Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring

Blay, Jean‐Yves; Lasset, Christine; Carrié, C.; Chauvin, Franck; Coiffier, Bertrand; Gisselbrecht, Christian; Clavel, M.; Rebattu, P.; Brunat‐Mentigny, M.; Philip, Thierry

doi:10.1038/bjc.1993.209

Cited by 38 publications

(12 citation statements)

References 26 publications

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“…20 None of the clinical or histologic criteria examined had a prognostic influence on survival; however, we did not consider all clinical variables such as performance status or level of protein in the cerebrospinal fluid. 16 This work is being continued by the GOELAMS group for a larger series. The expression of bcl-2 was reported to be linked to a poor prognosis for disease-free survival in diffuse large B-cell systemic lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Camilleri-Broët

Martin

Moreau³

et al. 1998

Am J Clin Pathol

154

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A b s t r a c tRecent studies suggest that the incidence of primary central nervous system lymphomas (PCNSLs) is increasing. A few decades ago, PCNSLs accounted for only 1% of all primary intracranial neoplasms. Today, however, they represent between 2% and 6% of all primary brain neoplasms and more than 1% of all non-Hodgkin lymphomas. This trend does not seem totally explained by improved diagnostic techniques or by HIV infection. A substantial increase in PCNSLs among immunocompetent patients has been observed.'"* Most PCNSLs are characterized by a diffuse proliferation of large B cells. 7 Follow-up usually shows a rapid local relapse. Systemic dissemination has been described only rarely. The prognosis remains poor even though some long-term survival has been reported. 38The frequency of each histologic subtype is variable from 1 series to another, and little is known about their biologic characteristics. In a previous article, 9 we reported the major features of 51 AIDS-related PCNSLs. In the present study, we reviewed 72 PCNSLs occurring in immunocompetent patients and studied their clinical and morphologic characteristics, immunophenotype (including expression of bcl-2 and p53), and Epstein-Barr virus (EBV) status. We also studied the impact of these different variables on patient survival. Material and Methods PatientsSeventy-two PCNSLs were studied, including 40 in patients who were part of the lymphomes cerebraux primitifs

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Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Camilleri-Broët

Martin

Moreau³

et al. 1998

Am J Clin Pathol

154

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“…The prognosis of nonselected patients with PCNSL is comparable to that of glioblastoma multiforme patients, with a 5-year survival rate after conventional chemotherapy and radiotherapy (RT) usually at less than 10% [11]. Unfavorable prognostic factors for survival are more than 60 years of age, WHO performance status greater than 2, poor neurologic function, elevated serum lactate dehydrogenase, extensive tumor spread, CSF protein level greater than 0.6 g/L, corticosteroid dependence, and absence of chemotherapy administration [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Primary cerebellar B cell lymphoma: A case report

Datta¹,

Gupta²,

Choudhury³

et al. 2013

IJCRI

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Introduction: Primary central nervous system lymphoma (PcNsL) is usually a diffuse large b cell non-Hodgkin lymphoma that originates in the brain, spinal cord, leptomeninges or eyes. Primary central nervous system lymphoma is a rare malignant tumor comprising less than 3% of all primary brain tumors. the PcNsL in immunocompetent patients is most commonly supratentorial, found adjacent to the ventricular surfaces and in deep white matter and subcortical structures, such as the basal ganglia, thalamus and corpus callosum. the lesion is single in 60-70% of patients. Lesions are located in the hemispheres (38%), thalamus/basal ganglia (16%), corpus callosum (14%), periventricular region (12%) and cerebellum (9%). Herein, we report an extremely rare case of a primary cNs b cell lymphoma involving cerebellum. case report: A 55-year-old female was presented with vomiting, ataxia and disorientation. t2-

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“…Some even have argued that age may influence the outcome more than treatment (21). High LDH level has been a common indicator of aggressiveness and poor prognosis for all subtypes of NHL (22). Factors specific to PCNSL include elevation of CSF protein which has been shown to correlate strongly with poorer survival (22).…”

Section: Prognosismentioning

confidence: 99%

“…High LDH level has been a common indicator of aggressiveness and poor prognosis for all subtypes of NHL (22). Factors specific to PCNSL include elevation of CSF protein which has been shown to correlate strongly with poorer survival (22). Location of tumor in deeper structures of the brain predicts worse outcomes (22).…”

Section: Prognosismentioning

confidence: 99%

“…Factors specific to PCNSL include elevation of CSF protein which has been shown to correlate strongly with poorer survival (22). Location of tumor in deeper structures of the brain predicts worse outcomes (22). The International Extranodal Lymphoma Study Group (IELSG) prognostic score consists of the 5 parameters mentioned above, according to which patients are divided into 3 risk groups (23)…”

Section: Prognosismentioning

confidence: 99%

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Limited role of surgery in the management of primary central nervous system lymphoma (Review)

Cheng¹,

Zhang²,

Zhang³

et al. 2009

Oncol Rep

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Abstract. Primary central nervous system lymphoma (PCNSL) is a nervous-system-seeking extranodal nonHodgkin's lymphoma whose incidence has increased in both immunocompromised and immunocompetent patients. Corticosteroids are used for symptomatic management but can interfere with pathological diagnosis. The well-established treatments such as radiotherapy, chemotherapy or a combination of both remain the mainstays. Traditionally, the most important role for surgery is to obtain and sample adequate tissue to confirm a diagnosis with stereotactic biopsy. Though no benefit could be demonstrated for debulking surgery, a subset of patients with large space occupying lesions which could be well circumscribed and surgically accessible may benefit from tumor resection. Moreover, surgical procedures to carry out interstitial chemotherapy and/or brachytherapy with or without tumor resection hold promise. Complications such as hydrocephalus could be managed by ventriculoperitoneal shunting. Further application of surgical procedures in the treatment of PCNSL is recommended with caution and strict patient selection criteria, and should be used in combination with radiotherapy and/or chemotherapy.

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Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring

Abstract: Summary Between 1982 and 1991, 41

Cited by 38 publications

References 26 publications

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Primary Central Nervous System Lymphomas in 72 Immunocompetent Patients: Pathologic Findings and Clinical Correlations

Primary cerebellar B cell lymphoma: A case report

Limited role of surgery in the management of primary central nervous system lymphoma (Review)

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