Multivariate Assessment of the Effect of Pump Design and Pump Gap Design Parameters on Blood Trauma

Graefe, Roland; Henseler, Andreas; Steinseifer, Ulrich

doi:10.1111/aor.12603

Cited by 23 publications

(19 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…) are established by two custom built laboratory pumps. The underlying hydraulic designs are created based on results and experience from previous studies .…”

Section: Methodsmentioning

confidence: 99%

The Effect of LVAD Pressure Sensitivity on the Assisted Circulation Under Consideration of a Mitral Insufficiency: An In Vitro Study

Graefe¹,

Beyel²,

Henseler³

et al. 2018

Artificial Organs

Self Cite

View full text Add to dashboard Cite

Current left ventricular assist devices (LVADs) differ with respect to their pump characteristics as described by the pump characteristic curve (also called HQ‐curve). Pressure sensitive LVADs depict a flat characteristic curve while most available LVADs have a steep, less pressure sensitive characteristic curve. This in vitro study investigated the effect of LVAD pressure sensitivity with a focus on the afterload of the right ventricle (RV) which is one out of many factors influencing right heart failure (RHF). To this end, two laboratory pumps differing in pressure sensitivity were tested as LVAD in an established, active mock circulation loop (MCL). The MCL represented patients with left heart failure and mitral insufficiency as another contributing factor to RV afterload. The results show that the pressure‐volume loop (PV‐loop) of the left ventricle (LV) undergoes a leftward and thus somewhat of a downward‐shift for highly pressure sensitive support. Consequently, the LV is unloaded to a higher degree at comparable arterial blood pressure and identical cardiac output, pulmonary and systemic vascular resistance and ventricular contractility. This causes a concomitant decrease of RV afterload. This effect seems to be due to increased unloading during systole. In case of a severe concomitant mitral insufficiency and looking at left atrial pressure, the difference is 18.5%. Without mitral insufficiency, the difference is reduced to 10.2%.

show abstract

“…) are established by two custom built laboratory pumps. The underlying hydraulic designs are created based on results and experience from previous studies .…”

Section: Methodsmentioning

confidence: 99%

The Effect of LVAD Pressure Sensitivity on the Assisted Circulation Under Consideration of a Mitral Insufficiency: An In Vitro Study

Graefe¹,

Beyel²,

Henseler³

et al. 2018

Artificial Organs

Self Cite

View full text Add to dashboard Cite

show abstract

“…Further influences on the haemolysis level are the bearing diameter, the gap length, the circumferential speed and the pressure difference between inflow and outflow. 15 When designing a hydrodynamic axial bearing, the geometry of the grooves in the counter-plate of the bearing in the pump casing proved to be decisive for the haemolysis level. By means of an appropriate design, a larger bearing gap is created when the rotor rotates so that the shear load on the blood is reduced and thus also haemolysis.…”

Section: Haemolysis In Blood Pumpsmentioning

confidence: 99%

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Köhne

2020

Perfusion

View full text Add to dashboard Cite

Since the use of continuous flow blood pumps as ventricular assist devices is standard, the problems with haemolysis have increased. It is mainly induced by shear stress affecting the erythrocyte membrane. There are many investigations about haemolysis in laminar and turbulent blood flow. The results defined as threshold levels for the damage of erythrocytes depend on the exposure time of the shear stress, but they are very different, depending on the used experimental methods or the calculation strategy. Here, the results are resumed and shown in curves. Different models for the calculation of the strengths of erythrocytes are discussed. There are few results reported about tests of haemolysis in blood pumps, but some theoretical approaches for the design of continuous flow blood pumps according to low haemolysis have been investigated within the last years.

show abstract

“…In the CFD simulation, numerical calculations are performed on the blood pump model, and the calculated results are used to estimate the circulation performance and blood damage [8][9][10]. However, there are many structural parameters of blood pumps, and the influencing characteristics of each parameter are often non-linear, and the parameters may also interact with each other [11,12]. Using only CFD simulation to determine the optimal parameters of the structure will require a lot of calculations, which will lead to a significant increase in time cost.…”

Section: Introductionmentioning

confidence: 99%

Multiple Parameters and Target Optimization of Splitter Blades for Blood Pumps Using CFD and Neural Networks

Yu¹,

Tan²,

Wang³

2020

Preprint

View full text Add to dashboard Cite

Background: The splitter blade is an improved structure effective in traditional pumps. However, applying splitter blades to blood pumps is a complex optimization problem with multiple parameters and objectives, because structural parameters, blood circulation dynamics, and blood damage need to be considered simultaneously. This study aims to obtain the performance impact of the splitter blade and make it well used in blood pumps through CFD and neural networks.Results: This study combines CFD and neural networks. And hydraulic experiments and PIV technology were used. In the optimization study, the number of blades, axial length, and circumferential offset are optimization parameters, and hydraulic performance and hemolytic prediction index are optimization targets. The study analyzes the influence of each parameter on performance and completes the optimization of the parameters. In the results, the optimal parameters of the number of blades, axial length ratio, and circumferential offset are 2, 6 °, and 0.41, respectively. Under optimized parameters, hydraulic performance can be significantly improved. And the results of hemolysis prediction and micro PIV experiments reflect that there is no increase in the risk of hemolytic damage.Conclusion: This study provides a method and ideas for improving the structure of the blood pump. The established optimization method can be effectively applied to the design and research of blood pumps with complex, high precision, and multiple parameters and targets.

show abstract

Multivariate Assessment of the Effect of Pump Design and Pump Gap Design Parameters on Blood Trauma

Cited by 23 publications

References 13 publications

The Effect of LVAD Pressure Sensitivity on the Assisted Circulation Under Consideration of a Mitral Insufficiency: An In Vitro Study

The Effect of LVAD Pressure Sensitivity on the Assisted Circulation Under Consideration of a Mitral Insufficiency: An In Vitro Study

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Multiple Parameters and Target Optimization of Splitter Blades for Blood Pumps Using CFD and Neural Networks

Contact Info

Product

Resources

About