Multitracer techniques: applications in chemical and life sciences

Nayak, Dalia

doi:10.1016/s0969-8043(00)00195-0

Cited by 9 publications

(1 citation statement)

References 34 publications

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“…This technique uses a large number of radioactive tracers produced from a metal target, such as Ag or Au foil, irradiated with high-energy heavy ions, which enables the simultaneous evaluation of behavior for a large number of elements under identical conditions. The technique has been applied successfully in various fields and has been shown to be effective in studying the metabolism of trace elements in biological systems (Ambe et al 1995;Ambe 1996;Enomoto & Hirunuma 2001;Nayak 2001). Using the multitracer technique, Gouthu et al studied the subcellular distribution of trace elements in soybean (Glycine max Merr.)…”

Section: Introductionmentioning

confidence: 99%

Multitracer Screening: Brain Delivery of Trace Elements by Eight Different Administration Methods

et al. 2005

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Trace elements are closely associated with the normal functioning of the brain. Therefore, it is important to determine how trace elements enter, accumulate, and are retained in the brain. Using the multitracer technique, which allows simultaneous tracing of many elements and comparison of their behavior under identical experimental conditions, we examined the influence of different administration methods, i.e., intravenous (IV), intraperitoneal (IP), intramuscular (IM), subcutaneous (SC), intracutaneous (IC), intranasal (IN), peroral (PO), and percutaneous (PC) administration, on the uptake of trace elements. A multitracer solution containing 16 radionuclides (i.e., 7Be, 46Sc, 48V, 51Cr, 54Mn, 59Fe, 56Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, 88Y, 88Zr, 95mTc, and 103Ru) was used. The results indicated that the 83Rb brain uptake rate with intranasal administration was approximately twice those obtained with the other administration methods. This result indicated that a portion of Rb was delivered into the brain circumventing the blood circulation and that delivery could be accomplished mainly by olfactory transport. Multitracer screening of trace element delivery revealed differences in brain uptake pathways among administration methods.

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Section: Introductionmentioning

confidence: 99%