Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data

Che, Bizhong; Zhong, Chongke; Zhang, Ruijie; Wang, Meng; Zhang, Yonghong; Han, Liyuan

doi:10.1007/s00394-022-02865-4

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Yeung et al found multivitamins improve memory recall [ 11 ] and Song et al found those who take calcium or vitamin C supplements showed a lower risk of diabetes [ 12 ]. A large prospective study found multivitamin supplementation associated with a modest reduction in CVD [ 13 ] and in a recent examination of over 489,000 individuals from the NIH-American Association of Retired Persons (AARP), Lim and colleagues [ 14 ] found multivitamins to be cancer-preventive for colon cancer in both men and women, although they found no evidence of a protective role for other site-specific cancers. Gaziano and colleagues [ 15 ] also found that a daily multivitamin did not reduce site-specific cancers but was associated with reduced incidence of all cancers (excluding non-melanoma skin cancer).…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D in Cardiovascular Diseases

et al. 2023

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Cardiovascular diseases (CVD) are the leading cause of death in the United States. The previous literature demonstrates the importance of vitamin D for overall health, and a significant body of literature has examined the benefits of optimal serum 25-hydroxyvitamin D [25(OH)D] on cardiovascular health, but the results remain inconclusive. The objective of this study was to determine the association between reported CVD and [25(OH)D]. We utilized the 2015–2018 National Health and Nutrition Examination Survey and included adults aged 20 years and older (n = 9825). CVD was defined as having a stroke, heart attack, heart failure, or coronary heart disease. Vitamin D status was categorized as a serum 25(OH)D deficiency at <30 nmol/L; insufficiency at 30 to 49.9 nmol/L; normal/optimal at 50 to 125 nmol/L; and adequacy at >125 nmol/L. Statistical analysis was performed using Chi-square tests, t-tests were conducted to investigate the differences in participant characteristics among those with CVD and without CVD, and regression models were used to explore the association between vitamin D levels and CVD status. We found 25(OH)D deficiency associated with CVD (Adjusted Odds Ratio (AOR) = 1.48; 95% CI = 1.11–1.98; p < 0.05). [25(OH)D] insufficiency was also associated with CVD (AOR = 1.28; 95% CI = 1.06–1.54; p < 0.05). The 25(OH)D adequacy was not associated with reported CVD. For the prevention of CVD, healthcare professionals may recommend the use of vitamin D supplementation to improve cardiovascular health in adults while considering individual needs.

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Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D in Cardiovascular Diseases

et al. 2023

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Association between use of vitamin and mineral supplement and non-alcoholic fatty liver disease in hypertensive adults

Park,

Smith-Warner,

Zhang

et al. 2023

Sci Rep

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Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic metabolic disorder in hypertensive adults. Impaired metabolism of micronutrients may increase NAFLD risk by exacerbating oxidative stress, insulin resistance, and inflammation among hypertensive adults. In this first cross-sectional analysis of 7,376 hypertensive adults with 2,015 NAFLD cases in the Korea National Health and Nutrition Examination Survey, vitamin and mineral supplements (VMS) use was identified via questionnaire. NAFLD was defined by a hepatic steatosis index > 36. Multivariable-adjusted odds ratios (MVOR) and 95% confidence intervals (CIs) were calculated using logistic regression models. In our study, 18.6% were current users of VMS; of these, 76.7% used multi-vitamin/mineral supplements. Current VMS users had significantly lower odds of NAFLD, compared with non-users (MVOR [95% CI]: 0.73 [0.58–0.92]). The inverse association became attenuated and non-significant among those consuming VMS at higher frequency (≥ 2 times/day), for longer duration (> 16 months), and taking ≥ 2 VMS products. The inverse association with current use of VMS was only evident in those aged < 56 years (MVOR [95% CI]: 0.54 [0.40–0.72]) and men (MVOR [95% CI]: 0.56 [0.40–0.80])(Pinteraction ≤ 0.04). Our results suggest that VMS use may lower NAFLD risk, particularly among younger or male hypertensive adults, if taken in moderation.

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The Study of Correlation between Serum Vitamin D Levels and Cardiovascular Disease: Based on Data from NHANES in the United States from 2011~2020

汪

2024

ACM

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Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data

Cited by 4 publications

References 31 publications

The Role of Vitamin D in Cardiovascular Diseases

The Role of Vitamin D in Cardiovascular Diseases

Association between use of vitamin and mineral supplement and non-alcoholic fatty liver disease in hypertensive adults

The Study of Correlation between Serum Vitamin D Levels and Cardiovascular Disease: Based on Data from NHANES in the United States from 2011~2020

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