Multisystem disorder after exposure to paint stripper (Nitromors)

Abstract

Interaction of ethinyloestradiol with ascorbic acid SIR,-The short report by Dr D J Back and others (9 May, p 1516) is admirably conservative of your editorial space but tantalisingly incomplete. If the toxic effects of the enhancement of ethinyloestradiol plasma concentration by ascorbic acid rise in parallel with the therapeutic activity, then the net benefit is nil. Furthermore, the authors have not discussed whether there is any similar interaction with the progestogen component. The balance of oestrogenic and progestogenic activity of the combined oral contraceptives is important in relation to efficacy and probably to the incidence of adverse effects on the circulatory system.' CLIFFORD KAY