Mumps prophylaxis in the light of a new test for antibody.

Mortimer, P P

doi:10.1136/bmj.2.6151.1523

Cited by 34 publications

(19 citation statements)

References 5 publications

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“…There is no sex difference. Analogous results were obtained in the United Kingdom (Mortimer, 1978). In the German Democratic Republic the incidence is maximal at the age of four to five years (Stelzner & Talaska, 1972).…”

Section: Introductionsupporting

confidence: 58%

Epidemiology of mumps in the Netherlands

Wagenvoort

Harmsen

Boutahar-Trouw

et al. 1980

J. Hyg.

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In a Dutch population group neutralizing antibodies against mumps virus were determined by a plaque reduction technique, which proved reproducible, sensitive and specific. The results with sera of about 800 suburban children show that mumps is acquired at an early age with peak acquisition rates between the ages of four and six years. Over 90% have acquired mumps before the age of 14 years. More than 95% of about 1000 adults (18--65 years) have neutralizing antibodies. The relatively constant median titre suggests that antibodies persist during life. During a family study 77 clinical and 18 subclinical cases were observed. In families with index cases the attack rate was 26/37 = 0.71. Eleven children (excluding six babies) escaped infection. The mean attack rate during the epidemic was 0.30. The mean titre of mumps neutralizing antibody is maximal during the first year after the disease but declines during childhood. Mothers exposed to mumps in the family occasionally showed a significant rise in titre. Some seronegative mothers remained seronegative after exposure.

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Section: Introductionsupporting

confidence: 58%

Epidemiology of mumps in the Netherlands

Wagenvoort

Harmsen

Boutahar-Trouw

et al. 1980

J. Hyg.

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“…1. Age related changes in the per capita force of infection (the rate at which susceptibles acquire infection per unit of time) derived from serological data collected in London and the Home Counties in 1977-8 (data from Mortimer, 1978). (a).…”

Section: Methods (A) Model Structurementioning

confidence: 99%

The epidemiology of mumps in the UK: a preliminary study of virus transmission, herd immunity and the potential impact of immunization

1987

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Mathematical models and statistical analyses of epidemiological data are employed to assess the potential impact of mass vaccination on the incidences of cases of mumps infection and cases of mumps related complications. The analyses reveal that in the United Kingdom the average age at infection with the mumps virus is currently between 6-7 years and that the inter-epidemic period of the infection is approximately 3 years. The critical level of vaccine uptake to eliminate mumps virus transmission is predicted to be approximately 85% of each cohort of boys and girls by the age of 2 years. Analyses of published data show that the risk of complication arising from mumps infection is markedly age- and sex-related. Model predictions suggest that the incidence of orchitis will be increased, over the level pertaining prior to mass vaccination, by levels of vaccine uptake (by 2 years of age) that are less than 70% of each yearly cohort of boys and girls. Moderate (over 60%) to high (75%) levels of vaccine uptake, however, are predicted to reduce the overall incidence of cases of mumps related complications (especially those with CNS involvement).

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“…1 suggests that this is a reasonable cut-off level for seropositivity; there are few false negatives (expected probability, p{ < ln 5 au} = 0-043). In subsequent analyses the small number of samples which gave visible zones of lysis corresponding to antibody levels of less than the 5 for males compared with females (T (pooled variance} =-2-46, 2-tail, P = 0-014, D.F. = 2132) (Fig.…”

Section: Serological Testmentioning

confidence: 99%

“…at one point in time), age-stratified serological surveys and provide the most appropriate base for assessing the levels of immunity in a population, and age-related changes in the acquisition of infection [3,4]. However, published surveys from the UK cover only a narrow spectrum of age classes [5], divide the subjects into too few groups by age [6] or lack information on antibody concentrations [5,6]. They are important in providing a qualitative picture of herd immunity, but have insufficient detail for further quantitative analyses.…”

mentioning

confidence: 99%

Serological study of the epidemiology of mumps virus infection in north-west England

et al. 1990

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SUMMARYSerum samples from individuals of a wide age range, collected in northwest England in 1984 and 1986, provide the basis for an analysis of the epidemiology of mumps virus infection. A radial haemolysis test yielding quantitative antibody measurements was used to screen samples for mumps-specific IgG. Analyses of resultant age-seroprevalence profiles, using statistical models, revealed an agerelated pattern in the rate of infection per susceptible similar to that observed for other childhood infections. This rate, or force of infection, was low in young children, high in older children, and low in adults. In addition, the serological surveys provide evidence for time-dependent changes (both epidemic and longerterm) in the rate of mumps virus transmission. The longer-term changes, reflected in the pattern of the age-acquisition of specific antibodies, are supported by evidence from case notification data. The implications of temporal changes in incidence to the interpretation and design of serological surveys are considered. TNTRODUJCTIONChanging circumstances surrounding mumps infection in this country provide good reason for further investigations aimed at improving our understanding of the epidemiology of this infection. The recent introduction of a triple measles, mumps and rubella (MMR) vaccine for the immunization of young children [1] has created an urgent need to assess the existing pattern of herd immunity (prior to

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Mumps prophylaxis in the light of a new test for antibody.

Cited by 34 publications

References 5 publications

Epidemiology of mumps in the Netherlands

Epidemiology of mumps in the Netherlands

The epidemiology of mumps in the UK: a preliminary study of virus transmission, herd immunity and the potential impact of immunization

Serological study of the epidemiology of mumps virus infection in north-west England

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