Multisystem Inflammatory Syndrome in Neonates following Maternal SARS-CoV-2 COVID-19 Infection

Lakshminrusimha, Satyan; Hudak, Mark L.; Dimitriades, Victoria R.; Higgins, Rosemary D.

doi:10.1055/a-1682-3075

Cited by 20 publications

(23 citation statements)

References 32 publications

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“…Most infections in neonates and children arise from family clusters [ 60 ], linked to infected adult patients; they often exhibit only milder clinical signs [ 61 ]. Recently, a few case reports of neonates presenting with a multisystem inflammatory syndrome after maternal SARS-CoV-2 infection (MIS-N) were reported [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Vaccines during Pregnancy and Breastfeeding: A Systematic Review of Maternal and Neonatal Outcomes

Rose

Salvatori

Dotta

et al. 2022

Viruses

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PubMed, Cochrane Library, and the Education Resources Information Center (ERIC) were searched up to 27 October 2021. The primary outcome was to estimate how many pregnant and lactating women were reported to be vaccinated and had available maternal and neonatal outcomes. (3) Results: Forty-five studies sourcing data of 74,908 pregnant women and 5098 lactating women who received COVID-19 vaccination were considered as eligible. No major side-effects were reported, especially during the second and third trimester of pregnancy and during breastfeeding. Conversely, available studies revealed that infants received specific SARS-CoV-2 antibodies after maternal vaccination. (4) Conclusion: Vaccination against the SARS-CoV-2 virus should be recommended for pregnant women, after the pros and cons have been adequately explained. In particular, given the still limited evidence and considering that fever during the first months of gestation increases the possibility of congenital anomalies, they should be carefully counseled. The same considerations apply to breastfeeding women, also considering the immune responses that mRNA vaccines can generate in their human milk.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Vaccines during Pregnancy and Breastfeeding: A Systematic Review of Maternal and Neonatal Outcomes

Rose

Salvatori

Dotta

et al. 2022

Viruses

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“…Recently, there have been reports of multisystem involvement following SARS-COV-2 infection in neonates; however, the extent of involvement, assessment, and their management has varied. Of note, multisystem inflammatory syndrome in neonates (MIS-N) takes various forms with multiple cardiac presentations and complications, and the reported therapies include various immunological treatments [ 4 , 5 , 6 ]. MIS-N is postulated to develop because of immune-mediated multisystem injury either due to the transplacental transfer of maternal SARS-Co2 antibodies or due to late response to antibodies mounted by the newborn to SARS-CoV-2 infection [ 4 , 5 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review

Shaiba

Hadid

et al. 2022

Neonatology

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Introduction: Multisystem inflammatory syndrome in neonates (MIS-N) related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increasingly been reported worldwide amid the spread of the SARS-CoV-2 pandemic. Methods: We searched PubMed, EMBASE, and CINAHL and preprint servers (BioRxiv.org and MedRxiv.org) using a specified strategy integrating Medical Subject Headings terms and keywords until October 20, 2021. Our aim was to systematically review demographic profiles, clinical features, laboratory parameters, complications, treatments, and outcomes of neonates with MIS-N. Studies were selected when fulfilling the inclusion criteria. Articles were included if they fulfilled the World Health Organization (WHO), Centers for Disease Control (CDC) definitions of MIS-C, or our proposed definition. Results: Sixteen reports of MIS-N including 47 neonates meeting MIS-N criteria were identified. Presentation included cardiovascular compromise (77%), respiratory involvement (55%), and fever in (36%). Eighty-three percent of patients received steroids, and 76% received immunoglobulin. Respiratory support was provided to 60% of patients and inotropes to 45% of patients. Five (11%) neonates died. Conclusion: The common presentation of MIS-N included cardiorespiratory compromise with the possibility of high mortality. Neonates with MIS-N related to SARS-CoV-2 may be at higher risk of adverse outcomes.

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“…Baby was treated with IVIG, enoxaparin, aspirin, and antihypertensives, and was successfully discharged. Previously, there were similar reports of probable MIS-N with coronary dilatation [ 1 – 3 ] or thrombus [ 3 , 4 ].…”

mentioning

confidence: 67%

“…To the Editor: Some of the recent reports suggest the occurrence of multisystem inflammatory syndrome in neonates (MIS-N) [ 1 – 4 ]. We report here two cases of possible MIS-N.…”

mentioning

confidence: 99%

Neonatal Multisystem Inflammatory Syndrome (MIS-N) Associated with Maternal SARS-CoV-2 Exposure

Gupta

Tamatam

et al. 2022

Indian J Pediatr

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Multisystem Inflammatory Syndrome in Neonates following Maternal SARS-CoV-2 COVID-19 Infection

Cited by 20 publications

References 32 publications

SARS-CoV-2 Vaccines during Pregnancy and Breastfeeding: A Systematic Review of Maternal and Neonatal Outcomes

SARS-CoV-2 Vaccines during Pregnancy and Breastfeeding: A Systematic Review of Maternal and Neonatal Outcomes

Multisystemic Inflammatory Syndrome in Neonates: A Systematic Review

Neonatal Multisystem Inflammatory Syndrome (MIS-N) Associated with Maternal SARS-CoV-2 Exposure

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