Multivariate data analysis on multisensor measurement for inline process monitoring of adenovirus production in HEK293 cells
Xingge Xu,
Omar Farnós,
Barbara C. M. F. Paes
et al.
Abstract:In the era of Biopharma 4.0, process digitalization fundamentally requires accurate and timely monitoring of critical process parameters (CPPs) and quality attributes. Bioreactor systems are equipped with a variety of sensors to ensure process robustness and product quality. However, during the biphasic production of viral vectors or replication‐competent viruses for gene and cell therapies and vaccination, current monitoring techniques relying on a single working sensor can be affected by the physiological st… Show more
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