Multivariate Analysis of Molecular Indicators for Postoperative Liver Metastasis in Colorectal Cancer Cases

c-MET Overexpression in Colorectal Cancer: A Poor Prognostic Factor for Survival

“…Mesenchymal-epithelial transition factor gene overexpression has been reported to vary from 10% to 75% in CRC. [19][20][21][22][23][24][25] Several studies have reported significant overexpression of c-MET mRNA and protein in CRC tumors compared with adjacent normal colon mucosa. 19 c-MET overexpression is considered to be related to advanced stage and distant metastases and to predict a poor prognosis.…”

Down-regulated MYH11 Expression Correlates with Poor Prognosis in Stage II and III Colorectal Cancer

“…Among them, finding biomarkers for prognosis has long been a hotspot (Huang et al, 2012;Qian et al, 2012;Zhang et al, 2012;Chen et al, 2013;Cui et al, 2013;Dong et al, 2013;Sisik et al, 2013;Wu et al, 2013). Myosins have a well-characterized biological function in using the energy of ATP hydrolysis to move actin filaments to produce muscle force.…”

Circulating Levels of VEGF and CXCL1 Are Predictive of Metastatic Organotropismin in Patients with Colorectal Cancer

“…serum or plasma) has been found in solid and hematological malignancies of various origins and is associated with metastasis formation and poor prognosis (15,16). By multivariate analysis of molecular markers for detection of liver metastases after surgery in patients with colorectal cancer, it was demonstrated that a combination of markers such as carcinoembryonic antigen (CEA), epidermal growth factor receptor (EGFR) and VEGF could be an effective method for predicting liver metastases in patients with colorectal cancer (17).…”