Multivariate evaluation of doxorubicin surface-enhanced Raman spectra

Eliasson, Charlotte; Lorén, Anders; Murty, K. V. G. K.; Josefson, Mats; Käll, Mikael; Abrahamsson, Jonas; Abrahamsson, Katarina

doi:10.1016/s1386-1425(01)00453-x

Cited by 48 publications

(30 citation statements)

References 16 publications

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“…B–I). Both the A1 and the D1 SERS spectra agreed with other studies . The spectra of both A1 and D1 were found to be very similar with no distinctive differences in the vibrational bands observed; however, our UTLC platform easily separated the two compounds.…”

Section: Resultssupporting

confidence: 88%

Ultra‐thin layer chromatography with integrated silver colloid‐based SERS detection

Wallace

Lavrik

2016

Electrophoresis

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Simplified lab-on-a-chip techniques are desirable for quick and efficient detection of analytes of interest in the field. The following work involves the use of deterministic pillar arrays on the micro-scale as a platform to separate compounds, and the use of Ag colloid within the arrays as a source of increased signal via surface enhanced Raman spectroscopy (SERS). One problem traditionally seen with SERS surfaces containing Ag colloid is oxidation; however, our platforms are superhydrophobic, reducing the amount of oxidation taking place on the surface of the Ag colloid. This work includes the successful separation and SERS detection of a fluorescent dye compounds (resorufin and sulforhodamine 640), fluorescent anti-tumor drugs (Adriamycin and Daunomycin), and purine and pyrimidine bases (adenine, cytosine, guanine, hypoxanthine, and thymine).

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Section: Resultssupporting

confidence: 88%

Ultra‐thin layer chromatography with integrated silver colloid‐based SERS detection

Wallace

Lavrik

2016

Electrophoresis

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“…In case of doxorubicin-Au NPs complex the amine peak shifted to 3373 cm À1 , indicating the formation of electrostatic bond formation. Similar to infrared absorption spectroscopy, Raman scattering could be used for identification and quantification of molecule [13]. The surface-enhanced Raman scattering (SERS) has been used as a powerful method to get signal from fluorescent chromophores [26].…”

Section: Resultsmentioning

confidence: 99%

“…The drug exerts its antitumor effects through interaction with the DNA replicative system in the cell nucleus and its activity is highly dependent upon intracellular levels [13]. Doxorubicin conjugated Au NPs have the potential to simultaneously enhance CT imaging contrast and facilitate photothermal cancer therapy [14] and also showed enhanced cytotoxic effects on human glioma cell lines LN-18 and LN-229 [15].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of doxorubicin functionalized gold nanoparticles

Mirza

Shamshad

2011

European Journal of Medicinal Chemistry

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“…Anthracyclines, especially DNR and DOX have been widely investigated using various spectroscopic methods, e.g. Raman spectroscopy [24,25], Resonance Raman (RR) [26][27][28], Surface Enhanced Raman Spectroscopy (SERS) [29][30][31][32], UV-Vis absorption [26,33] and FT-IR absorption spectroscopy [24,34,35]. The visible absorption spectra of DOX and DNR are, however, almost identical, having a maximum of absorption near to 480-490 nm.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic studies of anthracyclines: Structural characterization and in vitro tracking

Szafraniec

Majzner

Farhane³

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A broad spectroscopic characterization, using ultraviolet-visible (UV-vis) and Fourier transform infrared absorption as well as Raman scattering, of two commonly used anthracyclines antibiotics (DOX) daunorubicin (DNR), their epimers (EDOX, EDNR) and ten selected analogs is presented. The paper serves as a comprehensive spectral library of UV-vis, IR and Raman spectra of anthracyclines in the solid state and in solution. The particular advantage of Raman spectroscopy for the measurement and analysis of individual antibiotics is demonstrated. Raman spectroscopy can be used to monitor the in vitro uptake and distribution of the drug in cells, using both 488 nm and 785 nm as source wavelengths, with submicrometer spatial resolution, although the cellular accumulation of the drug is different in each case. The high information content of Raman spectra allows studies of the drug-cell interactions, and so the method seems very suitable for monitoring drug uptake and mechanisms of interaction with cellular compartments at the subcellular level.

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Multivariate evaluation of doxorubicin surface-enhanced Raman spectra

Cited by 48 publications

References 16 publications

Ultra‐thin layer chromatography with integrated silver colloid‐based SERS detection

Ultra‐thin layer chromatography with integrated silver colloid‐based SERS detection

Preparation and characterization of doxorubicin functionalized gold nanoparticles

Spectroscopic studies of anthracyclines: Structural characterization and in vitro tracking

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