in different cell types. [64][65][66] Interestingly, findings of our study also indicated that leachate-induced mitochondrial dysfunction may induce a pro-inflammatory state. In comparison to the controls, the levels of NF-κβ were significantly higher among the cells exposed to the landfill leachate, while significantly higher secreted levels of pro-inflammatory cytokines TNFα, IL-6, and IFN-ƴ were observed in the culture supernatant of landfill leachate exposed cells as compared with their respective controls ( Figure 5).…”

Section: Discussionsupporting

confidence: 58%

Impairment of Mitochondrial-Nuclear Cross Talk in Lymphocytes Exposed to Landfill Leachate

Gupta

Bhargava

Kumari

et al. 2019

Environ�Health�Insights

View full text Add to dashboard Cite

Landfill leachate, a complex mixture of different solid waste compounds, is widely known to possess toxic properties. However, the fundamental molecular mechanisms engaged with landfill leachate exposure inducing cellular and sub-cellular ramifications are not well explicated. Therefore, we aim to examine the potential of leachate to impair mitochondrial machinery and its associated mechanisms in human peripheral blood lymphocytes. On assessment, the significant increase in the dichlorofluorescein (DCF) fluorescence, accumulation of 8-Oxo-2′-deoxyguanosine (8-oxo-dG), and levels of nuclear factor erythroid 2–related factor 2 (Nrf-2) strongly indicated the ability of the leachate to induce a pro-oxidant state inside the cell. The decrease in the mitochondrial membrane potential and alterations in the mitochondrial genome observed in leachate-exposed cells further suggested the disturbances in mitochondrial machinery. Moreover, these mitochondrial-associated redox imbalances were accompanied by the increased level of NF-κβ, pro-inflammatory cytokines, and DNA damage. In addition, the higher DNA fragmentation, release of nucleosomes, levels of polyadenosine diphosphate ADP-ribose polymerase (PARP), and activity of caspase-3 suggested the involvement of mitochondrial mediated apoptosis in leachate exposed cells. These observations were accompanied by the low proliferative index of the exposed cells. Conclusively, our results clearly indicate the ability of landfill leachate to disturb mitochondrial redox homeostasis, which might be a probable source for the immunotoxic consequences leading to plausible patho-physiological conditions in humans susceptible to such environmental exposures.

show abstract

“…Regarding with the major potential environmental impacts related to landfill, the main problem identified in the municipal wastes consisted of untreated leachates [59]. The leachate pollution of groundwater and surface waters can be categorized into four groups (dissolved organic matter, inorganic macrocomponents, heavy metals, and xenobiotic organic compounds) [60].…”

Section: Micronutrients and Trace Elements From Mswmentioning

confidence: 99%

The Use of Composted Municipal Solid Waste under the Concept of Circular Economy and as a Source of Plant Nutrients and Pollutants

Candel¹,

Pedreño²,

Lucas³

et al. 2019

Municipal Solid Waste Management

View full text Add to dashboard Cite

The European Union (EU) is one of the major producers of municipal solid wastes and has a common policy based on circular economy to reuse the wastes. However, there are differences between countries and the methods for disposal and treatments. Municipal solid waste (MSW) can be composted and recycled as a source of plant nutrients and improves soil properties. This chapter analyzed the production in the EU and the effects on plant nutrients and environmental pollutants when MSW is added to the soil. The origin of the waste and the compost-like output (CLO) derived is important to determine the expectative of nutrient availability and other possible risks. MSW is so heterogeneous, but after a good pretreatment, an organic-rich matter mix can be composted giving a stabilized organic matter. The addition of the CLO to the soils can improve the nutrient status and favor the bioavailability of nutrients (macronutrients and micronutrients). In general, an increment of N and P was found in the soils. Moreover, important micronutrient availability (Fe, Mn, Cu, and Zn) has been described. However, the presence of pollutants and their mobility should be considered as an environmental risk.

show abstract

Municipal leachates health risks: Chemical and cytotoxicity assessment from regulated and unregulated municipal dumpsites in Lebanon

Cited by 52 publications

References 70 publications

Improvement of leachate quality and waste stabilization in pilot-scale bioreactor landfills containing geotextile filters and sewage sludge

Improvement of leachate quality and waste stabilization in pilot-scale bioreactor landfills containing geotextile filters and sewage sludge

Impairment of Mitochondrial-Nuclear Cross Talk in Lymphocytes Exposed to Landfill Leachate

The Use of Composted Municipal Solid Waste under the Concept of Circular Economy and as a Source of Plant Nutrients and Pollutants

Contact Info

Product

Resources

About