Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium <i>Staphylococcus aureus</i>: A Proteomic Characterization

Elmasri, Wael A.; Zhu, Rui; Peng, Wenjing; Al‐Hariri, Moustafa; Kobeissy, Firas; Tran, Phat L.; Hamood, Abdul N.; Hegazy, Mohamed‐Elamir F.; Paré, Paul W.; Mechref, Yehia

doi:10.1021/acs.jproteome.7b00137

Cited by 35 publications

(32 citation statements)

References 48 publications

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“…5,6). Elmasri et al (2017) reported 5,6,7,4 0 ,5 0pentahydroxyflavone (3) and 5-hydroxy-4 0 ,7dimethoxyflavone (5) to downregulate the malonyl CoA-acyl carrier protein transacylase fabD (MCATs) that regulates bacterial FAS-II. Thus, these two flavones are considered to be the promising drugs for blocking the bacterial growth.…”

Section: Inhibition Of Cell Envelope Synthesismentioning

confidence: 99%

“…A decline in the overall bacterial metabolism can lead to the indirect arrest of the biofilm formation, as well. Notably, the 4 0 ,5 0 ,5-trihydroxy-6,7-dimethoxyflavone (8) (from Teucrium polium) was reported to affect the F-type ATP synthase (atpD) and thus reduce the ATP availability in S. aureus (Elmasri et al 2017).…”

Section: Inhibition Of Electron Transport Chain and Atp Synthesismentioning

confidence: 99%

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Comprehensive review of antimicrobial activities of plant flavonoids

2018

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Flavonoids are one of the largest classes of small molecular secondary metabolites produced in different parts of the plant. They display a wide range of pharmacological and beneficial health effects for humans, which include, among others, antioxidative activity, free radical scavenging capacity, coronary heart disease prevention and antiatherosclerotic, hepatoprotective, anti-inflammatory, and anticancer activities. Hence, flavonoids are gaining high attention from the pharmaceutical and healthcare industries. Notably, plants synthesize flavonoids in response to microbial infection, and these compounds have been found to be a potent antimicrobial agent against a wide range of pathogenic microorganisms in vitro. Antimicrobial action of flavonoids results from their various biological activities, which may not seem very specific at first. There are, however, promising antibacterial flavonoids that are able not only to selectively target bacterial cells, but also to inhibit virulence factors, as well as other forms of microbial threats, e.g. biofilm formation. Moreover, some plant flavonoids manifest ability to reverse the antibiotic resistance and enhance action of the current antibiotic drugs. Hence, the development and application of flavonoid-based drugs could be a promising approach for antibiotic-resistant infections. This review aims to improve our understanding of the biological and molecular roles of plant flavonoids, focusing mostly on their antimicrobial activities.

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Section: Inhibition Of Cell Envelope Synthesismentioning

confidence: 99%

Section: Inhibition Of Electron Transport Chain and Atp Synthesismentioning

confidence: 99%

Comprehensive review of antimicrobial activities of plant flavonoids

2018

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“…Further, naringenin (3) and taxifolin (38) (Figure 2) inhibit 3-ketoacyl-ACP synthase from E. faecalis [139]. Flavonoids such as Epigallocatechin gallate (EGCG) (20), 5, 6, 7, 40, 50-pentahydroxyflavone (39), and 5-hydroxy-40, 7-dimethoxyflavone (40) inhibit the malonyl CoA-acyl carrier protein transacylase that regulates bacterial FAS-II [140,141]. EGCG (20) inhibits 3-ketoacyl-ACP reductase and enoyl-ACP reductase and prevents fatty acid biosynthesis [142].…”

Section: Inhibition Of Cell Wall Constructionmentioning

confidence: 99%

“…It has been described that flavonoids such as baicalein (44), morin (9), silibinin (57), quercetin (1), isoquercetin (58), quercitrin (59), and silymarin (60) can constrain the F1FO ATPase system of E. coli and result in the obstruction of ATP synthesis [157][158][159]. Additionally, EGCG (20), 40, 50, 5-trihydroxy-6, 7-dimethoxy-flavone (61), and proanthocyanidins (27) have also inhibited S. mutans, P. aeruginosa and S. aureus through the enzymatic activity of F1FO ATPase respectively [100,104,141].…”

Section: Inhibition Of Energy Productionmentioning

confidence: 99%

Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

Mickymaray

2019

Antibiotics

110

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Traditional medicinal plants have been cultivated to treat various human illnesses and avert numerous infectious diseases. They display an extensive range of beneﬁcial pharmacological and health effects for humans. These plants generally synthesize a diverse range of bioactive compounds which have been established to be potent antimicrobial agents against a wide range of pathogenic organisms. Various research studies have demonstrated the antimicrobial activity of traditional plants scientifically or experimentally measured with reports on pathogenic microorganisms resistant to antimicrobials. The antimicrobial activity of medicinal plants or their bioactive compounds arising from several functional activities may be capable of inhibiting virulence factors as well as targeting microbial cells. Some bioactive compounds derived from traditional plants manifest the ability to reverse antibiotic resistance and improve synergetic action with current antibiotic agents. Therefore, the advancement of bioactive-based pharmacological agents can be an auspicious method for treating antibiotic-resistant infections. This review considers the functional and molecular roles of medicinal plants and their bioactive compounds, focusing typically on their antimicrobial activities against clinically important pathogens.

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“…ROS alter the bacterial membrane permeability [94]. Additionally, the bacterial fatty acid synthases (FAS) are regulated by flavonoids via an acyl carrier protein transacylases responsible for the synthesis of phospholipid components [95].…”

Section: Effects On the Bacterial And Fungal Membranementioning

confidence: 99%

Plant Fibers and Phenolics: A Review on Their Synthesis, Analysis and Combined Use for Biomaterials with New Properties

Berni

Cai

Hausman

et al. 2019

Fibers

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Devising environmental-friendly processes in biotechnology is a priority in the current economic scenario. We are witnessing a constant and steady push towards finding sustainable solutions to societal challenges by promoting innovation-driven activities minimizing the environmental impact and valorizing natural resources. In bioeconomy, plants are among the most important renewable sources of both fibers (woody and cellulosic) and phytochemicals, which find applications in many industrial sectors, spanning from the textile, to the biocomposite, medical, nutraceutical, and pharma sectors. Given the key role of plants as natural sources of (macro)molecules, we here provide a compendium on the use of plant fibers functionalized/impregnated with phytochemicals (in particular phenolic extracts). The goal is to review the various applications of natural fibers functionalized with plant phenolics and to valorize those plants that are source of both fibers and phytochemicals.Fibers 2019, 7, 80 2 of 17 secreting enzymes acting on cell wall polysaccharides [7] (e.g., pectinases degrading the middle lamellas which "glue" together the bundles of bast fibers).Fibers 2019, 7, x FOR PEER REVIEW 2 of 17 (fungi, such as Ascomycota, Basidiomycota, and Zygomycota and bacteria belonging to the phyla Proteobacteria, Bacteroidetes, Actinobacteria, and Firmicutes [6]) secreting enzymes acting on cell wall polysaccharides [7] (e.g., pectinases degrading the middle lamellas which "glue" together the bundles of bast fibers). Figure 1. Cross section of the stem of a representative fiber crop, stinging nettle (Urtica dioica L.), and details of enzyme-treated cortical peels with some separated bast fibers. (a) Transversal cross section stained with Safranin and Alcian blue (FASGA staining), showing in blue the cellulosic bast fibers and in red lignin; (b) cortical peels separated from the stem bottom internodes and treated for 24 h at 50 °C with TEXAZYM BFE (INOTEX Ltd, Czech Republic) showing some separated bast fibers; the inset shows one separated bast fiber.The use of plant fibers provides several advantages, namely breathability and comfort in case of skin irritations/allergies [8]. Adding to them anti-microbial and anti-oxidant effects greatly widens their spectrum of applications to, for example, the manufacture of technical textiles, such as those used for wound healing. Notably, plants are also rich sources of phytochemicals showing antioxidant and bactericidal/fungicidal effects. Some plant species, such as the fiber crops hemp and nettle, are multi-purpose, as they produce both high yields of cellulosic fibers and phytochemicals [2,9].In this review we will illustrate recent examples of natural fibers functionalized (i.e., with a chemical bond) or impregnated with phytochemicals (more specifically phenolics which show strong antimicrobial activities thanks to their chemical heterogeneity [10]). The goal is to highlight the value of plants as renewable resources of biomass (fibers) on one hand and of molecules with biological effe...

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Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization

Cited by 35 publications

References 48 publications

Comprehensive review of antimicrobial activities of plant flavonoids

Comprehensive review of antimicrobial activities of plant flavonoids

Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens

Plant Fibers and Phenolics: A Review on Their Synthesis, Analysis and Combined Use for Biomaterials with New Properties

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