Multivariate Optimization of Separation Conditions for Simultaneous Determination of Acemetacin and Chlorzoxazone in a Pharmaceutical Preparation by HPLC Using Response Surface Methodology

Aybaba, Cigdem; Palabıyık, İsmail Murat; Çağlayan, Mehmet Gökhan; Onur, Feyyaz

doi:10.5740/jaoacint.11-092

Cited by 3 publications

(2 citation statements)

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“…It is used as an adjunct in the symptomatic treatment of painful muscle spasm. 1,2 phy, [3][4][5][6][7][8][9][10][11][12][13] thin layer chromatography, [14][15][16][17] liquid chromatography-tandem mass spectrometry, 18 packed column supercritical fluid chromatography, [19][20] gas chromatography, [21][22][23] spectrophotometry, [24][25][26][27][28][29][30][31][32][33][34][35] fluorimetry, 36 and capillary zone electrophoresis. 37 Two papers have been described in literature concerning the voltammetric determination of chlorzoxazone based on the oxidation of the drug at the glassy carbon electrode and gold electrode.…”

Section: Introductionmentioning

confidence: 99%

Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode

Zayed

Issa

2020

ACSi

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The electrochemical behavior of chlorzoxazone at the carbon paste electrode was investigated in 0.04 mol/L Britton-Robinson buffer pH 6.50 using cyclic and differential pulse voltammetric techniques. Cyclic voltammetric studies indicated that the oxidation of the drug was irreversible and controlled mainly by diffusion. Experimental and instrumental parameters were optimized (50 mV/s scan rate, 50 mV pulse amplitude, and 0.04 mol/L Britton-Robinson (BR) buffer pH 6.50 as a supporting electrolyte) and a sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.17–1.68 μg/mL chlorzoxazone, with detection and quantitation limits of 0.05 and 0.16 μg/mL, respectively. The proposed voltammetric method was successfully applied to the determinationof the drug in its pharmaceutical formulation (Myoflex tablets), and in spiked human urine samples.

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Section: Introductionmentioning

confidence: 99%

Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode

Zayed

Issa

2020

ACSi

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“…The analytically-oriented reports on the acemetacin are related to the use of separation methods mainly. Most of them are related to different versions of chromatography [6][7][8] along with the combination with the most popular detection mode in mass spectrometry, but the literature survey reports also on the use of electrophoresis 9,10 or less obvious spectrophotometry. 11,12 In electrochemical studies [13][14][15] among others one can find two recent, parallelly presented voltammetric methods on the determination of ACM with diverse strategies.…”

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confidence: 99%

Tailoring Electrochemical Activity of Acemetacin with Electrocatalytic Properties of Graphene Derivatives

Ivanovski¹,

Festinger²,

Karpowicz³

et al. 2023

J. Electrochem. Soc.

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Differential pulse and cyclic voltammetry were used to investigate the electrocatalytic effects of two oxygen-containing graphene derivatives, as surface modifiers, on the oxidation mechanism of acemetacin (ACM), a non-steroidal anti-inflammatory drug. Scanning electron microscopy was employed to examine the modified electrodes surfaces, showing that the morphology and composition of the coatings strongly influenced the electroanalysis of ACM. Cyclic voltammetry was used to confirm ACM adsorption dependence on the type and structure of the modifier. Density functional theory calculations were performed to analyse the electron density and spatial distribution of the HOMO orbital in order to determine the most probable oxidation site in the molecule. It was found that the composition and structure of the modifiers influenced the surface properties of the working electrodes and thus strongly affected ACM adsorption. Finally, it was observed that different oxidation mechanisms were preferred at each of the modifier. To determine the relationship between ACM oxidation mechanism and analytical usability of developed sensors, under optimized conditions, for both working electrodes calibration curves were developed, and the methods were applied to determine ACM in real samples. The performed studies confirm the need for rational design of used graphene-derivative materials as electrode surface modifiers.

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Chlorophyll sensitized (BiO)2CO3/ CdWO4/rGO nano-hybrid assembly for solar assisted photo-degradation of chlorzoxazone

Chandel

Thakur²,

Sharma³

et al. 2022

Chemosphere

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Multivariate Optimization of Separation Conditions for Simultaneous Determination of Acemetacin and Chlorzoxazone in a Pharmaceutical Preparation by HPLC Using Response Surface Methodology

Cited by 3 publications

References 0 publications

Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode

Differential Pulse Anodic Voltammetric Determination of Chlorzoxazone in Pharmaceutical Formulation using Carbon Paste Electrode

Tailoring Electrochemical Activity of Acemetacin with Electrocatalytic Properties of Graphene Derivatives

Chlorophyll sensitized (BiO)2CO3/ CdWO4/rGO nano-hybrid assembly for solar assisted photo-degradation of chlorzoxazone

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