Multivariate curve resolution-alternating least squares to study the simultaneous release of Sumatriptan and Naproxen from the polymeric substrate

Dadashi, Reza; Bahram, Morteza; Moghtader, Mehdi

doi:10.1007/s13738-019-01828-7

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…For drug delivery systems that follow this model, the release rate is independent of drug concentration. In other words, drug release is constant throughout the delivery time in the blood ow [44]. The Zero-order kinetic can be represented by the following equation.…”

Section: Zero Order Modelmentioning

confidence: 99%

Chitosan capped MSNs as a carrier of quercetin: Preparation, release kinetic study and cytotoxicity assay on osteosarcoma cancer cell line

Keshavarz

Nasab

Mozafari

2023

Preprint

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Mesoporous silica nanoparticles (MSNs) have received particular attention in drug delivery applications during recent years. In this study, we successfully synthesized MCM-41 MSNs by sol-gel method. Chitosan polymer as a pH-sensitive capping was coated on MSNs by (3-Glycidyloxypropyl)trimethoxysilane (GPTMS) crosslinker and quercetin (Que) as a compound with anticancer properties was loaded into prepared nanoparticles (Que@Cs-MSNs) for the first time. The structural characteristics and physicochemical properties were investigated by small-angle X-ray diffraction (SAXS), Nitrogen adsorption-desorption, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM) and Fourier transform infrared (FTIR) methods. Accordingly, the pore size of the hexagonal silica structure was found to be about 3.5 nm, and the dimensions of the Que@Cs-MSNs were calculated to be about 185 nm. The release behavior and release kinetics were studied at pH of 5 and 7.4 and the results showed that the presence of the chitosan coating due to its pH-sensitive nature, in addition to affecting the release rate, caused a change in the release kinetics due to swelling in acidic pH. Also, the results of the cytotoxicity test using MTT assay demonstrated that Que@Cs-MSNs show a higher anticancer effect compared to free Que against G-292 osteosarcoma cancer cells after 72 hours of incubation.

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Section: Zero Order Modelmentioning

confidence: 99%

Chitosan capped MSNs as a carrier of quercetin: Preparation, release kinetic study and cytotoxicity assay on osteosarcoma cancer cell line

Keshavarz

Nasab

Mozafari

2023

Preprint

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“…While this method has been used extensively in the field of chemical kinetics, 9 its application in the drug release studies has been limited to determining the release profiles of NPs loaded with multiple spectrally active compounds. 10 In this work, we present a method for determining the release kinetics of unstable molecules that is a combination of ALS and multilinear regression. We apply this method to determine the release kinetics of flavonoids, molecules that undergo autoxidation under physiological conditions, from the superparamagnetic NPs.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Alternating least squares (ALS) is a powerful and robust data analysis method that can be used to obtain the characteristic spectra of the unstable intermediates, as well as the spectra of the compounds in mixtures of variable composition in general. While this method has been used extensively in the field of chemical kinetics, its application in the drug release studies has been limited to determining the release profiles of NPs loaded with multiple spectrally active compounds . In this work, we present a method for determining the release kinetics of unstable molecules that is a combination of ALS and multilinear regression.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Flavonoid Degradation and Controlled Release from Functionalized Magnetic Nanoparticles

Sadžak,

Eraković,

Šegota

2023

Mol. Pharmaceutics

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Flavonoids are naturally occurring antioxidants that have been shown to protect cell membranes from oxidative stress and have a potential use in photodynamic cancer treatment. However, they degrade at physiological pH values, which is often neglected in drug release studies. Kinetic study of flavonoid oxidation can help to understand the mechanism of degradation and to correctly analyze flavonoid release data. Additionally, the incorporation of flavonoids into magnetic nanocarriers can be utilized to mitigate degradation and overcome their low solubility, while the release can be controlled using magnetic fields (MFs). An approach that combines alternating least squares (ALS) and multilinear regression to consider flavonoid autoxidation in release studies is presented. This approach can be used in general cases to account for the degradation of unstable drugs released from nanoparticles. The oxidation of quercetin, myricetin (MCE), and myricitrin (MCI) was studied in PBS buffer (pH = 7.4) using UV− vis spectrophotometry. ALS was used to determine the kinetic profiles and characteristic spectra, which were used to analyze UV−vis data of release from functionalized magnetic nanoparticles (MNPs). MNPs were selected for their unique magnetic properties, which can be exploited for both targeted drug delivery and control over the drug release. MNPs were prepared and characterized by X-ray diffraction, infrared spectroscopy, scanning electron microscopy, superconducting quantum interference device magnetometer, and electrophoretic mobility measurements. Autoxidation of all three flavonoids follows a two-step first-order kinetic model. MCE showed the fastest degradation, while the oxidation of MCI was the slowest. The flavonoids were successfully loaded into the prepared MNPs, and the drug release was described by the first-order and Korsmeyer−Peppas models. External MFs were utilized to control the release mechanism and the cumulative mass of the flavonoids released.

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Development of doxorubicin-encapsulated magnetic liposome@PEG for treatment of breast cancer in BALB/c mice

Maghsoudi

Hosseini

Soraya

et al. 2023

Drug Deliv. and Transl. Res.

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Multivariate curve resolution-alternating least squares to study the simultaneous release of Sumatriptan and Naproxen from the polymeric substrate

Cited by 5 publications

References 31 publications

Chitosan capped MSNs as a carrier of quercetin: Preparation, release kinetic study and cytotoxicity assay on osteosarcoma cancer cell line

Chitosan capped MSNs as a carrier of quercetin: Preparation, release kinetic study and cytotoxicity assay on osteosarcoma cancer cell line

Kinetics of Flavonoid Degradation and Controlled Release from Functionalized Magnetic Nanoparticles

Development of doxorubicin-encapsulated magnetic liposome@PEG for treatment of breast cancer in BALB/c mice

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