Mumps disease in Beijing in the era of two-dose vaccination policy, 2005–2016

Ma, Rui; Lü, Li; Zhou, Tao; Pan, Jingbin; Chen, Meng; Pang, Xinghuo

doi:10.1016/j.vaccine.2018.03.074

Cited by 16 publications

(13 citation statements)

References 14 publications

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“…12 In our study, we found that a two-dose mumps vaccination conferred higher protection than onedose vaccination, similar to findings from previous studies. 16,22 Our results are also in agreement with a seroepidemiological survey on mump antibodies. 23 In China, despite implementation of large-scale immunization with onedose MMR in 2008, the incidence of mumps has not declined substantially since then.…”

Section: Discussionsupporting

confidence: 90%

“…However, the incidence of mumps and occurrence of outbreaks have declined in some more developed provinces in China where two-dose MMR vaccine has been introduced into EPI. 16,24 These results suggest that a two-dose MMR vaccination schedule through routine services is likely to be needed in order to contain the prevalence of mumps and reduce ongoing outbreaks in China. Changes in epidemic patterns of mumps after introduction of a two-dose vaccine schedule also need to be carefully considered in China.…”

Section: Discussionmentioning

confidence: 99%

“…10 After the policy for one-dose MMR vaccination targeting children aged 18-24 months was introduced in the Expanded Program on Immunization (EPI) in 2008, reports of mumps cases declined slightly, and the natural epidemic pattern of mumps has changed since that time. 10,16 However, mumps has continued to spread in vaccinated individuals over the last decade, and outbreaks occurring predominantly in schools 17,18 have prompted concerns about the effectiveness of the one-dose MMR vaccine immunization strategy currently used in China. The occurrence of continuous outbreaks highlights the need for introducing a two-dose immunization schedule in China.…”

Section: Introductionmentioning

confidence: 99%

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Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination

Qin

Wang²,

Yang³

et al. 2019

Human Vaccines & Immunotherapeutics

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In 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine (MuCV). A total of 97 cases were identified during the outbreak, and the overall attack rate was 8.2%. Among students with confirmed vaccination status, 90% had received at least one dose of MuCV. Cases were more likely than non-cases to report taking the school bus during the epidemic period (adjusted OR = 2.3, 95% CI: 1.4-3.7). Vaccine effectiveness (VE) was higher for two-dose MuCV (76%, 95% CI:49â€"89%) than for one-dose MuCV (59%, 95% CI: 36â€"74%. The protection afforded by both one-dose and two-dose MuCV waned over time, from 82% among students vaccinated within 5 years to 41% among those vaccinated more than 10 years previously for one-dose VE, and from 90% to 25% over the same time period for two-dose VE. We found that outbreaks of mumps can occur in schools despite high coverage of one-dose MuCV vaccination. Although the VE of both two-dose and one-dose MuCV wanes over time, the overall VE for two-dose MuCV was superior than that of one-dose MuCV. Therefore, a two-dose MuCV schedule through routine services is likely needed in order to control mumps epidemics in China.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination

Qin

Wang²,

Yang³

et al. 2019

Human Vaccines & Immunotherapeutics

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“…Our studies have shown that 8,525 mumps cases with an average annual incidence of 28.67 per 100,000 of the population were reported in Quzhou in 2005-2016. This was higher than that of Beijing and Jiangsu province [12,13]. The average mumps incidence from 2007-2010 modestly decreased compared to 2005-2006, due to the short timeframe of MMR vaccine introduction and the susceptible population with a low mumps vaccination coverage.…”

Section: Discussionmentioning

confidence: 77%

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Zhou

Song

ZhiYing³

et al. 2020

Journal of Immunology Research

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Background. From 2005 to 2016, the prevention and control of mumps in China have undergone three stages of transition. These include the use of MuCV as a self-supported vaccine, the introduction of one-dose MMR to the Expanded Program on Immunization (EPI), and the administration of two-dose MuCV following supplementary immunization activities (SIAs) using MM. Here, using surveillance data, we assessed the epidemiology of mumps during the three stages. Methods. Children in Quzhou of China born from 2005 to 2016 and registered in the Zhejiang Provincial Immunization Information System (ZJIIS) were included. We analyzed the epidemic data and calculated incidence and MuCV coverage via birth cohorts. Results. The average incidence of mumps in 2005-2006, 2007-2010, and 2011-2016 was 51.57, 41.02, and 12.53 per 100,000 individuals, respectively. The highest incidence was in children aged 6-14 years from 2005-2016, of which the majority were school students (67.84%). Approximately 90% of the reported outbreaks occurred in school children (primary school/middle school). The seasonal characteristics of mumps were less obvious from 2011 to 2016. The coverage of one-dose MMR in the 2005 birth cohort was 71.38%. For the 2006-2010 birth cohort, the coverage of one-dose MuCV was 96.82% and the coverage of two-dose MuCV was 17.68%. The children born from 2011 to 2016 were only free vaccinated with MMR; the coverage of one-dose MuCV was 99.10%. The mumps incidence in the three birth cohorts significantly declined (X2=805.90, P<0.001 for trend). Except the children less than two years old, the mumps incidence for the children born from 2006 to 2010 was higher than that for the children born from 2011 to 2016. Conclusion. The mumps incidence significantly declined following the introduction of one-dose MMR. The SIA using MM led to a rapid reduction of mumps cases. Therefore, we recommend a two-dose MuCV routine immunization schedule and improved vaccination coverage.

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“…However, from 2005 to 2010, the incidence of mumps has increased from 0.02% (20 in 100,000 individuals) to 0.03% (30 in 100,000 individuals) in China (Li et al 2017). Upward trend has been apperceived in several provinces and cities in China over the past decade, including Guangzhou, Jining, Fujian, and Beijing (Li et al 2016;Ma et al 2018;Hu et al 2018;Yang et al 2014a, b). Moreover, outbreaks mainly appear among vaccinated students (Qin et al 2019).…”

Section: Responsible Editor: Gerhard Lammelmentioning

confidence: 99%

Effects of extreme meteorological factors on daily mumps cases in Hefei, China, during 2011–2016

You

Jiang

et al. 2019

Environ Sci Pollut Res

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Mumps remains one of the worldwide major health problems over the past decade. Seasonal variations of mumps indicate that meteorological factors play an important role in the development of mumps, but few studies have investigated the relationship between extreme meteorological factors and the incidence of mumps. Daily mumps cases and meteorological factors in Hefei, China, from 2011 to 2016 were obtained. A generalized additive model combined with the distributed lag nonlinear model (DLNM) was used to quantify the risk of extreme meteorological factors on mumps incidence. Nonlinear relationships were observed among all meteorological factors and mumps incidence. We found that extremely low and high temperatures increased the risk of mumps. The relative risks (RRs) of the cumulative effects along 30 lag days were 2.02 (95%CI: 1.14-3.56) and 2.42 (95%CI: 1.37-4.24), respectively. Both short and long sunshine duration had negative correlation on mumps, with cumulative RRs of 0.64 (95%CI: 0.46-0.92) and 0.57 (95%CI: 0.44-0.74), respectively. In the subgroup analysis, males were found to be more sensitive to extreme weather, especially extreme temperatures and sunshine duration. This study suggests that extreme meteorological factors, especially extreme temperatures and sunshine duration, exert a significant impact on the incidence of mumps. When formulating and implementing effective strategies to the prevention and control of mumps, authorities should take the effect caused by extreme meteorological factors into consideration and pay more attention to susceptible populations, such as male children and teenagers.

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Mumps disease in Beijing in the era of two-dose vaccination policy, 2005–2016

Cited by 16 publications

References 14 publications

Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination

Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China

Effects of extreme meteorological factors on daily mumps cases in Hefei, China, during 2011–2016

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