This research focuses on examining the influence of financial ratios using several variables (net profit margin, return on equity, debt to equity ratio, current ratio, price to book value, total asset turnover), firm size and operating cash flow to stock return through mediation earning per share in manufacturing companies. This research uses the financial statements of manufacturing companies for 7 years (2008)(2009)(2010)(2011)(2012)(2013)(2014) with purposive sampling method and obtained 38 samples of manufacturing companies. This research is classified as a quantitative research with analytical method used is path analysis. The results of this research indicate that net profit margin, total asset turnover, debt to equity ratio, and firm size directly affect the variable earnings per share. While the results of path analysis explained that earnings per share indirectly mediate the relationship between net profit margin, total asset turnover, debt equity ratio, and firm size to stock return variables.