Multisystemic therapy versus management as usual in the treatment of adolescent antisocial behaviour (START): 5-year follow-up of a pragmatic, randomised, controlled, superiority trial

Fonagy, Peter; Butler, Stephen; Cottrell, David; Scott, Stephen; Pilling, Stephen; Eisler, Ivan; Fuggle, Peter; Kraam, Abdullah; Byford, Sarah; Wason, James; Smith, Jonathan A.; Anokhina, Alisa; Ellison, Rachel; Simes, Elizabeth; Ganguli, Poushali; Allison, Elizabeth; Goodyer, Ian

doi:10.1016/s2215-0366(20)30131-0

Cited by 21 publications

(15 citation statements)

References 23 publications

(21 reference statements)

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“…START data can be accessed through the procedure described in Fonagy et al . (2020). PREVAIL data were derived from the NCBI website (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118657) (Maslove and Muscedere, 2018).…”

Section: Data Availability Statementmentioning

confidence: 99%

Two‐stage penalized regression screening to detect biomarker–treatment interactions in randomized clinical trials

et al. 2021

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High-dimensional biomarkers such as genomics are increasingly being measured in randomized clinical trials. Consequently, there is a growing interest in developing methods that improve the power to detect biomarker-treatment interactions. We adapt recently proposed two-stage interaction detecting procedures in the setting of randomized clinical trials. We also propose a new stage 1 multivariate screening strategy using ridge regression to account for correlations among biomarkers. For this multivariate screening, we prove the asymptotic between-stage independence, required for familywise error rate control, under biomarker-treatment independence. Simulation results show that in various scenarios, the ridge regression screening procedure can provide substantially greater power than the traditional one-biomarker-at-a-time screening procedure in highly correlated data. We also exemplify our approach in two real clinical trial data applications.

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Section: Data Availability Statementmentioning

confidence: 99%

Two‐stage penalized regression screening to detect biomarker–treatment interactions in randomized clinical trials

et al. 2021

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“…Another solution is Parent Training and Multi-systemic Therapy. Multi-systemic therapy is a treatment based on evidence designed for youth with serious antisocial behavior and high risk for out of home and their families (Fonagy et al, 2020;Henggeler & Schaeffer, 2016;Rogers & Broome, 2020). The programme is intensive and family focused and helps young people manage their behaviour in various contexts, including at home, at school, and in the community (Fonagy et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Multi-systemic therapy is a treatment based on evidence designed for youth with serious antisocial behavior and high risk for out of home and their families (Fonagy et al, 2020;Henggeler & Schaeffer, 2016;Rogers & Broome, 2020). The programme is intensive and family focused and helps young people manage their behaviour in various contexts, including at home, at school, and in the community (Fonagy et al, 2020). Multisystemic therapy is a promising intervention to improve the prognosis of antisocial and offending behaviour in young people (Markham, 2018).…”

Section: Introductionmentioning

confidence: 99%

Training Treatment Skill of Children Abuse Victims for College Students

Koesdyantho¹

2021

IJCSL

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Child abuse is a serious phenomenon that needs treatment to recover the victims. The present article aims at describing a training of giving treatments to recover children as victims from abuse and violence to show the students’ (participants) knowledge and service before they do internship program at an orphanage. The subject of research is 7th semester students of guidance and counseling program at Universitas Slamet Riyadi, Indonesia. The result of the research are the improvements of the college students’ knowledge and service in giving treatment for child abuse victims; they are familiar with six forms of treatment to recover the victims that consist of Combined Parent-Child Cognitive Behavioral Therapy (CPC-CBT), Parent Training and Multi-systemic Therapy, Project Support (Children’s Protective Services), Web-based parenting skills, Home Visiting Program, and School Based Mental Health Intervention for Children. The conclusion of the article is treatments in the form of collaboration between parents (caregivers), schools, and children (as victims) to recover child abuse and violence through a variety of phases to realize the purposes and children abuse as victims need appropriate treatment based on the condition of them and such six treatments as a choice and solution to recover the victims.

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“…they were assigned to MAU). The results from the main trial are published in Fonagy et al (2020a) and a summary report of the whole research programme can be found in Fonagy et al (2020b). We are planning a subsequent paper considering the discrepancies between the results of the different arms of the overall programme.…”

Section: Introductionmentioning

confidence: 99%

The Long-Term Impact of Multisystemic Therapy: An Experiential Study of the Adolescent-Young Adult Life Transition

Conroy

Smith

Butler

et al. 2021

Journal of Adolescent Research

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This qualitative study examines the possible long-term impact of multisystemic therapy (MST) as young people experience the transition from adolescence to young adulthood. MST is an intensive intervention aimed at reducing antisocial behavior among young people. Interviews were conducted with 32 young people aged 16 to 22 years at their 48-month follow-up as part of the Systemic Therapy for At-Risk Teens (START) evaluation trial in the United Kingdom. Sixteen participants had received MST while 16 received management as usual (MAU). Interviews addressed participants’ current life experiences and were analyzed with interpretative phenomenological analysis (IPA). The inductive qualitative analysis data were transformed into numerical data. Interview extracts were coded as either forward-looking and hopeful (“mature”) or static and frustrated (“stuck”). Among males, significantly more mature outcomes were found among participants who had received MST compared with MAU. No differences were seen between the female groups. A detailed qualitative commentary shows how the constructs, mature and stuck, are manifest across the four domains. The findings suggest that working with an MST therapist during adolescence helped young men cultivate more mature, forward-looking viewpoints and life activities 4 years later when transitioning into adulthood. Findings are discussed in relation to relevant theory and practical applications.

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Multisystemic therapy versus management as usual in the treatment of adolescent antisocial behaviour (START): 5-year follow-up of a pragmatic, randomised, controlled, superiority trial

Cited by 21 publications

References 23 publications

Two‐stage penalized regression screening to detect biomarker–treatment interactions in randomized clinical trials

Two‐stage penalized regression screening to detect biomarker–treatment interactions in randomized clinical trials

Training Treatment Skill of Children Abuse Victims for College Students

The Long-Term Impact of Multisystemic Therapy: An Experiential Study of the Adolescent-Young Adult Life Transition

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