Multivitamin and mineral supplementation modulates oxidative stress and antioxidant vitamin levels in serum and follicular fluid of women undergoing in vitro fertilization

Özkaya, Mehmet Okan; Nazıroğlu, Mustafa

doi:10.1016/j.fertnstert.2010.01.066

Cited by 71 publications

(46 citation statements)

References 7 publications

(10 reference statements)

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“…They suggested that these molecules may be effective in quenching excessive generation of free radicals, but they do not seem to play a contributory role in achieving successful pregnancy following IVF. This is an important observation in view of the fact that several groups have the opinion that antioxidants, mineral and vitamin supplementation may considerably improve the IVF success rate [42,43]. However, our study conflicts with the results of some other studies [8,36,44], which observed that lower levels of antioxidants predict decreased fertilization potential.…”

Section: Discussioncontrasting

confidence: 96%

Determination of oxidative stress balance in follicular fluid

Fabjan

Vrtačnik-Bokal

Kumer

et al. 2018

LaboratoriumsMedizin

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Background: The role of oxidative stress in female reproduction is an area that needs more investigation. This study aims to assess the oxidative stress levels in follicular fluid (FF) samples of women undergoing in vitro fertilization (IVF) and to relate them to different diagnoses. Methods: A total of 199 woman were enrolled; 37 of them were diagnosed with polycystic ovary syndrome (PCOS), 71 with endometriosis and 41 with tubal factor infertility (TFI) and 50 of the patients were used as a control group. A sample of FF was collected from each patient at an oocyte retrieval day and analyzed for oxidative stress by measuring a class of reactive oxygen metabolites (ROMs) (dROMs test) and also analyzed for the plasma antioxidant test (PAT). Results: The data analyzed in FF were related to different diagnoses. Groups were not significantly different in age and body mass index (BMI), except for the PCOS group. There was a significant difference between dROMs and PAT levels in FF of patients vs. control group. The same finding was seen when the dROM/PAT ratio was used. Conclusions: We conclude that the evaluation of oxidative stress in FF needs more investigation with regard to markers in the follicular microenvironment.

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Section: Discussioncontrasting

confidence: 96%

Determination of oxidative stress balance in follicular fluid

Fabjan

Vrtačnik-Bokal

Kumer

et al. 2018

LaboratoriumsMedizin

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“…The significant pregnancy outcome relative to control in the current study is similar to the one obtained by Howard et al even though theirs was on unexplained infertility but differ from other randomised control trials which did not show significant difference in pregnancy rates. 28,[29][30][31] Most of the earlier studies used either minerals or vitamins as their supplement but in the current study a combination of minerals, vitamins and other antioxidants were used which may be responsible for the difference in outcome even though the index study was on PCOS patients. The antioxidant vitamins such as vitamins A, C, E and minerals such as zinc and copper are important in restoring and maintaining the oxidant and antioxidant balance in blood and tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The antioxidant vitamins such as vitamins A, C, E and minerals such as zinc and copper are important in restoring and maintaining the oxidant and antioxidant balance in blood and tissue. 31 the multivitamins and minerals ameliorates the oxidant changes probably through its free radical scavenging in the blood, serum and follicular fluids.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

Panti

Shehu

Saidu

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

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“…This acts as a compensatory mechanism that prevents damage induced by ROS, which attack nucleic acids, proteins, and membrane phospholipids [42][43] . The antioxidant defense system of organisms is composed of antioxidant enzymes such as catalase, glutathione peroxidase, superoxide dismutase, and non enzymatic molecules such as vitamins A and E [44] . For example, O 2 − , the parental form of intracellular reactive oxygen species, is a highly reactive molecule but can be converted to H 2 O 2 by superoxide dismutase and then to oxygen and water by several enzymes including catalase, glutathione peroxidase, and lipid peroxiredoxin [42,45] .…”

Section: Resultsmentioning

confidence: 99%

Biochemical Markers of Oxidative Stress in Brain of Zebrafish Danio rerio Exposed to Different Heavy Metals Lead and Cobalt

Singh¹,

Ansari²

2017

IJLSSR

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ABSTRACT-Aquatic organisms have been considered to concentrate metals several times greater than environmental levels. Fishes have been used for many decades to evaluate the pollution status of water and thus considered as excellent biological indicator of heavy metals in aquatic environments. Heavy metals are natural tress components of the aquatic environment, but their levels have increased due to domestic, industrial, mining and agricultural activities. These heavy metals when accumulated in the fish tissues, they damage and weaken the mechanisms concerned leading to physiological, pathological and biochemical changes. The lead is non essential element while cobalt is an essential element for living organisms but its presence in fresh water in higher concentration are toxic to organism's brain, liver, ovary, kidney and gills of the fish. The present study was aimed to investigate the changes due to two heavy metals (lead & cobalt) on the activity of the antioxidant enzyme, Catalase (CAT), Reduced glutathione (GSH), and Lipid peroxidation (LPO) in the brain of Danio rerio during 5, 10, 15 and 20 days of exposure period. For this study adult fishes were exposed to four different concentrations viz., 20, 30, 40 and 50 mg/l of cobalt and 5, 9, 13, and 17 mg/l of lead.

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Multivitamin and mineral supplementation modulates oxidative stress and antioxidant vitamin levels in serum and follicular fluid of women undergoing in vitro fertilization

Cited by 71 publications

References 7 publications

Determination of oxidative stress balance in follicular fluid

Determination of oxidative stress balance in follicular fluid

Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

Biochemical Markers of Oxidative Stress in Brain of Zebrafish Danio rerio Exposed to Different Heavy Metals Lead and Cobalt

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