Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Silva, A.F.; Sarraguça, Mafalda C.; Fonteyne, Margot; Vercruysse, Jurgen; Leersnyder, Fien De; Vanhoorne, Valérie; Bostijn, N.; Verstraeten, Maxim; Vervaet, Chris; Remon, Jean Paul; Beer, Thomas De; Lopes, João A.

doi:10.1016/j.ijpharm.2017.05.075

Cited by 34 publications

(12 citation statements)

References 36 publications

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“…Looking beyond the scope of this paper, a relatively straightforward early warning scheme for deviations can subsequently be implemented through applying statistical process control the form of which is discussed by Silva et al [30]. It is also demonstrated that if the need is to implement a control system to compensate for disturbances, a quantitative calibration model can be constructed for closed loop control or use in a feedforward scheme.…”

Section: Discussionmentioning

confidence: 98%

Opportunities for Process Control and Quality Assurance Using Online NIR Analysis to a Continuous Wet Granulation Tableting Line

et al. 2018

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This paper investigates the application of on-line near infra-red measurements as a means to measure blend uniformity in a continuous tableting line. Underlying all the monitoring and control methods is the ability to measure key tablet properties on-line at a rate suitable for control purposes. The use of NIR to determine any deviations in blend uniformity is demonstrated by interpreting the relevant spectral signature allowing quantitative information to be acquired for process monitoring and quality assurance. In addition to demonstrating the functionality of the NIR probe, the practical issues arising in the application are discussed. The composition of the blend was measured using an NIR probe over a range of concentrations and the results were calculated comparing sub unit dose scale of scrutiny of small populations. This was compared with predicted product quality for whole tablets over the whole production period. This technique has demonstrated how data collected online can be used to successfully predict the quality of the whole production run for the purposes of real time product quality assurance.

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Section: Discussionmentioning

confidence: 98%

Opportunities for Process Control and Quality Assurance Using Online NIR Analysis to a Continuous Wet Granulation Tableting Line

et al. 2018

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“…Silva et al [79] have developed a multivariate SPC strategy for a continuous tablet manufacturing line comprising a TSG. The monitoring and quality control system was able to detect the disturbances imposed, for example, in granulator barrel temperature, liquid mass flow, powder mass flow, and screw speed.…”

Section: The Interaction Table For the Hp-tsg Is Presented Inmentioning

confidence: 99%

“…However, [79] also observed that the process may return to a different steady state after perturbations, indicating irreversible process behavior and possibly requiring extra care in control design.…”

Section: The Interaction Table For the Hp-tsg Is Presented Inmentioning

confidence: 99%

Process control in intensified continuous solids handling

Ohenoja

Boodhoo

Reay

et al. 2018

Chemical Engineering and Processing - Process Intensification

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“…Urbanization and rapid Industrialization generate enormous amounts of hazardous wastes and pharmaceutical containing waste water is one among them [1]. Pharmaceutical effluents are complex in nature and hazardous to the ecosystem.…”

Section: Introductionmentioning

confidence: 99%

Optimization and extraction of pharmaceutical micro-pollutant - norfloxacin using emulsion liquid membranes

Muthusaravanan¹,

Priyadharshini²,

Sivarajasekar³

et al. 2019

DWT

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Amongst the present water treatment technologies membrane separation is gaining focus nowadays. Emulsion liquid membrane is one of the advanced strategies used for pollution removal from waste water in which the use of biosurfactant makes this approach eco-friendly technique. The norfloxacin belongs to the fluoroquinolones class of antibiotic and extensively used for urinary tract infections, which is the model pollutant in this study. Saponin was solvent extracted from soapnuts and used as biosurfactant. The main and interactive effects of parameters such as saponin concentration (0.01-0.03 g/100 mL), NaOH concentration (0.25-0.75 M) and Initial Norfloxacin concentration (25-75 mg/L) were investigated using Response Surface Methodology (RSM)-Box Behnken Design (BBD) and Artificial Neural Networks (ANN) design. The results suggested that developed 3-8-1 ANN model evaluated in terms of performance measure (R 2 : 0.9806, Chi square: 0.02) and error functions (RMSE: 0.11, MAE: 0.09, SEP: 1.16, MPE: 1.76) demonstrated superiority more precisely than the RSM model in terms of both data fitting and prediction capability. The optimal conditions for ELM were found to be: initial norfloxacin concentration 67.65 mg/L, saponin concentration 0.021 mg/100 mL, and NaOH concentration 0.36 M and the extraction efficiency at these parameter settings would be 91.27%.

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Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Cited by 34 publications

References 36 publications

Opportunities for Process Control and Quality Assurance Using Online NIR Analysis to a Continuous Wet Granulation Tableting Line

Opportunities for Process Control and Quality Assurance Using Online NIR Analysis to a Continuous Wet Granulation Tableting Line

Process control in intensified continuous solids handling

Optimization and extraction of pharmaceutical micro-pollutant - norfloxacin using emulsion liquid membranes

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