2004
DOI: 10.1091/mbc.e04-08-0666
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Multivesicular Body-ESCRT Components Function in pH Response Regulation inSaccharomyces cerevisiaeandCandida albicans

Abstract: The ESCRT-I, -II, and -III protein complexes function to create multivesicular bodies (MVBs) for sorting of proteins destined for the lysosome or vacuole. Prior studies with Saccharomyces cerevisiae have shown that the ESCRT-III protein Snf7p interacts with the MVB pathway protein Bro1p as well as its homolog Rim20p. Rim20p has no role in MVB formation, but functions in the Rim101p pH-response pathway; Rim20p interacts with transcription factor Rim101p and is required for the activation of Rim101p by C-termina… Show more

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Cited by 156 publications
(238 citation statements)
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References 54 publications
(104 reference statements)
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“…Largely consistent results have been obtained independently for S. cerevisiae (Barwell et al, 2005;Hayashi et al, 2005;Rothfels et al, 2005) and other fungi (Kullas et al, 2004;Xu et al, 2004;Cornet et al, 2005). These findings led to the proposal that vesicle-associated Snf7 is required for productive interaction with Rim20, leading to Rim101 cleavage (Xu et al, 2004).…”
supporting
confidence: 72%
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“…Largely consistent results have been obtained independently for S. cerevisiae (Barwell et al, 2005;Hayashi et al, 2005;Rothfels et al, 2005) and other fungi (Kullas et al, 2004;Xu et al, 2004;Cornet et al, 2005). These findings led to the proposal that vesicle-associated Snf7 is required for productive interaction with Rim20, leading to Rim101 cleavage (Xu et al, 2004).…”
supporting
confidence: 72%
“…Functional significance of the interaction was underscored by the observation that mutants defective in any of eight ESCRT-I, -II, and -III subunits failed to produce cleaved Rim101 (Xu et al, 2004). On the other hand, mutants defective in Vps4 or in Vps2 and Vps24, the ESCRT-III subunits that recruit Vps4, were capable of producing cleaved Rim101 (Xu et al, 2004). Largely consistent results have been obtained independently for S. cerevisiae (Barwell et al, 2005;Hayashi et al, 2005;Rothfels et al, 2005) and other fungi (Kullas et al, 2004;Xu et al, 2004;Cornet et al, 2005).…”
mentioning
confidence: 59%
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