Multivitamin/Multimineral Supplement Use is Associated with Increased Micronutrient Intakes and Biomarkers and Decreased Prevalence of Inadequacies and Deficiencies in Middle-Aged and Older Adults in the United States

Wallace, Taylor C.; Frankenfeld, Cara L.; Frei, Balz; Shah, Alpa; Yu, Ching-Ray; Klinken, B. Jan-Willem van; Adeleke, Maryann

doi:10.1080/21551197.2019.1656135

Cited by 18 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, at the end of our 16 wk intervention, the status of only three of the four measured vitamins in the MVMS (B12, C and folate) were significantly increased and no changes in mineral status were observed. These results agree with those obtained by Wallace et al (Wallace et al 2019) from the NHANES showing greater intake of vitamins B1, B12, C and folate and the minerals calcium, copper, magnesium, zinc among MVMS users than nonusers but only the status of vitamins B1, B12 and folate were significantly greater in the users. The impact of MVMS may vary with the population studied; e.g.…”

Section: Mvms (N ¼ 35)supporting

confidence: 91%

“…A 12-wk randomized, placebo-controlled trial of a MVMS reported increases in the status of vitamin C and zinc but not vitamin D in healthy older adults (Fantacone et al 2020). The absence of change in the status of many of the nutrients formulated in an MVMS may be due to a variety of factors, including the nutrient dose, study duration, bioavailability, shallow doseresponse curve with adequacy or saturation at baseline, and, for minerals, limitations associated with plasma concentrations as a biomarker of whole body status (Wallace et al 2019).…”

Section: Mvms (N ¼ 35)mentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Multi-Vitamin/Multi-Mineral Supplementation on Nutritional Status in Older Adults Receiving Drug Therapies: A Double-Blind, Placebo-Controlled Trial

Chen

Rogers

McKay

et al. 2020

Journal of Dietary Supplements

View full text Add to dashboard Cite

Polypharmacy regimens may increase the susceptibility of older adults to micronutrient inadequacy and deficiency via impairment of nutritional status. We hypothesized that a multi-vitamin-mineral supplement (MVMS) could improve nutritional status in older adults prescribed diuretics, metformin, and/or proton pump inhibitors (PPIs). We conducted a randomized, double-blind, placebo controlled, parallel clinical trial in which eligible subjects were instructed to consume either a MVMS or placebo for 16 wk. Fasting blood was collected at baseline, 8, and 16 wk and the status of selected vitamins and minerals determined. Thirty-five and 19 men and women aged 45-75 yrs in the in MVMS and placebo arms, respectively, completed the trial. The mean total number of medications among the three drug classes taken by participants did not differ between two groups. The status of vitamins B1, B12, C and folate and calcium, copper, magnesium and zinc at baseline were within normal ranges. The MVMS group had a greater change in nutrient status after 16 wk compared to the placebo group for serum folate (7.5 vs.-1.6 ng/mL, p < 0.0001), vitamin B12 (159.2 vs.-33.9 pg/mL, p ¼ 0.007), and plasma vitamin C (0.2 vs. 0.0 mg/dL, p ¼ 0.004). Other measured vitamins and minerals were not significantly changed during the intervention. In conclusion, the status of vitamins B12, C and folate improved with MVMS but remained within normal ranges in older adults taking diuretics, metformin, and/or PPIs.

show abstract

Section: Mvms (N ¼ 35)supporting

confidence: 91%

Section: Mvms (N ¼ 35)mentioning

confidence: 99%

The Effect of Multi-Vitamin/Multi-Mineral Supplementation on Nutritional Status in Older Adults Receiving Drug Therapies: A Double-Blind, Placebo-Controlled Trial

Chen

Rogers

McKay

et al. 2020

Journal of Dietary Supplements

View full text Add to dashboard Cite

show abstract

“…Among the risk factors for the subclinical deficiencies were advanced age, frailty, lack of physical activity and no or irregular use of dietary supplements. Dietary supplement intake is an easily modifiable risk factor, and recent studies have confirmed that regular use of dietary supplements is associated with lower rates of subclinical deficiencies of nearly every micronutrient investigated in the study [ 72 ]. Age-specific requirements are not really clear, but higher intakes have been recommended due to the frequently impaired intestinal absorption or distribution [ 73 ].…”

Section: Malnutrition: Definition and Types And How To Screen For Themmentioning

confidence: 99%

Malnutrition in Older Adults—Recent Advances and Remaining Challenges

2021

View full text Add to dashboard Cite

Malnutrition in older adults has been recognised as a challenging health concern associated with not only increased mortality and morbidity, but also with physical decline, which has wide ranging acute implications for activities of daily living and quality of life in general. Malnutrition is common and may also contribute to the development of the geriatric syndromes in older adults. Malnutrition in the old is reflected by either involuntary weight loss or low body mass index, but hidden deficiencies such as micronutrient deficiencies are more difficult to assess and therefore frequently overlooked in the community-dwelling old. In developed countries, the most cited cause of malnutrition is disease, as both acute and chronic disorders have the potential to result in or aggravate malnutrition. Therefore, as higher age is one risk factor for developing disease, older adults have the highest risk of being at nutritional risk or becoming malnourished. However, the aetiology of malnutrition is complex and multifactorial, and the development of malnutrition in the old is most likely also facilitated by ageing processes. This comprehensive narrative review summarizes current evidence on the prevalence and determinants of malnutrition in old adults spanning from age-related changes to disease-associated risk factors, and outlines remaining challenges in the understanding, identification as well as treatment of malnutrition, which in some cases may include targeted supplementation of macro- and/or micronutrients, when diet alone is not sufficient to meet age-specific requirements.

show abstract

“…Все исследования эффективности приема ВМК можно разделить на два направления: оценку влияния на витаминно-минеральный статус организма (Wallace et al, 2019) и на функции организма, включая снижение риска заболеваний.…”

Section: мультимикронутриентныеunclassified

Untitled

2020

TEM

View full text Add to dashboard Cite

Multivitamin/Multimineral Supplement Use is Associated with Increased Micronutrient Intakes and Biomarkers and Decreased Prevalence of Inadequacies and Deficiencies in Middle-Aged and Older Adults in the United States

Cited by 18 publications

References 30 publications

The Effect of Multi-Vitamin/Multi-Mineral Supplementation on Nutritional Status in Older Adults Receiving Drug Therapies: A Double-Blind, Placebo-Controlled Trial

The Effect of Multi-Vitamin/Multi-Mineral Supplementation on Nutritional Status in Older Adults Receiving Drug Therapies: A Double-Blind, Placebo-Controlled Trial

Malnutrition in Older Adults—Recent Advances and Remaining Challenges

Untitled

Contact Info

Product

Resources

About