Multivalent Targeting of the Asialoglycoprotein Receptor by Virus‐Like Particles
Robert Hincapie,
Sonia Bhattacharya,
Michael M. Baksh
et al.
Abstract:The asialoglycoprotein receptor (ASGPR) is expressed in high density on hepatocytes. Multivalent variants of galactosyl carbohydrates bind ASGPR with high affinity, enabling hepatic delivery of ligand‐bound cargo. Virus‐like particle (VLP) conjugates of a relatively high‐affinity ligand were efficiently endocytosed by ASGPR‐expressing cells in a manner strongly dependent on the nature and density of ligand display, with the best formulation using a nanomolar‐, but not a picomolar‐level, binder. Optimized parti… Show more
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