Multisystemic manifestations of IgA vasculitis

Du, Lingyao; Wang, Panpan; Liu, Chang; Li, Shaojing; Yue, Shuang; Yang, Yan

doi:10.1007/s10067-020-05166-5

Cited by 35 publications

(39 citation statements)

References 97 publications

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“…Skin eruptions of IgA V are characterized mainly by palpable purpura 5‐8 with a predilection for the lower legs 3,4 . Although skin involvement is the most frequent in IgA V, systemic involvement is observed in 25%–70% of cases 5,9‐11 . Immune complex‐mediated vasculitis is subdivided to LCV with or without deposition of IgA‐containing immune complexes; the latter includes IgM/IgG‐associated LCV.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…IgA V is usually considered as a self‐limited disease with remission within 4‐6 weeks in children, though adult patients require more aggressive treatment 5 . Systemic steroids were administered in 30.8% of IgA V patients as the first‐line treatment 5 . In our study, systemic steroids were administered to more patients with IgA V. According to a previous report, 4 symptoms recur in 24.4% of patients with IgM/IgG V and 35.7% of those with IgA V, and the time from onset to initial remission is significantly longer in IgA V. In the present study, the IgM/IgG V did not recur, and the time from onset to initial remission did not differ between two groups.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and pathological differences between skin‐limited IgM/IgG vasculitis and skin‐limited IgA vasculitis

Kawamura

Mizutani

et al. 2021

J Cutaneous Imm & Allergy

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Objectives Cutaneous IgM/IgG vasculitis (IgM/IgG V) is characterized by leukocytoclastic vasculitis histologically and by IgM‐ or IgG‐ perivascular deposition. However, clinical differences between IgM/IgG V and skin‐limited IgA vasculitis (IgA V) have not been fully clarified. In the present study, we assessed the clinical and histopathological differences between IgM/IgG V and IgA V. Methods We examined 14 patients with IgM/IgG V and 24 patients with skin‐limited IgA V. The cases associated with systemic diseases were excluded. Clinical findings, laboratory data, and histological findings were compared between IgM/IgG V and IgA V groups. Results Livedo lesions appeared more often, and palpable purpura less often in IgM/IgG V. Localization of the lesions was more limited to the lower legs in IgM/IgG V. In laboratory data, there were no statistical differences in peripheral blood cell counts, IgG, IgA, and IgM levels between the two groups. Histopathological findings showed less infiltration of neutrophils, CD8+ T cells, and CD3+ T cells, and nuclear dusts in IgM/IgG V. Systemic steroids were administered significantly less frequently in IgM/IgG V cases, but the recurrence rate did not differ. Conclusions Based on these results, IgM/IgG V may be a clinically and histologically different entity from IgA V. However, further studies are necessary to define the differences between them more clearly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical and pathological differences between skin‐limited IgM/IgG vasculitis and skin‐limited IgA vasculitis

Kawamura

Mizutani

et al. 2021

J Cutaneous Imm & Allergy

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“…IgA vasculitis, formerly known as Henoch-Schönlein purpura, is the most common form of vasculitis involving the small vessels of the joints, kidneys, gastrointestinal tract, and the skin. 204 Although the etiology of IgA vasculitis remains unknown, the disease is characterized by IgA1 immune deposits and neutrophil infiltrates damaging the small vessels. Abnormal glycosylation of the hinge region of IgA1 is suggested to cause aggregation into macromolecular immune complexes.…”

Section: Iga Vasculitismentioning

confidence: 99%

“…Abnormal glycosylation of the hinge region of IgA1 is suggested to cause aggregation into macromolecular immune complexes. 204 FcαRI-mediated cross-linking of neutrophils induces inflammatory processes like ROS production, NET formation, and LTB4 release. As such, it is hypothesized that FcαRI-mediated activation of neutrophils results in vessel damage and leakage of red blood cells into the skin causing typical cutaneous hemorrhages.…”

Section: Iga Vasculitismentioning

confidence: 99%