Multisystem inflammatory syndrome in a male adolescent after his second Pfizer‐BioNTech COVID‐19 vaccine

Chai, Qing; Nygaard, Ulrikka; Schmidt, Rebecca Catherine; Zaremba, Tomás; Møller, Anne; Thorvig, Camilla Maria

doi:10.1111/apa.16141

Cited by 33 publications

(46 citation statements)

References 6 publications

(19 reference statements)

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“…However, in this case no precedent COVID-19 infection was identified, and the symptoms onset 12 days after SARS-Cov-2 vaccination strongly suggest a cause-effect relationship. Interestingly enough, albeit our patient needed hospitalization, he never appeared severely ill, differently from most cases of COVID-19 or vaccine-related MIS in children and adults [1] , [2] , [3] , [5] , [6] , [7] , [8] . In ours and in the other vaccine-related MIS, steroidal therapy and/or immunoglobulins proved to be efficacious, and no deaths were recorded.…”

Section: Discussionmentioning

confidence: 60%

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Multisystem Inflammatory Syndrome after Ad26.COV2.S vaccination

Bova¹,

Vigna

Gentile

2022

IDCases

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Background The multisystem inflammatory syndrome (MIS) is a rare and sometime life-threatening post-infectious complication of coronavirus disease 2019 (Covid-19) in children and adults. To date, only a very few reports have associated such systemic reaction with SARS-CoV-2 vaccination. Case report we describe a case that resembled MIS, in a 46-year-old White man, 12 days after vaccination with Ad26. COV2. S vaccine (Johnson &Johnson/Janssen), a recombinant adenovirus serotype 26 vector encoding the SARS-CoV-2 spike glycoprotein. The patient experienced high grade fever, cutaneous rash, severe weakness, pericardial effusion and raised inflammatory markers, which met the criteria for definition of MIS. The symptoms improved with steroidal therapy. Conclusions Our case suggests that MIS could occur after SARS-CoV-2 vaccination.

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Section: Discussionmentioning

confidence: 60%

“…The United States Centers for Diseases Control and Prevention is eagerly collecting data on this serious condition [4] . To date, such systemic reaction has been associated with vaccination against SARS-CoV-2 alone in a very few reports [5] , [6] , [7] , [8] . We describe a case that resembled MIS, after vaccination with Ad26.…”

Section: Introductionmentioning

confidence: 99%

Multisystem Inflammatory Syndrome after Ad26.COV2.S vaccination

Bova¹,

Vigna

Gentile

2022

IDCases

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“…14,26 Globally, MIS-C following COVID-19 vaccination has been reported in the literature for six persons <21 years of age. 23,[27][28][29][30] Two of these persons are from the United States and are included in our case series; both had evidence of SARS-CoV-2 infection. 23 A third reported person from the United States had received dose two of the Pfizer-BioNTech vaccine two months prior to presentation and had evidence of infection with a positive antinucleocapsid antibody test during MIS-C illness evaluation (NAAT was negative).…”

Section: Discussionmentioning

confidence: 99%

Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) Aged 12–20 Years in the United States Who Received COVID-19 Vaccine, December 2020 through August 2021

Yousaf

Cortese

Taylor

et al. 2022

Preprint

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BackgroundMultisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory condition associated with antecedent SARS-CoV-2 infection. In the United States, reporting of MIS-C after vaccination is required under COVID-19 vaccine emergency use authorizations. This case series describes persons aged 12–20 years with MIS-C following COVID-19 vaccination reported to passive surveillance systems or through clinician outreach to CDC.MethodsWe investigated potential cases of MIS-C after COVID-19 vaccination reported to CDC’s health department-based national MIS-C surveillance, the Vaccine Adverse Event Reporting System (VAERS, co-administered by CDC and the U.S. FDA), and CDC’s Clinical Immunization Safety Assessment Project (CISA) from December 14, 2020, to August 31, 2021. We describe cases meeting the CDC MIS-C case definition. Any positive SARS-CoV-2 serology test satisfied the case criteria although anti-nucleocapsid antibody indicates SARS-CoV-2 infection, while anti-spike protein antibody indicates either infection or COVID-19 vaccination.FindingsWe identified 21 persons with MIS-C after COVID-19 vaccination. Of these 21 persons, median age was 16 years (range, 12–20 years); 13 (62%) were male. All were hospitalized; 12 (57%) had intensive care unit admission, and all were discharged home. Fifteen (71%) of the 21 had laboratory evidence of past or recent SARS-CoV-2 infection, and six (29%) did not. Through August 2021, 21,335,331 persons aged 12–20 years had received ≥1 dose of COVID-19 vaccine, making the overall reporting rate for MIS-C following vaccination 1·0 case per million persons receiving ≥1 vaccine dose in this age group. The reporting rate for those without evidence of SARS-CoV-2 infection was 0·3 cases per million vaccinated persons.InterpretationIn our case series, we describe a small number of persons with MIS-C who had received ≥1 COVID-19 vaccine dose before illness onset. Continued reporting of potential cases and surveillance for MIS-C illnesses after COVID-19 vaccination is warranted.FundingThis work was supported by the Centers for Disease Control and Prevention Clinical Immunization Safety Assessment (CISA] Project contracts 200-2012-50430-0005 to Vanderbilt University Medical Center and 200-2012-53661 to Cincinnati Children’s Hospital Medical Center.Research in context panelEvidence before this studyMultisystem inflammatory syndrome in children (MIS-C), also known as paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS), is an uncommon, but serious, complication described after SARS-CoV-2 infection that is characterized by a generalized hyperinflammatory response. A review of the literature using PubMed identified reports of six persons aged 12–20 years who developed MIS-C following COVID-19 vaccination. Search terms used to identify these reports were: “multisystem inflammatory syndrome in children”, “MIS-C”, “MISC”, “multisystem inflammatory syndrome in adults”, “MIS-A”, “MISA”, “paediatric inflammatory multisystem syndrome”, and “PIMS-TS” each with any COVID-19 vaccine type. There were no exclusion criteria (i.e., all ages and languages).Added value of this studyWe conducted integrated surveillance for MIS-C after COVID-19 vaccination using two passive surveillance systems, CDC’s MIS-C national surveillance and the Vaccine Adverse Event Reporting System (VAERS), and clinician or health department outreach to CDC, including through Clinical Immunization Safety Assessment (CISA) Project consultations. We investigated reports of potential MIS-C occurring from December 14, 2020, to August 31, 2021, in persons aged 12–20 years any time after receipt of COVID-19 vaccine to identify those that met the CDC MIS-C case definition. Any positive serology test was accepted as meeting the CDC MIS-C case definition, although anti- nucleocapsid antibody is indicative of SARS-CoV-2 infection, while anti-spike protein antibody may be induced either by SARS-CoV-2 infection or by COVID-19 vaccination. We investigated 47 reports and identified 21 persons with MIS-C after receipt of COVID-19 vaccine. Of the 21 persons with MIS-C, median age was 16 years (range 12–20 years), and 13 (62%) were male. Fifteen (71%) had laboratory evidence of past or recent SARS-CoV-2 infection (positive SARS-CoV-2 nucleic acid amplification test [NAAT], viral antigen, or serology test before or during MIS-C illness evaluation), and 5 (33%) of those 15 had illness onset after their second vaccine dose. Six (29%) of 21 persons had no laboratory evidence of past or recent SARS-CoV-2 infection, and five of those six (83%) had onset of MIS-C after the second vaccine dose.Implications of all the available evidenceDuring the first nine months of the COVID-19 vaccination program in the United States, >21 million persons aged 12 to 20 years received ≥1 dose of COVID-19 vaccine as of August 31, 2021. This case series describes MIS-C in 21 persons following vaccine receipt during this time period; the majority of persons reported also had evidence of SARS-CoV-2 infection. The surveillance has limitations, but our findings suggest that MIS-C as identified in this report following COVID-19 vaccination is rare. In evaluating persons with a clinical presentation consistent with MIS-C after COVID-19 vaccination it is important to consider alternative diagnoses, and anti-nucleocapsid antibody testing may be helpful. Continued surveillance for MIS-C illness after COVID-19 vaccination is warranted, especially as pediatric COVID-19 vaccination expands. Providers are encouraged to report potential MIS-C cases after COVID-19 vaccination to VAERS.

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“…Dear Editor, we would like to share ideas on ‘Multisystem inflammatory syndrome in a male adolescent after his second Pfizer‐BioNTech COVID‐19 vaccine 1 ’. Chai et al noted that ‘ Multisystem inflammatory syndrome (MIS) in children (MIS‐C) is a complication of the severe acute respiratory syndrome co….. SARS‐CoV‐2 vaccines, especially in males aged 12–17 years .…”

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confidence: 99%

“…Chai et al noted that ‘ Multisystem inflammatory syndrome (MIS) in children (MIS‐C) is a complication of the severe acute respiratory syndrome co….. SARS‐CoV‐2 vaccines, especially in males aged 12–17 years . 1 ’ Adverse effect of COVID‐19 vaccine is the present clinical consideration in clinical pediatric. The present case is an example.…”

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confidence: 99%

Multisystem inflammatory syndrome and COVID‐19 vaccine

Sookaromdee¹,

Wiwanitkit

2021

Acta Paediatrica

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Dear Editor, we would like to share ideas on 'Multisystem inflammatory syndrome in a male adolescent after his second Pfizer-BioNTech COVID-19 vaccine 1 '. Chai et al. noted that 'Multisystem inflammatory syndrome (MIS) in children (MIS-C) is a complication of the severe acute respiratory syndrome co….. SARS-CoV-2 vaccines, especially in males aged 12-17 years. 1 ' Adverse effect of COVID-19 vaccine is the present clinical consideration in clinical pediatric. The present case is an example. The exact cause of MIS is not yet clarified. The process might be immunopathological process similar to pathogenesis of MIS following COVID-19. After a COVID-19 administration, increased blood viscosity 2 occurs and might lead to myocarditis. 3 The patient with previous COVID-19 might have more risk to get a problem of COVID-19 vaccine-induced hyperviscosity. 2 In an area with high prevalence of disease, a child with previous silent COVID-19 is possible and the risk has to be monitored.

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Multisystem inflammatory syndrome in a male adolescent after his second Pfizer‐BioNTech COVID‐19 vaccine

Cited by 33 publications

References 6 publications

Multisystem Inflammatory Syndrome after Ad26.COV2.S vaccination

Multisystem Inflammatory Syndrome after Ad26.COV2.S vaccination

Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) Aged 12–20 Years in the United States Who Received COVID-19 Vaccine, December 2020 through August 2021

Multisystem inflammatory syndrome and COVID‐19 vaccine

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