Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond

Pappalardo, Federico; Malara, Giulia; Montisci, Andrea

doi:10.3390/membranes11020087

Cited by 2 publications

(1 citation statement)

References 48 publications

(54 reference statements)

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“…Ischaemic heart disease is a huge public health problem, with an increasing incidence and almost 1.8 million deaths every year (Pappalardo et al, 2021). Acute myocardial infarction (AMI), as a typical ischaemic heart disease, is the primary event of myocardial ischaemic necrosis caused by a long period of ischaemia (Anderson et al, 2017;Pappalardo & Malara, 2021). Prolonged ischaemia or hypoxia leads to cardiomyocyte death (> 1 billion human cardiomyocytes) followed by © 2021 The Authors.…”

Section: Introductionmentioning

confidence: 99%

LncRNA MIAT promotes hypoxia‐induced H9C2 cell pyroptosis via binding to SF1 to inhibit CGRP transcription

Zhou

2021

Experimental Physiology

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Hypoxia induces severe cardiomyocyte pyroptosis, contributing to acute myocardial infarction. The aim of this study was to analyse the molecular mechanism of long noncoding RNA myocardial infarction-associated transcript (lncRNA MIAT) in hypoxiainduced H9C2 cell pyroptosis. A hypoxic H9C2 cell model was established. Cell viability was detected via the Cell Counting Kit-8 method. Levels of lactate dehydrogenase, malondialdehyde and superoxide dismutase and expressions of pyroptotic markers, lncRNA MIAT, splicing factor 1 (SF1) and calcitonin gene-related peptide (CGRP) were detected via qRT-PCR. The subcellular localization of lncRNA MIAT was predicted and confirmed via LncATLAS and nuclear/cytosol fractionation assay. The binding relationships between lncRNA MIAT and SF1 and between SF1 and the CGRP promotor were verified via RNA immunoprecipitation. Rescue experiments were designed to confirm the role of lncRNA MIAT/SF1/CGRP in H9C2 cell pyroptosis. LncRNA MIAT was overexpressed in hypoxia-induced H9C2 cells. Hypoxia induced pyroptosis in H9C2 cells. Silencing of lncRNA MIAT enhanced cell viability and alleviated pyroptosis. LncRNA MIAT inhibited CGRP transcription via binding to SF1. Overexpression of SF1 promoted CGRP transcription and relieved H9C2 cell pyroptosis. Downregulation of CGRP reversed the role of silencing lncRNA MIAT in H9C2 cell pyroptosis. Overall, lncRNA MIAT inhibited CGRP transcription via binding to SF1, thereby promoting hypoxia-induced H9C2 cell pyroptosis.

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Section: Introductionmentioning

confidence: 99%

LncRNA MIAT promotes hypoxia‐induced H9C2 cell pyroptosis via binding to SF1 to inhibit CGRP transcription

Zhou

2021

Experimental Physiology

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Statement of Removal: Functional analysis of ceRNA network of lncRNA TSIX/miR-34a-5p/RBP2 in acute myocardial infarction based on GEO database

et al. 2021

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Jiezhong Lin, Jianyi Zhou, Guiting Xie, Xiongwei Xie, Yanfang Luo and Jinguang Liu. Functional analysis of ceRNA network of lncRNA TSIX/miR-34a-5p/RBP2 in acute myocardial infarction based on GEO database. 2021 Oct. doi: 10.1080/21655979.2021.2006865. Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article. When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record’s integrity, we are retracting the article. All authors listed in this publication have been informed. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted.’

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Multitarget Approach to Cardiogenic Shock after Acute Myocardial Infarction: Extracorporeal Life Support (ECLS) and Beyond

Cited by 2 publications

References 48 publications

LncRNA MIAT promotes hypoxia‐induced H9C2 cell pyroptosis via binding to SF1 to inhibit CGRP transcription

LncRNA MIAT promotes hypoxia‐induced H9C2 cell pyroptosis via binding to SF1 to inhibit CGRP transcription

Statement of Removal: Functional analysis of ceRNA network of lncRNA TSIX/miR-34a-5p/RBP2 in acute myocardial infarction based on GEO database

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