Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomy

Takeda, Naokazu; Sakuragi, Noriaki; Takeda, Mahito; Okamoto, Kazuhira; Kuwabara, Makoto; Negishi, H.; Oikawa, Mamoru; Yamamoto, Ritsu; Yamada, Hideto; Fujimoto, Seiichiro

doi:10.1034/j.1600-0412.2002.811208.x

Cited by 175 publications

(129 citation statements)

References 25 publications

(32 reference statements)

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“…histologic type, histologic grade, tumor size, depth of stromal invasion, LVSI, venous invasion, parametrial involvement, lymph node metastasis, vaginal involvement, or invasive pattern), or ancillary investigation results (i.e. DNA index by flow cytometry or HPV18 detection) (Kamura et al, 1992;Sevin et al, 1996;Lai et al, 1999;Trattner et al, 2001;Takeda et al, 2002;Grisaru et al, 2003;Ayhan et al, 2004;Ho et al, 2004;Shinohara et al, 2004;Lai et al, 2007;Metindir and Bilir, 2007;Sartori et al, 2007;Behtash et al, 2009;Biewenga et al, 2009;2011). When applied to our patient population, only two of these prognostic models by Shinohara et al (2004) and Ho et al (2004) could identify the patient group with a significantly higher recurrence rate than the remaining cases (p<0.05).…”

Section: Prognostic Model In Patients With Early-stage Squamous Cell mentioning

confidence: 99%

Prognostic Model in Patients with Early-stage Squamous Cell Carcinoma of the Uterine Cervix: A Combination of Invasive Margin Pathological Characteristics and Lymphovascular Space Invasion

Khunamornpong

Lekawanvijit²,

Settakorn³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: This study aimed to develop a prognostic model in patients with early-stage cervical squamous cell carcinoma based on clinicopathological features, including invasive margin characteristics. Materials and Methods: Clinicopathological features and outcomes of 190 patients with FIGO stage IB-IIA cervical squamous cell carcinoma treated by surgery were collected and analyzed for factors associated with tumor recurrence. In addition to well-recognized pathological risk factors, the pathological characteristics of invasive margin (type of invasive pattern and degree of stromal desmoplasia and peritumoral inflammatory reaction) were also included in the analysis. Multiple scoring models were made by matching different clinicopathological variables and/ or different weighting of the score for each variable. The model with the best performance in the prediction of recurrence and decreased survival was selected. Results: The model with the best performance was composed of a combined score of invasive pattern, lymphovascular space invasion (LVSI), and degree of inflammatory reaction and stromal desmoplasia (total score =10). Compared to those with score ≤8, the patients with score 9-10 had a significantly higher recurrence rate in the overall group (p<0.001) and the subgroup without adjuvant therapy (p<0.001), while the significance was marginal in the subgroup with adjuvant therapy (p=0.069). In addition, the patients with score 9-10 had a higher rate of tumor recurrence at distant sites (p=0.007). The disease-free survival was significantly lower in the patients with score 9-10 than those with score ≤8 among the overall patients (p<0.001), in the subgroup without adjuvant therapy (p<0.001), and the subgroup with adjuvant therapy (p=0.047). Conclusions: In this study, a prognostic model based on a combination of pathological characteristics of invasive margin and LVSI proved to be predictive of tumor recurrence and decreased disease-free survival in patients with early-stage cervical squamous cell carcinoma.

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Section: Prognostic Model In Patients With Early-stage Squamous Cell mentioning

confidence: 99%

Prognostic Model in Patients with Early-stage Squamous Cell Carcinoma of the Uterine Cervix: A Combination of Invasive Margin Pathological Characteristics and Lymphovascular Space Invasion

Khunamornpong

Lekawanvijit²,

Settakorn³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…A US study of patients from 1997 to 2003 in the SEER database found 5-year overall survivals of 32.5% for patients with SNEC, 74.3% for ADC and 64.6% for SCC (Chen et al, 2008). Some studies have reported 2.6-2.9 times higher mortality among patients with early stage ADC compared with early-stage SCC patients over 10-19 years of follow-up (Nakanishi et al, 2000;Takeda et al, 2002;Park et al, 2010;Mabuchi et al, 2012) while others have not found any significant difference in survival among patients with SCC and ADC (Shingleton et al, 1995;Lee et al, 2006;Fregnani et al, 2008;Kasamatsu et al, 2009;Narukon et al, 2010). Moreover, only few studies have included patients with SNEC.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported that histological type is an important prognostic factor (Nakanishi et al, 2000;Takeda et al, 2002;Vinh-Hung et al, 2007;Chen et al, 2008;Zivanovic et al, 2009;Lee et al, 2010;Park et al, 2010). A US study of patients from 1997 to 2003 in the SEER database found 5-year overall survivals of 32.5% for patients with SNEC, 74.3% for ADC and 64.6% for SCC (Chen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

Intaraphet

Kasatpibal²,

Siriaunkgul³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the third most common cancer among women worldwide, accounting for approximately 13% of all cancers in women, with 529,800 new cases and 275,100 deaths in 2008. More than 85% of the cases and about 88% of all deaths occurred in developing countries (Ferlay, 2010;Jemal et al., 2011). At the same time, the incidence of cervical cancer has decreased dramatically in developed countries with well-developed screening programs concomitant with substantial survival AbstractBackground: Clarifying the prognostic impact of histological type is an essential issue that may influence the treatment and follow-up planning of newly diagnosed cervical cancer cases. This study aimed to evaluate the prognostic impact of histological type on survival and mortality in patients with cervical squamous cell carcinoma (SCC), adenocarcinoma (ADC) and small cell neuroendocrine carcinoma (SNEC). Materials and Methods: All patients with cervical cancer diagnosed and treated at Chiang Mai University Hospital between January 1995 and October 2011 were eligible. We included all patients with SNEC and a random weighted sample of patients with SCC and ADC. We used competing-risks regression analysis to evaluate the association between histological type and cancer-specific survival and mortality. Results: Of all 2,108 patients, 1,632 (77.4%) had SCC, 346 (16.4%) had ADC and 130 (6.2%) had SNEC. Overall, five-year cancer-specific survival was 60.0%, 54.7%, and 48.4% in patients with SCC, ADC and SNEC, respectively. After adjusting for other clinical and pathological factors, patients with SNEC and ADC had higher risk of cancer-related death compared with SCC patients (hazard ratio [HR] 2.6; 95% CI, 1.9-3.5 and HR 1.3; 95% CI, 1.1-1.5, respectively). Patients with SNEC were younger and had higher risk of cancer-related death in both early and advanced stages compared with SCC patients (HR 4.9; 95% CI, 2.7-9.1 and HR 2.5; 95% CI, 1.7-3.5, respectively). Those with advanced-stage ADC had a greater risk of cancer-related death (HR 1.4; 95% CI, 1.2-1.7) compared with those with advanced-stage SCC, while no significant difference was observed in patients with early stage lesions. Conclusion: Histological type is an important prognostic factor among patients with cervical cancer in Thailand. Though patients with SNEC were younger and more often had a diagnosis of early stage compared with ADC and SCC, SNEC was associated with poorest survival. ADC was associated with poorer survival compared with SCC in advanced stages, while no difference was observed at early stages. Further tailored treatment-strategies and follow-up planning among patients with different histological types should be considered.

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“…The most important and widely studied prognostic variables for cervical cancer are lymph node spread, tumor size, involvement of parametrial tissue, depth of invasion, and lymphovascular invasion. [3][4][5][6] The incidence of patients with lymph node involvement increased with parametrial extension (P < .01). The corrected 5-year survival rates were 94% for patients with stage IB disease, 95% for patients with stage IIA disease, and 78% for patients with stage IIB disease.…”

mentioning

confidence: 99%

“…4 Similarly, it was reported that lymph node status, parametrial invasion, lymphovascular space invasion, and a histology of pure adenocarcinoma were important histopathologic prognostic factors for patients with early-stage cervical carcinoma who underwent radical surgery. 5 Although lymphovascular invasion does not alter FIGO staging, if the lymphovascular invasion is >3 mm and < 5 mm, then the risk of recurrence is 15.7% compared with a risk of only 3.1% if the invasion is < 3 mm. 6 Positron emission tomography (PET) is an in vivo, functional imaging modality that depends on the metabolic behavior of the viable cells.…”

mentioning

confidence: 99%

¹⁸F‐fluoro‐2‐deoxy‐D‐glucose–positron emission tomography (PET)/PET‐computed tomography in carcinoma of the cervix

Kumar

Dadparvar

2007

Cancer

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Lentivirus‐derived vectors (LVs) were studied for the generation of stable recombinant Chinese hamster ovary (CHO) cell lines. Stable pools and clones expressing the enhanced green fluorescent protein (eGFP) were selected via fluorescence‐activated cell sorting (FACS). For comparison, cell pools and cell lines were also generated by transfection, using the LV transfer plasmid alone. The level and stability of eGFP expression was greater in LV‐transduced cell lines and pools than in those established by transfection. CHO cells were also infected at two different multiplicities of infection with an LV co‐expressing eGFP and a tumor necrosis factor receptor:Fc fusion protein (TNFR:Fc). At 2‐day post‐infection, clonal cell lines with high eGFP‐specific fluorescence were recovered by FACS. These clones co‐expressed TNFR:Fc with yields of 50–250 mg/L in 4‐day cultures. The recovered cell lines maintained stable expression over 3 months in serum‐free suspension culture without selection. In conclusion, LV‐mediated gene transfer provided an efficient alternative to plasmid transfection for the generation of stable and high‐producing recombinant cell lines. Biotechnol. Bioeng. 2011; 108:600–610. © 2010 Wiley Periodicals, Inc.

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Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomy

Cited by 175 publications

References 25 publications

Prognostic Model in Patients with Early-stage Squamous Cell Carcinoma of the Uterine Cervix: A Combination of Invasive Margin Pathological Characteristics and Lymphovascular Space Invasion

Prognostic Model in Patients with Early-stage Squamous Cell Carcinoma of the Uterine Cervix: A Combination of Invasive Margin Pathological Characteristics and Lymphovascular Space Invasion

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

¹⁸F‐fluoro‐2‐deoxy‐D‐glucose–positron emission tomography (PET)/PET‐computed tomography in carcinoma of the cervix

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Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systematic retroperitoneal lymphadenectomy

Cited by 175 publications

References 25 publications

Prognostic Model in Patients with Early-stage Squamous Cell Carcinoma of the Uterine Cervix: A Combination of Invasive Margin Pathological Characteristics and Lymphovascular Space Invasion

Prognostic Model in Patients with Early-stage Squamous Cell Carcinoma of the Uterine Cervix: A Combination of Invasive Margin Pathological Characteristics and Lymphovascular Space Invasion

Prognostic Impact of Histology in Patients with Cervical Squamous Cell Carcinoma, Adenocarcinoma and Small Cell Neuroendocrine Carcinoma

18F‐fluoro‐2‐deoxy‐D‐glucose–positron emission tomography (PET)/PET‐computed tomography in carcinoma of the cervix

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¹⁸F‐fluoro‐2‐deoxy‐D‐glucose–positron emission tomography (PET)/PET‐computed tomography in carcinoma of the cervix