Multisystem sarcoidosis and carcinoma of the uterine cervix: An unusual association

Alliot, C.; Linares‐Barrios, Mario; Desplechain, C

doi:10.1046/j.1525-1438.2001.011004323.x

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…It has been speculated that there is the release of an antigen, as a consequence of the testicular cancer chemotherapy, which is able to trigger the onset of sarcoidosis in these susceptible individuals 93 . More recently, similar observations have been made in women with cancer of the cervix 85,88,89,105,115,121 and cancer of the uterus 89,93,115 …”

Section: Sarcoidosismentioning

confidence: 84%

“…In addition to hematologic malignancies, sarcoidosis has also been associated with an increased frequency of solid tumors 89,93,115,116 (Table 3 83,115,117–126 ). Similar to sarcoidosis–lymphoma syndrome, an increased incidence of lung cancer has been observed in patients with the chronic active type of sarcoidosis 88,89,93,105,115,122,123 .…”

Section: Sarcoidosismentioning

confidence: 99%

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Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

Cohen¹

2006

Int J Dermatology

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IntroductionThe appearance of certain dermatoses has heralded either the diagnosis of a previously unsuspected malignancy or the detection of cancer recurrence in an oncology patient. 1,2 These associated mucosal and cutaneous conditions are referred to as mucocutaneous paraneoplastic syndromes. 3 In this issue, Zappasodi et al . 4 review some of the mucocutaneous paraneoplastic syndromes that occur in patients with hematologic malignancies. Albeit less commonly, other dermatologic conditions and systemic disorders can also occur in a paraneoplastic setting associated with hematologic malignancies: granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus. Granuloma AnnulareGranuloma annulare is a chronic dermatosis of undetermined etiology. Clinically, the skin lesions present as flesh-colored to red papules and small nodules, which appear either as individual lesions or as an annular arrangement of confluent lesions. Mucin-containing areas of necrobiotic collagen in the dermis are surrounded by palisading granulomas consisting of epithelioid histiocytes, lymphocytes, and multinucleated giant cells.Granuloma annulare can be localized to a specific area of the body or generalized. Perforating and subcutaneous variants of the condition may also occur. Several factors have been described to precipitate the development of granuloma annulare: sunburn, drug eruption, flu-like illness, trauma, insect bites, and acute phlebitis. In addition, granuloma annulare has been observed in patients with potentially associated diseases -particularly diabetes mellitus and thyroid disease, but also drug allergy, hypertension, obesity, arthritis, atopy, sarcoidosis, and human immunodeficiency virus infection. [5][6][7][8][9] Skin lesions of leukemia or lymphoma that histopathologically mimic granuloma annulare have also been described in patients with hematologic malignancies. 10-14 Cancer-associated granuloma annulare has been reported predominantly in patients with hematologic malignancies (most commonly non-Hodgkin's lymphoma and Hodgkin's disease) and, less often, in individuals with solid tumors (Table 1). 5,6,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Relapsing PolychondritisRelapsing polychondritis is a multisystemic disorder characterized by recurrent inflammation and degeneration of cartilaginous tissues -particularly those of the ears, nose, larynx, and trachea. [34][35][36][37] The dermatologic manifestations of relapsing polychondritis are variable and include aphthosis [oral and complex (genital)], nodules (on the extremities), purpura, papules, sterile pustules, superficial phlebitis, livedo reticularis, ulcers (on the extremities), and distal necrosis. 38 The aorta, bone, bronchi, central nervous system, ears, eyes, genitals, heart valves, kidneys, larynx, mouth, nose, and trachea are potential sites of extracutaneous involvement in patients with relapsing polychondritis. 34,38,39 The diagnostic criteria for relapsing polychondritis were initially e...

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Section: Sarcoidosismentioning

confidence: 84%

Section: Sarcoidosismentioning

confidence: 99%

Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

Cohen¹

2006

Int J Dermatology

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“…Trans-bronchial biopsies and liver biopsies showed multiple non-caseating epithelioid granulomas. Her symptoms resolved rapidly with prednisone therapy (Alliot et al 2001).…”

Section: Discussionmentioning

confidence: 95%

A case of sarcoidosis mimicking recurrences of endometrial cancer

Cormio

Leone

Camporeale

et al. 2014

Journal of Obstetrics and Gynaecology

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Sarcoidosis imitating metastatic cervical cancer

Goldstein

Rettenmaier

Sheffer

et al. 2007

Arch Gynecol Obstet

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Sarcoidosis rarely coincides with gynecologic malignancy and thus, may be misdiagnosed as metastatic cancer. We present a 50-year-old patient who was initially treated for cervical carcinoma. She later presented with persistent coughing and mediastinal lymphadenopathy, suspicious for metastatic disease. Following final pathology, a diagnosis of sarcoidosis was made. Sarcoidosis is rarely associated with cervical carcinoma. However, the disease should be considered when metastatic pulmonary disease is suspected in order to avoid excessive or inappropriate treatment.

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Multisystem sarcoidosis and carcinoma of the uterine cervix: An unusual association

Cited by 10 publications

References 6 publications

Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy‐associated mucocutaneous paraneoplastic syndromes

A case of sarcoidosis mimicking recurrences of endometrial cancer

Sarcoidosis imitating metastatic cervical cancer

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