Multivariate analysis of the twenty-year follow-up of the Donolo-Tel Aviv Prospective Coronary artery disease study and the usefulness of high density lipoprotein cholesterol percentage

Livshits, Gregory; Weisbort, Joshua; Meshulam, Nissim; Brunner, D.

doi:10.1016/0002-9149(89)90250-6

Cited by 40 publications

(8 citation statements)

References 13 publications

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“…Third, only analyses that provided multivariate-adjusted relative risk assessments for the association of low levels of HDL-C and CVD were considered. As a result, six additional studies [15][16][17][18][19][20], for which the primary outcome assessment was a univariate comparison of mean HDL-C levels in patients who did and did not subsequently develop CVD, were excluded from the review. Additional studies which focused on ratios [23,114,117], combined lipid parameters [24,108,109], or protein constituents of HDL-C [21,22] as well as studies that cohort were considered, all five meta-analysis studies and all five systematic and nonsystematic reviews were excluded [4][5][6][7][8][154][155][156][157][158].…”

Section: Methodsmentioning

confidence: 99%

Prospective studies on the relationship between high-density lipoprotein cholesterol and cardiovascular risk: a systematic review

Chirovsky

Fedirko

Cui³

et al. 2009

European Journal of Cardiovascular Prevention & Rehabilitat

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Epidemiological studies have extensively evaluated the association between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD) risk. The objective of this systematic review was to enumerate the number of original prospective studies that showed a significant association between HDL-C and CVD risk and provided evidence of the consistency of this association across other lipid risk factors. A systematic MEDLINE literature search identified 53 prospective cohort and five nested case-control studies that provided multivariate assessments of the association between HDL-C and CVD risk. Among these 58 prospective studies, 31 studies found a significant inverse association between HDL-C and CVD risk for all CVD outcomes and subpopulations studied, whereas 17 studies found a significant association for some CVD outcomes and/or subpopulations assessed. The ratio of studies that found a significant association out of the total studies identified was similar across all CVD outcomes, although there was less evidence for stroke and atherosclerotic outcomes. Only seven studies tested for the consistency of this association across other lipid risk factors, of which six studies suggested that the association was consistent across other lipid levels. In conclusion, the association between HDL-C and CVD risk is significant and strong, although further evidence may be needed to establish whether this association is consistent across other lipid risk factors. Furthermore, uncertainties remain regarding the mechanism in which HDL-C exerts its effects, suggesting a need for further research focused on new methods for reliable measurement.

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Section: Methodsmentioning

confidence: 99%

Prospective studies on the relationship between high-density lipoprotein cholesterol and cardiovascular risk: a systematic review

Chirovsky

Fedirko

Cui³

et al. 2009

European Journal of Cardiovascular Prevention & Rehabilitat

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“…40 However, 9 of 10 prospective observational studies have reported a positive association between total cholesterol levels and coronary heart disease in women. [41][42][43][44][45][46][47][48][49][50] An increased level of high-density lipoprotein (HDL) cholesterol is a particularly strong predictor of a decreased risk of coronary heart disease in women. 41,43,44 HDL cholesterol was second only to age as a predictor of death from cardiovascular causes among women in the Lipid Research Clinics Follow-up Study.…”

Section: Cholesterolmentioning

confidence: 99%

“…[41][42][43][44][45][46][47][48][49][50] An increased level of high-density lipoprotein (HDL) cholesterol is a particularly strong predictor of a decreased risk of coronary heart disease in women. 41,43,44 HDL cholesterol was second only to age as a predictor of death from cardiovascular causes among women in the Lipid Research Clinics Follow-up Study. 43 Whereas more than 10,000 men with preexisting coronary heart disease have been enrolled in trials of cholesterol reduction, 51-54 just over 400 women have been included in such secondary-prevention trials.…”

Section: Cholesterolmentioning

confidence: 99%

The Primary Prevention of Coronary Heart Disease in Women

et al. 1995

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“…Apolipoprotein B (APO-B) in turn is the principal component of the protein moiety in LDL-C (low-density lipoprotein) and is the ligand for the binding of LDL-C to its receptor. Both HDL-C and LDL-C are well known strong predictors for coronary artery disease [e.g., Livshits et al, 1989;Berliner and Haberland, 1993;Schmitz and Lackner, 19931. Therefore, it is not unexpected that these components will show similar association with CAD.…”

Section: Introductionmentioning

confidence: 99%

Tel Aviv–Heidelberg three‐generation offspring study: Genetic determinants of apolipoprotein A1 and apolipoprotein B

et al. 1995

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The contribution of major gene and multifactorial effects on variation of plasma apolipoproteins A1 and B has been tested in a large sample of population-based Israeli pedigrees. Our most parsimonious and best fitting model for both apolipoproteins is consistent with Mendelian transmissibility, with significant contribution of major genes (with 2 alleles recessive and dominant within each locus) and polygenes, but neglects effects of common sib environment as well as related intergeneration differences in polygenic effects. Total genetic effects explain 71 and 58% of phenotypic variance of APO-A1 and APO-B levels. The major genes account for about 44 and 32% of the variance in APO-A1 and APO-B, respectively, and the frequency of the recessive alleles determining the high level of apolipoproteins under the study in the Israeli population is in the vicinity of 40% at each locus.

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Multivariate analysis of the twenty-year follow-up of the Donolo-Tel Aviv Prospective Coronary artery disease study and the usefulness of high density lipoprotein cholesterol percentage

Cited by 40 publications

References 13 publications

Prospective studies on the relationship between high-density lipoprotein cholesterol and cardiovascular risk: a systematic review

Prospective studies on the relationship between high-density lipoprotein cholesterol and cardiovascular risk: a systematic review

The Primary Prevention of Coronary Heart Disease in Women

Tel Aviv–Heidelberg three‐generation offspring study: Genetic determinants of apolipoprotein A1 and apolipoprotein B

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