Multivalent cations-triggered rapid shape memory sodium carboxymethyl cellulose/polyacrylamide hydrogels with tunable mechanical strength

Li, Nan; Chen, Guangxue; Chen, Wei; Huang, Jiahe; Tian, Junfei; Wan, Xiaofang; He, Mengchang; Zhang, Hongfang

doi:10.1016/j.carbpol.2017.09.030

Cited by 75 publications

(33 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By comparing the XRD patterns of the Ag NPs and Ag‐PEGMA, it is indicated that the modification of Ag NPs by PEGMA through the linker did not change the crystal structure and crystallinity of Ag NPs. However, as revealed, the strong broad peaks at 2 θ value of 36° (101) and 56° (110) are disappeared in the PPO/PEO‐C @Ag hybrid nanocomposite hydrogels due to noncovalent interactions among Ag NPs and PPO/PEO‐C matrix 57 . We calculated interspacing (d‐spacing) value of the PPO/PEO‐C composite hydrogels to be 0.43 nm, while the obtained value changed slightly with the introduction of PPO/PEO polymer chain (0.28 nm for PPO/PEO‐C @Ag hybrid nanocomposite hydrogels), indicating the additional interactions that are established between the cellulose molecules, PPO/PEO and the Ag NPs incorporated in the PPO/PEO‐C@Ag hybrid nanocomposite hydrogels.…”

Section: Resultsmentioning

confidence: 92%

“…However, as revealed, the strong broad peaks at 2θ value of 36 (101) and 56 (110) are disappeared in the PPO/PEO-C @Ag hybrid nanocomposite hydrogels due to noncovalent interactions among Ag NPs and PPO/PEO-C matrix. 57 We calculated interspacing (d-spacing) value of the PPO/PEO-C composite hydrogels to be 0.43 nm, while the obtained value changed slightly with the introduction of PPO/PEO polymer chain (0.28 nm for PPO/PEO-C @Ag hybrid nanocomposite hydrogels), indicating the additional interactions that are established between the cellulose molecules, PPO/PEO and the Ag NPs incorporated in the PPO/PEO-C@Ag hybrid nanocomposite hydrogels. The crystallite size of Ag 0 nanoparticles embedded in the hydrogel matrix is estimated 21.54 nm by using Debye-Scherrer equation.…”

Section: Xrd Analysismentioning

confidence: 85%

See 1 more Smart Citation

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

This article deals with the synthesis of hybrid nanocomposite hydrogels through the combination of cellulose (C), polypropylene oxide/poly ethylene oxide (PPO/PEO), and silver nanoparticles (AgNPs) by in situ polymerization technique for the in vitro release of ornidazole drugs. The structure of the resulted materials is identified using SEM, XRD, FTIR, XPS, and TGA spectroscopic techniques. The resulting structure, morphology, thermo responsive property, water retention, and swelling behavior of hydrogels are investigated. The rheological measurement is studied to establish the enhancement of the viscoelasticity and stiffness of hydrogels. The antibacterial activity of the biodegradable silver hybrid nanocomposite hydrogel is investigated by inhibition zone method against gram positive and negative bacteria. Maximum drug release of 96.4% is recorded at 7.4 pH in 5 h. The biocompatibility and cytotoxicity of the hybrid nanocomposite hydrogel are verified using mouse fibroblast cell line L-929 (ATCC CCL-1) cells for their possible use as controlled drug delivery vehicles. The nontoxic nature makes the materials more biocompatible and suitable to apply in the biological systems. Therefore, nontoxic and biocompatible natures of present materials with improved thermal and rheological properties support for their possible uses as drug delivery vehicles.

show abstract

Section: Resultsmentioning

confidence: 92%

Section: Xrd Analysismentioning

confidence: 85%

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Prusty

Swain

2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Sodium carboxymethyl cellulose (CMC), a representative cellulose derivative, is a polymer with multiple carboxyl groups and excellent water-solubility. 28,29 At present, various types of CMC-based hydrogels have been applied for drugs delivery, enzyme immobilization, and tissue engineering due to their low toxicity, biocompatibility, and economic advantages. 30,31 Considerable works on CMC-based hydrogel systems for drugs delivery have been published.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of a novel semi-interpenetrating network hydrogel based on sodium carboxymethyl cellulose and poly(methacrylic acid) for oral insulin delivery

Chen

Wang

et al. 2020

J Biomater Appl

View full text Add to dashboard Cite

In this research, pH-sensitive semi-interpenetrating polymer network hydrogels based on sodium carboxymethyl cellulose and poly(methacrylic acid) were synthesized using free radical polymerization and semi-interpenetrating polymer network approach for oral administration of insulin. The chemical structure and thermal stability of the hydrogels were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis measurements. The interior morphology was observed by scanning electron microscopy and the inner structure exhibited a porous honeycomb-like shape. The investigations on the swelling properties of hydrogels revealed their ability to response to pH value change. The in vitro release behavior of insulin was pH dependent and the release of insulin was much lower at pH 1.2 compared to pH 6.8. In vitro cytotoxicity assay indicated that the hydrogels were noncytotoxic to HeLa cells. A sustained reduction in blood glucose level was observed after oral administration of insulin-loaded hydrogel to diabetic rats at 75 IU/kg. These results indicated that the hydrogel would be a promising vehicle for oral insulin delivery systems.

show abstract

“…9 Shape memory effect (SME) can be achieved by reversibly changing the weak network for shape xation and recovery. 10 Therefore, stimuli responsive weak reversible cross-linking bonds have been introduced to endow hydrogels with shape memory properties, including dynamic covalent bonds, 11 crystallization, 12 metal-ligand coordination, 13 hydrogen-bonding, 14 peptide and protein self-assembly, 15 host-guest interactions, 16 etc.…”

Section: Introductionmentioning

confidence: 99%

Thermal- and salt-activated shape memory hydrogels based on a gelatin/polyacrylamide double network

et al. 2019

View full text Add to dashboard Cite

show abstract

Multivalent cations-triggered rapid shape memory sodium carboxymethyl cellulose/polyacrylamide hydrogels with tunable mechanical strength

Cited by 75 publications

References 41 publications

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Polypropylene oxide/polyethylene oxide‐cellulose hybrid nanocomposite hydrogels as drug delivery vehicle

Fabrication and characterization of a novel semi-interpenetrating network hydrogel based on sodium carboxymethyl cellulose and poly(methacrylic acid) for oral insulin delivery

Thermal- and salt-activated shape memory hydrogels based on a gelatin/polyacrylamide double network

Contact Info

Product

Resources

About