Multivalent mesoporous silica nanoparticles photo-delivering nitric oxide with carbon dots as fluorescence reporters

Afonso, Damien; Valetti, Sabrina; Fraix, Aurore; Bascetta, Claudia; Petralia, Salvatore; Conoci, Sabrina; Feiler, Adam; Sortino, Salvatore

doi:10.1039/c7nr04832g

Cited by 35 publications

(16 citation statements)

References 41 publications

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“…10 nm blue-shifted if compared to that observed for the free NOPD in aqueous medium (see spectrum in Scheme 1, for sake of comparison), probably as a result of the different environment experienced by this chromogenic unit into the pore of the silica scaffold. This finding is in excellent agreement to what we recently observed for the same NOPD anchored on similar MSNs [36]. Note that, the introduction of the NOPD functionality into the nanoscaffold did not affect the particles size whose diameter was still of ~100 nm.…”

Section: Resultssupporting

confidence: 92%

“…Mesoporous silica nanoparticles (MSNs) are very suitable scaffolds to this end due to their high loading capacity, ease of surface functionalization, good biocompatibility, and satisfactory light transparency [26,27,28,29,30]. Moreover these inorganic scaffolds have been extensively used as excellent carrier for (i) conventional chemotherapeutics to reverse MDR [31], (ii) PDT agents alone and in combinations with chemotherapeutics [32,33,34], and (iii) spontaneous NO donors [35] and NOPD [36].…”

Section: Introductionmentioning

confidence: 99%

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“Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy

et al. 2019

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This contribution reports the design, preparation, photophysical and photochemical characterization, as well as a preliminary biological evaluation of mesoporous silica nanoparticles (MSNs) covalently integrating a nitric oxide (NO) photodonor (NOPD) and a singlet oxygen (1O2) photosensitizer (PS) and encapsulating the anticancer doxorubicin (DOX) in a noncovalent fashion. These MSNs bind the NOPD mainly in their inner part and the PS in their outer part in order to judiciously exploit the different diffusion radius of the cytotoxic NO and 1O2. Furthermore this silica nanoconstruct has been devised in such a way to permit the selective excitation of the NOPD and the PS with light sources of different energy in the visible window. We demonstrate that the individual photochemical performances of the photoactive components of the MSNs are not mutually affected, and remain unaltered even in the presence of DOX. As a result, the complete nanoconstruct is able to deliver NO and 1O2 under blue and green light, respectively, and to release DOX under physiological conditions. Preliminary biological results performed using A375 cancer cells show a good tolerability of the functionalized MSNs in the dark and a potentiated activity of DOX upon irradiation, due to the effect of the NO photoreleased.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

“Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy

et al. 2019

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“…Schoenfisch and coworkers [102], among others [103], have used silica nanoparticles as a delivery method for NO-releasing compounds. Several recent studies (29,104,105) have demonstrated the use of similar silica-based NPs for photoNORM and photoCORM delivery agents. As will be discussed in the next section, Garcia et al (29) prepared mesoporous silica NPs with a NIR-photoactive core consisting of a upconverting NP (UCNP Figure 6.…”

Section: Polymer Metallic and Other Nanomaterials Platformsmentioning

confidence: 99%

Metal complex strategies for photo-uncaging the small molecule bioregulators nitric oxide and carbon monoxide

Ford

2018

Coordination Chemistry Reviews

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Photochemical release (uncaging) of small molecule bioregulators (SMBs) such as nitric oxide (NO) or carbon monoxide (CO) at physiological sites offers exquisite control of timing, location and dosage. However, photo-uncaging faces two major problems that challenge its therapeutic applications: the relatively poor transmision of visible light through tissue and the need to deliver the appropriate precursors to the desired targets. In this brief review are discussed research activitites that address these issues of spatial-temporal control. Contents:1. Introduction 2. Key issues in photo-uncaging 3. Nitric oxide and carbon monoxide precursors.3.1 PhotoNORMs 3.2 PhotoCORMs 4. Two-photon excitation 5. Quantum dots platforms. 6. Polymer, metallic and other nanomaterial platforms. 7. Upconverting nanoparticles as antennas 8. Biological targeting 9. Summary and perspective 10. Abbreviations 11. Acknowledgements 12. Appendix: Discussion of "first order rate laws" in photochemical reactions. 13. References

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“…However, their use is often limited because of reduced water solubility, photostability, prolonged cutaneous photosensitivity, and low selectivity [ 104 ]. For this region, different approaches have been investigated to combine photosensitizing drugs with other carriers such as liposomes [ 105 ], polymer nanoparticles [ 106 , 107 ], gold nanoparticles [ 108 ], carbon nanotubes [ 109 ], graphene’s [ 110 , 111 ] and carbon nanoparticles [ 112 , 113 ]. Recently, Huang et al [ 114 ] prepared a novel theranostic system based on chlorin e6-conjugated C-dots (C-dots-Ce6).…”

Section: Cds For Cancer Therapymentioning

confidence: 99%

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

Nocito

Calabrese

Forte³

et al. 2021

Cancers

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Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy.

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Multivalent mesoporous silica nanoparticles photo-delivering nitric oxide with carbon dots as fluorescence reporters

Cited by 35 publications

References 41 publications

“Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy

“Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy

Metal complex strategies for photo-uncaging the small molecule bioregulators nitric oxide and carbon monoxide

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

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