Multiwalled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles

Lin, Yi An; Cheetham, Andrew G.; Zhang, Pengcheng; Ou, Yu Chuan; Li, Yuguo; Liu, Guanshu; Hermida‐Merino, Daniel; Hamley, Ian W.; Cui, Honggang

doi:10.1021/nn505688b

Cited by 99 publications

(62 citation statements)

References 70 publications

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“…High hydrophilic content always tends to afford filamentous structures, while lower hydrophilic content prefers rod-like or spherical structures. 45, 56, 57 As a result, uniform nanorods were obtained at higher HCPT to Ce6 ratios through the confinement of the core HPCT nanostructure with an energy minimization process. It has been reported that cylindrical nanostructures exhibit very good pharmacokinetics and efficiency in drug delivery even better than spherical ones because of their multiple endocytotic mechanisms, enhanced internalization rates and effective adhesion to cell surface.…”

Section: Resultsmentioning

confidence: 99%

Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

et al. 2017

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Carrier-free nanodrugs formulated from supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. We report herein a new and simple method to directly assemble a small hydrophobic anticancer drug 10-Hydroxycamptothecin (HCPT) with a photosensitizer Chlorin e6 (Ce6) to form stable, discrete nanorods (NRs), which not only circumvent the extreme hydrophobicity of HCPT but also incorporate two different modalities into one delivery system for combination therapy. Different ratios of HCPT to Ce6 were evaluated to afford the optimal nanoformulation. The as-prepared HCPT/Ce6 NRs were fully characterized, indicating a relatively uniform size of about 360 nm in length and 135 nm in width, surface charge of about −33 mV. Efficient internalization of the NRs by cancer cells was observed by confocal microscope and the generation of singlet oxygen species arising from the NRs under 655 nm laser irradiation was detected by DCFH-DA. As a result, very potent in vitro efficacy against several kinds of cancer cell lines was achieved through chemo-photodynamic dual therapy. The in vivo tumor suppression effect of HCPT/Ce6 NRs was verified on a subcutaneous xenograft mouse model, achieving almost complete inhibition of the tumor growth, which may benefit from the superiority of nanomedicine and combination therapy. The rationale of this facile and green strategy for carrier-free nanodrug formulation via self-assembly approach might open up new opportunities for the development of combinatorial therapeutics for tumor.

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Section: Resultsmentioning

confidence: 99%

Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

et al. 2017

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“…195 By mixing of oppositely charged CPT drug amphiphiles (catanionic mixing), the Cui Lab reported on the formation of multiwalled nanotubes containing a fixed and high drug loading. 196 They found that the molecular mixing ratio, the solvent composition, the overall drug concentrations, as well as the molecular design are all important experimental parameters contributing to the tubular morphology.…”

Section: Small Molecule Sapdsmentioning

confidence: 99%

Self-assembling prodrugs

et al. 2017

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Covalent modification of therapeutic compounds is a clinically proven strategy to devise prodrugs with enhanced treatment efficacies. This prodrug strategy relies on modified drugs that possess advantageous pharmacokinetic properties and administration routes over their parent drug. Self-assembling prodrugs represent an emerging class of therapeutic agents capable of spontaneously associating into well-defined supramolecular nanostructures in aqueous solutions. The self-assembly of prodrugs expands the functional space of conventional prodrug design, providing a possible pathway to more effective therapies as the assembled nanostructure possesses distinct physicochemical properties that can be tailored to specific administration routes and disease treatment. In this review, we will discuss the various types of self-assembling prodrugs in development, providing an overview of the methods used to control their structure and function and, ultimately, our perspective on their current and future potential.

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“…It was postulated that the initial short filaments were the kinetic product of the hydrophobic collapse, with further rearrangement of the internal structure allowing the formation of β-sheet hydrogen bonds to give twisted two-filament fibrils as the thermodynamic product. A second approach was demonstrated by the catanionic mixing of oppositely charged derivatives of Cui’s four-CPT bearing drug amphiphile, qCPT-Sup35-K 2 and qCPT-Sup35-E 2 [110], which led to the formation of large, multi-walled nanotubes (Fig. 6C); very distinct structures from the smaller nanotubes formed by the individual components.…”

Section: Supramolecular Nanostructures Formed By Amphiphilic Prodrugsmentioning

confidence: 99%

“…(C) Cryogenic TEM image of a catanionic mixture of two oppositely charged drug amphiphiles, showing the formation of form large multiwalled nanotubes. Adapted from ref [110], copyright 2014 Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

Building nanostructures with drugs

2016

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The convergence of nanoscience and drug delivery has prompted the formation of the field of nanomedicine, one that exploits the novel physicochemical and biological properties of nanostructures for improved medical treatments and reduced side effects. Until recently, this nanostructure-mediated strategy considered the drug to be solely a biologically active compound to be delivered, and its potential as a molecular building unit remained largely unexplored. A growing trend within nanomedicine has been the use of drug molecules to build well-defined nanostructures of various sizes and shapes. This strategy allows for the creation of self-delivering supramolecular nanomedicines containing a high and fixed drug content. Through rational design of the number and type of the drug incorporated, the resulting nanostructures can be tailored to assume various morphologies (e.g. nanospheres, rods, nanofibers, or nanotubes) for a particular mode of administration such as systemic, topical, and local delivery. This review covers the recent advances in this rapidly developing field, with the aim of providing an in-depth evaluation of the exciting opportunities that this new field could create to improve the current clinical practice of nanomedicine.

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Multiwalled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles

Cited by 99 publications

References 70 publications

Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

Self-assembling prodrugs

Building nanostructures with drugs

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