Mumps in the Eastern Bohemia Region of the Czech Republic - a Serological Survey 2008-2012

Fajfr, Miroslav; Štěpánová, Vlasta; Fajfrová, Jana

doi:10.21101/cejph.a4408

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…In the present study, it was observed that following SGIV infection, a significant accumulation of inflammatory cells occurred in the intestinal tissue of grouper, along with the up-regulation of the expression of pro-inflammatory cytokines including IL-1β, IL-6, IL-8, TNF-α, and NF-κB, indicating that SGIV invasion caused an intestinal inflammatory response. Studies related to rotavirus, reovirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), astrovirus, and other viruses have extensively reported cases of intestinal inflammation caused by viral infection [42]. NF-κB is hypothesized to serve as a significant transcription factor implicated in inflammatory diseases of the intestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates Singapore Grouper Iridovirus-Induced Intestine Injury in Orange-Spotted Grouper (Epinephelus coioides)

Wang

et al. 2023

Antioxidants

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Singapore grouper iridovirus (SGIV) is a new ranavirus species in the Iridoviridae family, whose high lethality and rapid spread have resulted in enormous economic losses for the aquaculture industry. Curcumin, a polyphenolic compound, has been proven to possess multiple biological activities, including antibacterial, antioxidant, and antiviral properties. This study was conducted to determine whether curcumin protected orange-spotted grouper (Epinephelus coioides) from SGIV-induced intestinal damage by affecting the inflammatory response, cell apoptosis, oxidative stress, and intestinal microbiota. Random distribution of healthy orange-spotted groupers (8.0 ± 1.0 cm and 9.0 ± 1.0 g) into six experimental groups (each group with 90 groupers): Control, DMSO, curcumin, SGIV, DMSO + SGIV, and curcumin + SGIV. The fish administered gavage received DMSO dilution solution or 640 mg/L curcumin every day for 15 days and then were injected intraperitoneally with SGIV 24 h after the last gavage. When more than half of the groupers in the SGIV group perished, samples from each group were collected for intestinal health evaluation. Our results showed that curcumin significantly alleviated intestine damage and repaired intestinal barrier dysfunction, which was identified by decreased intestine permeability and serum diamine oxidase (DAO) activity and increased expressions of tight junction proteins during SGIV infection. Moreover, curcumin treatment suppressed intestinal cells apoptosis and inflammatory response caused by SGIV and protected intestinal cells from oxidative injury by enhancing the activity of antioxidant enzymes, which was related to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling. Moreover, we found that curcumin treatment restored the disruption of the intestinal microbiota caused by SGIV infection. Our study provided a theoretical basis for the functional development of curcumin in aquaculture by highlighting the protective effect of curcumin against SGIV-induced intestinal injury.

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Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates Singapore Grouper Iridovirus-Induced Intestine Injury in Orange-Spotted Grouper (Epinephelus coioides)

Wang

et al. 2023

Antioxidants

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“…The subject requires further research. Czech studies show a poor response to mumps vaccination [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence of Vaccine-Preventable Childhood Diseases in the European Union and in the European Free Trade Association Countries

et al. 2021

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Introduction: Despite the widespread availability of vaccines, the incidence of vaccine-preventable childhood diseases (VPCD) started to grow in recent years. The aim of the study was to compare the annual incidence of selected VPCDs in the EU (European Union) and EFTA (European Free Trade Association) countries in the period of the last 5 years (2014–2019 or other intervals, depending on data availability), and the country-specific vaccine schedules. Methods: VPCD incidence rates in Europe were based on “The Surveillance Atlas of Infectious Diseases” by the ECDC (European Centre for Disease Prevention and Control); vaccination schedules were based on ECDC reports. Results: The obligation to vaccinate was not universal, and it generally only applied to two preparations: the MMR (measles, mumps, rubella) vaccine and the one against polio. During the study, the situation associated with mumps did not change or improve in individual countries; the median incidence amounted to 30 cases. The median incidence associated with rubella amounted to 1 case, but in a few countries, it grew very rapidly, i.e., in Germany, Italy, and Romania; in Poland, the incidence was clearly decreasing, from 5923 to 1532 cases. The most dynamic situation concerned measles. The total median was 2.4 cases per 100,000 population; the only one country with falling incidence was Germany. The diseases associated with Streptococcus pneumoniae and Neisseria meningitidis remained at a stable level in all analyzed countries. Conclusion: Vaccine schedules differ among the countries, so does the epidemiological situation of selected diseases. Morbidity on measles was the most disturbing phenomenon: the incidence rate increased in almost 40% of all countries, regardless of the obligation to vaccinate. The increasing incidence of VPCD may be due to anti-vaccine movements, the activity of which is often caused by mistrust and spreading misinformation. In order to better prevent the increase in morbidity, standardization of vaccine schedules and documentation should be considered in the EU countries.

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Paramyxoviruses: Mumps

Rubin¹,

Kennedy²

2022

Viral Infections of Humans

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Mumps in the Eastern Bohemia Region of the Czech Republic - a Serological Survey 2008-2012

Abstract: The data from our study, with a low number of positive samples in the first years of the study and an increase in the last two years, could suggest the occurrence of outbreaks every 4-6 years.

Cited by 4 publications

References 14 publications

Curcumin Alleviates Singapore Grouper Iridovirus-Induced Intestine Injury in Orange-Spotted Grouper (Epinephelus coioides)

Curcumin Alleviates Singapore Grouper Iridovirus-Induced Intestine Injury in Orange-Spotted Grouper (Epinephelus coioides)

Incidence of Vaccine-Preventable Childhood Diseases in the European Union and in the European Free Trade Association Countries

Paramyxoviruses: Mumps

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