Multivariate Correlation Analysis Suggested High Ubiquinol and Low Ubiquinone in Plasma Promoted Primate ’ s Social Motivation and IR Detected Lower Body Temperature

Abstract

Mental problems caused by various kinds of stress induce neurotoxic damage through biological mechanisms like oxidation or metabolic unbalancing. We evaluated the dietary supplementation of antioxidant and nutrition, ubiquinol with milk in normal isolated adult common marmoset (Callithrix jacchus) as a preliminary preclinical study. The primates were fed with milk with or without ubiquinol every day for three months and after a two-month-interval, the treatment conditions were alternated. Psycho-physiological state was evaluated by video-recording of social behavior, body temperature detection by a simple IR thermal camera and a blood glucose chip-sensor. Furthermore, social behavior data were information-processed by technology to integrate multiple factors, 'Behavior output analysis for quantification of emotional state translation' abbreviated as BOUQUET, which visualized a statistical partial space where the status of high ubiquinol and low ubiquinone in plasma strongly correlated with high frequency of social approaching behavior and lower body temperatures in a social meeting context. This analysis also suggested that high frequency of face direction to a peer correlated with the high ubiquinol-low ubiquinone and high variation of body temperature. Blood glucose seemed weakly relevant to alert behavior in this multiple correlation. These results imply that unbiquinol supplementation promotes social motivation. Finally, the result that the BOUQUET and the sensor systems revealed the implicit psycho-physiological information suggests its applicability in various toxico-psychopathological studies as quantitative manner.

Socio-emotional development evaluated by Behaviour Output analysis for Quantitative Emotional State Translation (BOUQUET): Towards early diagnosis of individuals with developmental disorders

“…From the recorded WAVE and JPEG files per second, the parameters (animals: the x, y coordinate of head centre, forehead direction, the horizontal or rotation velocity of head, local preference, pecking and vocal call behaviours that had previously identified four spectrogram patterns depending on socio-emotional contexts; human infant; the X, Y specific points of arthrometry: head, trunk, arms and legs). Multiple parameters were integrated by BOUQUET [9][10][11][12][13][14][15][16][17][18][19] with PCA based on a correlation matrix for general chicks' data plots were allocated in the first quadrant at P3, which was featured as socially affiliated by the factor loading vectors, such as approaching to peers, facing peers and positive calls (not a distress-type call but a pleasure call) 9 .…”

“…The subject's behaviour was tested 1 day before brain sampling. oped based on principal component analysis (PCA) [9][10][11][12][13][14][15][16][17][18][19] . One drawback of the quantification is the tendency to ignore qualitative difference among patients.…”

“…To link both quantitative and qualitative information, an experimental animal model of psychological development was studied with multivariate analysis. Considering comparative simulation of emotional behaviour, we chose two diurnal, rich-vocalised species with full of homologous priorities for developmental neurobiological psychiatry 18 domestic fowl chicks (Gallus gallus domesticus) 8-13,18-21 from avian 22 and common marmosets (Callithrix jacchus) 8,[14][15][16][17][18] . This article presents the result of two lines of experimental animal studies.…”

Potential of a smartphone as a stress-free sensor of daily human behaviour

“…In the situation of the current study, it was confirmed that the psychological scores of warmth sensation and work efficiency changed in parallel. These results inferred the possibility that psychological modulation might be represented in these complex behavioural patterns as reported previously [1][2][3][4][5][6][7][8][9][10][11]28] and suggested evaluation in human workers including simple shift, acceleration and several ten-second-order cyclic motion. The current study investigated whether the technology could represent not only the commonality but also the individuality that needs to be recognized in all psychological and psychiatric fields.…”

“…We have employed a multivariate analytic methodology of behavioural http://dx.doi.org/10.1016/j.bbr.2014.06.007 0166-4328/© 2014 Elsevier B.V. All rights reserved. output analysis for quantitative emotional state translation called 'Bouquet', with multiple factors being measured from video images and sounds of humans and model animals [1][2][3][4][5][6][7][8][9][10][11]. Non-contact sensors such as video cameras are suited to psychological detection because they do not introduce artefacts of stress through attachment.…”