Multivariate Analysis of Individual Bacterial Outer Membrane Vesicles Using Fluorescence Microscopy
Aarshi N. Singh,
Justin B Nice,
Meishan Wu
et al.
Abstract:Gram-negative bacteria produce outer membrane vesicles (OMVs) that play a critical role in cell−cell communication and virulence. OMVs have emerged as promising therapeutic agents for various biological applications such as vaccines and targeted drug delivery. However, the full potential of OMVs is currently constrained by inherent heterogeneities, such as size and cargo differences, and traditional ensemble assays are limited in their ability to reveal OMV heterogeneity. To overcome this issue, we devised an … Show more
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