Mumia flava gen. nov., sp. nov., an actinobacterium of the family Nocardioidaceae

Lee, Learn‐Han; Zainal, Nurullhudda; Azman, Adzzie Shazleen; Mutalib, Nurul Syakima Ab; Hong, Kui; Chan, Kok‐Gan

doi:10.1099/ijs.0.058701-0

Cited by 57 publications

(49 citation statements)

References 48 publications

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“…On the basis of phylogenetic, genotypic, and chemotaxonomic profiles, isolate MUSC 201 T is truly different from any existing genera in the family Nocardioidaceae ; hence, isolate MUSC 201 T represented a novel species in a new genus of the family Nocardioidaceae , for which the name “ Mumia flava gen. nov., sp. nov.” is proposed and published [55]. …”

Section: Resultsmentioning

confidence: 99%

Diversity and Antimicrobial Activities of Actinobacteria Isolated from Tropical Mangrove Sediments in Malaysia

Lee

Zainal

Azman

et al. 2014

The Scientific World Journal

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115

140

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The aim of this study was to isolate and identify Actinobacteria from Malaysia mangrove forest and screen them for production of antimicrobial secondary metabolites. Eighty-seven isolates were isolated from soil samples collected at 4 different sites. This is the first report to describe the isolation of Streptomyces, Mycobacterium, Leifsonia, Microbacterium, Sinomonas, Nocardia, Terrabacter, Streptacidiphilus, Micromonospora, Gordonia, and Nocardioides from mangrove in east coast of Malaysia. Of 87 isolates, at least 5 isolates are considered as putative novel taxa. Nine Streptomyces sp. isolates were producing potent antimicrobial secondary metabolites, indicating that Streptomyces isolates are providing high quality metabolites for drug discovery purposes. The discovery of a novel species, Streptomyces pluripotens sp. nov. MUSC 135T that produced potent secondary metabolites inhibiting the growth of MRSA, had provided promising metabolites for drug discovery research. The biosynthetic potential of 87 isolates was investigated by the detection of polyketide synthetase (PKS) and nonribosomal polyketide synthetase (NRPS) genes, the hallmarks of secondary metabolites production. Results showed that many isolates were positive for PKS-I (19.5%), PKS-II (42.5%), and NRPS (5.7%) genes, indicating that mangrove Actinobacteria have significant biosynthetic potential. Our results highlighted that mangrove environment represented a rich reservoir for isolation of Actinobacteria, which are potential sources for discovery of antimicrobial secondary metabolites.

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Section: Resultsmentioning

confidence: 99%

Diversity and Antimicrobial Activities of Actinobacteria Isolated from Tropical Mangrove Sediments in Malaysia

Lee

Zainal

Azman

et al. 2014

The Scientific World Journal

Self Cite

115

140

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“…This is a new genus in the family Nocardioidaceae, which was first approved in 2014 [47]. This strain was originally isolated from mangrove soil in Malaysia.…”

Section: Resultsmentioning

confidence: 99%

Burkholderia contaminansBiofilm Regulating Operon and Its Distribution in Bacterial Genomes

Voronina

Kunda

Ryzhova

et al. 2016

BioMed Research International

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Biofilm formation by Burkholderia spp. is a principal cause of lung chronic infections in cystic fibrosis patients. A “lacking biofilm production” (LBP) strain B. contaminans GIMC4587:Bct370-19 has been obtained by insertion modification of clinical strain with plasposon mutagenesis. It has an interrupted transcriptional response regulator (RR) gene. The focus of our investigation was a two-component signal transduction system determination, including this RR. B. contaminans clinical and LBP strains were analyzed by whole genome sequencing and bioinformatics resources. A four-component operon (BiofilmReg) has a key role in biofilm formation. The relative location (i.e., by being separated by another gene) of RR and histidine kinase genes is unique in BiofilmReg. Orthologs were found in other members of the Burkholderiales order. Phylogenetic analysis of strains containing BiofilmReg operons demonstrated evidence for earlier inheritance of a three-component operon. During further evolution one lineage acquired a fourth gene, whereas others lost the third component of the operon. Mutations in sensor domains have created biodiversity which is advantageous for adaptation to various ecological niches. Different species Burkholderia and Achromobacter strains all demonstrated similar BiofilmReg operon structure. Therefore, there may be an opportunity to develop a common drug which is effective for treating all these causative agents.

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“…Colonies appeared after 2 weeks incubation at 25∞C. The 16S rRNA gene sequence (803 bp) of the strain was analyzed using the EzTaxon-e database (http://eztaxon-e.ezbiocloud.net/) and showed 100% similarity with that of Mumia flava MUSC 201 T (KC907394) (Lee et al, 2014). It was suggested that the strain YSP-2-79 belongs to the genus Mumia.…”

Section: Taxonomy Of the Producing Strain Of Mumiamicin (1)mentioning

confidence: 99%

Mumiamicin: Structure and bioactivity of a new furan fatty acid from <i>Mumia</i> sp. YSP-2-79

Kimura

Tajima

Inahashi

et al. 2018

J. Gen. Appl. Microbiol.

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Mumia flava gen. nov., sp. nov., an actinobacterium of the family Nocardioidaceae

Cited by 57 publications

References 48 publications

Diversity and Antimicrobial Activities of Actinobacteria Isolated from Tropical Mangrove Sediments in Malaysia

Diversity and Antimicrobial Activities of Actinobacteria Isolated from Tropical Mangrove Sediments in Malaysia

Burkholderia contaminansBiofilm Regulating Operon and Its Distribution in Bacterial Genomes

Mumiamicin: Structure and bioactivity of a new furan fatty acid from <i>Mumia</i> sp. YSP-2-79

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