Multivariate data analysis as a tool to investigate the reaction kinetics of intramolecular cyclization of enalapril maleate studied by isothermal and non-isothermal FT-IR microscopy

Widjaja, Effendi; Lim, Geok Hong; Tan, S.

doi:10.1016/j.ejps.2007.09.002

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…In ENM drug, bands in the region of 3054 to 2891 cm -1 were observed in the Raman spectrum of this compound which can be assigned as ν(CH) of aromatic ring, symmetric and asymmetry stretching modes of CH 2 and CH 3 groups. Other bands as carbonyl stretching of amide, carbonyl stretching of maleate and carbonyl stretching of ester were also observed (Widjaja et al, 2007). For LOS, the most important bands are observed at 807 and 819 cm -1 assigned to imidazole ring deformation and at 1489 cm -1 attributed to N=N stretching mode (Raghavan et al, 1993).…”

Section: Antihypertensive Drugs and Raman Spectramentioning

confidence: 81%

Structure Characterization of Materials by Association of the Raman Spectra and X-Ray Diffraction Data

Chagas¹,

Souza²,

Carmo³

et al. 2012

Vibrational Spectroscopy

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Section: Antihypertensive Drugs and Raman Spectramentioning

confidence: 81%

Structure Characterization of Materials by Association of the Raman Spectra and X-Ray Diffraction Data

Chagas¹,

Souza²,

Carmo³

et al. 2012

Vibrational Spectroscopy

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“…The FT-IR spectrum of enalapril maleate showed characteristic bands at 1749 cm −1 (C=O of the carboxylic group), 1645 cm −1 (C=O of the tertiary amide), 1578 cm −1 (C=O of the carboxylic acid of monohydrogen maleate) and 1225 cm −1 (C-C-O of acetate and ester) [ 43 , 44 ]. Characteristic bands for the dimethylamino groups of bPMMA could be found at 2822 cm −1 and 2770 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate

2022

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The aim of this research was the production of extrudates for the treatment of hypertension and heart failure and the investigation of the degradation of the peptidomimetic drug enalapril maleate (EM) during hot-melt extrusion (HME). A fast HPLC method was developed to quantify enalapril maleate and possible degradation products. Screening experiments revealed that the diketopiperazine derivative (Impurity D) was the main degradation product. Hot-melt extrusion of enalapril maleate with the polymer Soluplus® enabled extrusion at 100 °C, whereas a formulation with the polymer Eudragit® E PO could be extruded at only 70 °C. Extrusion at 70 °C prevented thermal degradation. A stabilizing molecular interaction between enalapril maleate and Eudragit® E PO was identified via FT-IR spectroscopy. Dissolution studies were carried out to study the influence of the formulation on the dissolution behavior of enalapril maleate. These promising results can be transferred to other thermo-sensitive and peptidomimetic drugs to produce extrudates which can be used, for instance, as feedstock material for the production of patient-specific dosage forms via Fused Deposition Modeling (FDM) 3D printing.

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“…In addition, Widjaja et al had successfully used the multivariate data analysis approach based on entropy minimization and spectral dissimilarity to investigate the solid-state kinetics of intramolecular cyclization of enalapril maleate via thermal FTIR microscopy [ 135 ]. The infrared spectra of enalapril maleate and DKP were reconstructed.…”

Section: Simultaneous Dsc-ftir Microspectroscopymentioning

confidence: 99%

Current and Potential Applications of Simultaneous DSC-FTIR Microspectroscopy for Pharmaceutical Analysis

Lin¹

2021

Journal of Food and Drug Analysis

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Quality control (QC) is the most important key issue in the pharmaceutical industry to ensure the quality of drug products. Many analytical instruments and techniques in pharmaceutical analysis are applied to assess the quality and quantity of the drugs. In the current and future trends, a combination of digitization, automation and hyphenation with high throughput on-line performance will be the topics for the future of pharmaceutical QC. The hyphenated analytical techniques have recently received great attention as unique means to solve complex analytical problems in a short period of time. This review article is an update on the recent potential applications of hyphenated technique developed from the coupling of a rapid separation or induction technique (differential scanning calorimetry; DSC) and an on-line spectroscopic (Fourier transform infrared; FTIR) detection technology to carry out an one-step solid-state analysis in pharmaceutical formulation developments, including (1) intramolecular condensation of pharmaceutical polymers, (2) intramolecular cyclization of drugs and sweetener, (3) polymorphic transformation of drugs and excipients, (4) drug-polymer (excipient) interaction, (5) fast cocrystal screening and formation. This simultaneous DSC-FTIR microspectroscopy can also provide an easy and direct method for one-step screening and qualitative detection of drug stability in real time.

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Multivariate data analysis as a tool to investigate the reaction kinetics of intramolecular cyclization of enalapril maleate studied by isothermal and non-isothermal FT-IR microscopy

Cited by 8 publications

References 27 publications

Structure Characterization of Materials by Association of the Raman Spectra and X-Ray Diffraction Data

Structure Characterization of Materials by Association of the Raman Spectra and X-Ray Diffraction Data

Hot-Melt Extrusion of the Thermo-Sensitive Peptidomimetic Drug Enalapril Maleate

Current and Potential Applications of Simultaneous DSC-FTIR Microspectroscopy for Pharmaceutical Analysis

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