Multivoxel Proton MR Spectroscopy in Malformations of Cortical Development

Leite, Cláudia C.; Lucato, Leandro Tavares; Sato, João Ricardo; Valente, Kette D.; Otaduy, Maria Concepción García

doi:10.3174/ajnr.a0511

Cited by 22 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most consistent findings are reductions in N-acetylaspartate (NAA) levels. These studies also found metabolic heterogeneities within visible lesions and disrupted metabolism in the perilesional and contralateral parenchyma, which appeared otherwise normal (Kuzniecky et al, 1997;Li et al, 1998;Mueller et al, 2005;Leite et al, 2007). Studies using MR perfusion imaging and positron emission tomography (PET) scans have also found disrupted metabolism and abnormal cerebral blood flow in certain MCD lesions (Lee et al, 1994;Widjaja et al, 2007).…”

mentioning

confidence: 86%

Phosphorus magnetic resonance spectroscopy in malformations of cortical development

Andrade

Otaduy

Valente³

et al. 2011

Epilepsia

View full text Add to dashboard Cite

SUMMARYPurpose: The aim of this study was to evaluate phospholipid metabolism in patients with malformations of cortical development (MCDs). Methods: Thirty-seven patients with MCDs and 31 control subjects were studied using three-dimensional phosphorus magnetic resonance spectroscopy ( 31 P-MRS) at 3.0 T. The voxels in the lesions and in the frontoparietal cortex of the control subjects were compared (the effective volumes were 12.5 cm 3 ). Robust quantification methods were applied to fit the time-domain data to the following resonances: phosphoethanolamine (PE); phosphocholine (PC); inorganic phosphate (Pi); glycerophosphoethanolamine (GPE); glycerophosphocholine (GPC); phosphocreatine (PCr); and a-, b-, and c-adenosine triphosphate (ATP). We also estimated the total ATP (ATP t = a-+b-+c-ATP), phosphodiesters (PDE = GPC+GPE), phosphomonoesters (PME = PE+PC), and the PME/PDE, PCr/ ATP t and PCr/Pi ratios. The magnesium (Mg 2+ ) levels and pH values were calculated based on PCr, Pi, and b-ATP chemical shifts. Key Findings: Compared to controls and assuming that a p-value < 0.05 indicates statistical significance, the patients with MCDs exhibited significantly lower pH values and higher Mg 2+ levels. In addition, the patients with MCDs had lower GPC and PDE and an increased PME/ PDE ratio. Significance: Mg 2+ and pH are important in the regulation of bioenergetics and are involved in many electrical activity pathways in the brain. Our data support the idea that neurometabolic impairments occur during seizure onset and propagation. The GPC, PDE, and PME/PDE abnormalities also demonstrate that there are membrane turnover disturbances in patients with MCDs.

show abstract

mentioning

confidence: 86%

Phosphorus magnetic resonance spectroscopy in malformations of cortical development

Andrade

Otaduy

Valente³

et al. 2011

Epilepsia

View full text Add to dashboard Cite

show abstract

“…Leite and colleagues, in a study of multivoxel proton magnetic resonance spectroscopy (MRS) showed reduced levels of N-acetylaspartate/creatine (NAA/Cr) in both the MCD and on the normal appearing contralateral side in patients with unilateral lesions, warning the fact that the metabolic abnormalities in MCD extend far beyond focal lesions evident on structural tests 28,29 . Others authors have also demonstrated metabolic abnormalities in MCD, such as reduced NAA and increased choline (Cho), as well as in the macroscopically normal perilesional zone, usually decreased NAA and Cr [30][31][32] .…”

Section: Modern Neuroimaging Techniquesmentioning

confidence: 99%

Malformations of cortical development: current concepts and advanced neuroimaging review

Andrade

Leite

2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Malformations of cortical development (MCD) result from disruptions in the complex process of the human brain cortex formation and are highly associated to severe epilepsy, neurodevelopmental delay and motor dysfunction. Nowadays, magnetic resonance imaging (MRI) is the cornerstone of the work-up of patients with epilepsy and modern advanced imaging techniques have improved not only our ability to detect and characterize cortical malformations, but also in identifying associated functional abnormalities that are far beyond the structural visualized lesions. Herein, we address the most currently used classifications of MCD and make a concise review of the embryological process of cortical development. Our main goal is to summarize recent advances and new trends in diagnostic imaging techniques concerning MCD. Thereafter, follows a brief discussion of specific disorders and their radiological features. Key words: malformations of cortical development, epilepsy, magnetic resonance imaging, diagnostic imaging.Malformações do desenvolvimento cortical: conceitos atuais e revisão de neuro imagem avançada RESUMO As malformações do desenvolvimento cortical (MDC) resultam de distúrbios no complexo processo do desenvolvimento do córtex cerebral humano e estão comumente associadas a epilepsia severa e disfunções neuropsicomotoras. Atualmente, as imagens por ressonância magnética (RM) são a pedra angular no manejo de pacientes com epilepsia e modernas técnicas avançadas de imagem melhoraram não só a nossa capacidade de detectar e caracterizar as malformações corticais, mas também levaram ao reconhecimento de anomalias funcionais associadas que estão muito além das lesões estruturais visibilizadas. Abordaremos as classificações mais utilizadas de MDC e revisaremos a embriologia do desenvolvimento cortical. Nosso principal objetivo é destacar os avanços recentes e as novas tendências em técnicas de diagnóstico por imagens relacionadas às MDC. Em seguida, faremos uma breve discussão sobre alguns transtornos específicos e suas características radiológicas. Palavras-chave: malformações do desenvolvimento cortical, epilepsia, imagem por ressonância magnética, diagnóstico por imagem.

show abstract

“…MRI allowed increased recognition and more accurate diagnosis (14,15). In our study, Assessment of the diagnostic reliability of brain CT and MRI 9 2 cases of FCD were diagnosed by MRI while they were not evident on CT, one case of subcortical nodular heterotopia was diagnosed by MRI while it was not evident on CT. FCD is one of the most common forms of focal developmental disorders constituting approximately 25% of patients (13,16).…”

Section: Discussionmentioning

confidence: 94%

Assessment of the diagnostic reliability of brain CT and MRI in pediatric epilepsy patients

Alam-Eldeen

Hasan

2015

The Egyptian Journal of Radiology and Nuclear Medicine

View full text Add to dashboard Cite

Objective: Analysis of the role of CT and MRI in evaluation of pediatric epilepsy and their diagnostic utility to detect various pathologic entities at one center. Patients and methods: From April 2012 to April 2014, 181 children with epilepsy were underwent standardized CT and or MRI in the Department of Diagnostic Radiology at Sohag University Hospitals. We retrospectively analyzed whether lesions were detected and whether were precisely characterized by CT and or MRI. Results: Of the 181 patients included in the study, abnormalities were detected in 132 patients (73%) while normal brain images were found in 49 patients (27%). Of the 74 patients had CT only, abnormalities were detected in 73% while 27% were normal. Of the 89 patients underwent MRI only, abnormalities were detected in 74% while 26% were normal. Of the 18 patients underwent CT and MRI, abnormalities were detected in 67% while 33% were normal. Conclusion: Seizure disorders are among the most frequent neurologic problems that occur in childhood. MRI is the technique of choice and is superior to CT in identifying underlying cause. However, CT can serve as a screening modality and MRI would be performed to define abnormalities found on CT or in negative CT studies.

show abstract

Multivoxel Proton MR Spectroscopy in Malformations of Cortical Development

Cited by 22 publications

References 37 publications

Phosphorus magnetic resonance spectroscopy in malformations of cortical development

Phosphorus magnetic resonance spectroscopy in malformations of cortical development

Malformations of cortical development: current concepts and advanced neuroimaging review

Assessment of the diagnostic reliability of brain CT and MRI in pediatric epilepsy patients

Contact Info

Product

Resources

About