Mumps interstitial nephritis: a case report

Kabakuş, Nimet; Aydinoğlu, H; Bakkaloğlu, Sevcan A.; Yekeler, Hayrettin

doi:10.1007/s004670050731

Cited by 13 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, we described two cases of TIN, one related to hay fever immunotherapy and the second to immunostimulation with a multiantigenic bacterial mixture [8]. There are also reports of TIN(U) related to common viral infections such as mumps or adenovirus [9,10]. The occurrence of TINU in identical twins with a 1-year lapse between occurrences also suggests a genetic predisposition to autoimmune reaction [11].…”

Section: Discussionmentioning

confidence: 99%

Tubulointerstitial nephritis with uveitis: clinico-pathological and immunological study

et al. 2002

View full text Add to dashboard Cite

A 10-year-old boy was evaluated for fever, weight loss, uveitis, normocytic, normochromic anemia, renal insufficiency, and hypergammaglobulinemia of 8 weeks' duration. Infectious and neoplastic causes of fever were excluded. A renal biopsy performed in the 4th week of disease revealed diffuse plasmocytic interstitial nephritis. No treatment was prescribed and the patient was transferred to another hospital. Because clinical symptoms and renal insufficiency were still present, in the 8th week of disease a second biopsy was performed, which showed lympho-monocytic interstitial nephritis. At the same time, phenotypic analysis of peripheral blood mononuclear cells was carried out, revealing a significantly decreased number of CD3(+), CD4(+), and CD3(+)/CD8(+) cells, increased non-T CD3(-)/CD8(+) and CD56(+) NK cells, and decreased "naïve" (CD45RA(+)/CD4(+)) and memory (CD45RO(+)/CD8(+)) T lymphocytes. A 6-month course of oral prednisone was prescribed. Clinical symptoms and laboratory findings quickly returned to normal values. After 13 days of corticosteroid therapy, a second phenotypic analysis of peripheral blood mononuclear cells was performed, which revealed normalization of CD3(+), CD4(+), and CD3(+)/CD8(+) cells as well as proportions of non-T CD8(+) and CD56(+) NK lymphocytes, "naïve" and memory cells. This case shows spontaneous evolution of tubulointerstitial infiltrates from plasmacytic to lympho-monocytic, profound disturbances of the immunological system, and the beneficial effect of corticosteroids on both the clinical course and immunological disturbances.

show abstract

Section: Discussionmentioning

confidence: 99%

Tubulointerstitial nephritis with uveitis: clinico-pathological and immunological study

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Kidney involvement in mumps is almost always benign, but cases of severe interstitial nephritis have been reported. In such cases, renal biopsy or postmortem necropsy show evidence of immune complex deposition, interstitial mononuclear cell infiltration and fibrosis, oedema and focal tubular epithelial cell damage . Pancreatitis, diagnosed as severe epigastric pain and tenderness, has been reported in approximately 4% of cases .…”

Section: Clinical Features Pathogenesis and Pathologymentioning

confidence: 99%

Molecular biology, pathogenesis and pathology of mumps virus

Rubin

Eckhaus

Rennick

et al. 2014

The Journal of Pathology

189

139

View full text Add to dashboard Cite

Mumps is caused by the mumps virus (MuV), a member of the Paramyxoviridae family of enveloped, non-segmented, negative-sense RNA viruses. Mumps is characterized by painful inflammatory symptoms, such as parotitis and orchitis. The virus is highly neurotropic, with laboratory evidence of central nervous system (CNS) infection in approximately half of cases. Symptomatic CNS infection occurs less frequently; nonetheless, prior to the introduction of routine vaccination, MuV was a leading cause of aseptic meningitis and viral encephalitis in many developed countries. Despite being one of the oldest recognized diseases, with a worldwide distribution, surprisingly little attention has been given to its study. Cases of aseptic meningitis associated with some vaccine strains and a global resurgence of cases, including in highly vaccinated populations, has renewed interest in the virus, particularly in its pathogenesis and the need for development of clinically relevant models of disease. In this review we summarize the current state of knowledge on the virus, its pathogenesis and its clinical and pathological outcomes.

show abstract

“…Mumps virus may be isolated from urine during the first 5 days of the illness, at a time when urinalysis findings are abnormal. Plasma creatinine concentrations usually remain normal, despite the abnormal urine sediment, but more severe cases in unvaccinated children have resulted in fatal interstitial nephritis with interstitial mononuclear cell infiltration, edema, and focal tubular epithelial cell damage [180]. Renal biopsy specimens in adult mumps nephritis demonstrate an MPGN with deposition of IgA, IgM, C3, and mumps virus antigen in the glomeruli, which suggests an immune-complex-mediated process [181].…”

Section: Other Common Virus Infectionsmentioning

confidence: 99%