Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition?

Gołębiowski, Tomasz; Kuźniar, J; Porażko, Tomasz; Wojtala, R; Konieczny, Andrzej; Krajewska, Magdalena; Klinger, Marian

doi:10.3390/ijerph19042297

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…RCS exposure can also lead to lung cancer (IARC 1997 ), pneumoconiosis (Hua et al 2018 ), tuberculosis, chronic bronchitis, emphysema, and chronic obstructive pulmonary disease (Mason and Thompson 2010 ). RCS is a significant risk factor for developing immunologic and autoimmune diseases such as chronic renal disease (Steenland et al 2001 ), monoclonal gammopathy and amyloidosis (Gołębiowski et al 2022 ), Sjogren’s syndrome (Ziebelman et al 2022 ), scleroderma (Haustein et al 1990 ), rheumatoid arthritis, systemic lupus erythematosus, and sarcoidosis (Mason and Thompson 2010 ).…”

Section: Introductionmentioning

confidence: 99%

A systematic review of the effectiveness of dust control measures adopted to reduce workplace exposure

Anlimah

Gopaldasani

MacPhail

et al. 2023

Environ Sci Pollut Res

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The recent increase in silicosis cases in several countries casts doubt on dust control practices and their effectiveness in preventing respirable crystalline silica (RCS) exposure. Apart from silicosis, RCS may lead to other illnesses, health-related quality of life losses for workers and their families, and economic losses for companies. Thus, this systematic literature review examined the effectiveness of interventions employed to prevent exposure to RCS and increase the use of dust control measures. The review used keywords related to dust control interventions to search seven databases. Search results were screened and extracted for synthesis. The narrative synthesis showed the extent of research investment in China. In several designs and combinations, the interventions utilized water, surfactant, foam, and air currents to reduce dust exposure. These interventions offer varying degrees of dust control effectiveness against RCS and respirable dust. Although evidence indicates that interventions significantly decrease dust concentration levels, the control measures in place may not effectively prevent workplace overexposure to RCS. The review found that education and training interventions are employed to improve dust controls and respiratory protective equipment (RPE) use. Also, marketing strategies promote the use of RPE. These interventions can increase the frequency of use of RPE and the adoption of best practice dust control measures. Interventions increase knowledge, awareness, and attitudes about RPE usage and generate positive perceptions while reducing misconceptions. However, the benefits obtained from an intervention may diminish after its implementation, indicating that the interventions may not continually motivate workers to adopt control measures or use RPE.

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Section: Introductionmentioning

confidence: 99%

A systematic review of the effectiveness of dust control measures adopted to reduce workplace exposure

Anlimah

Gopaldasani

MacPhail

et al. 2023

Environ Sci Pollut Res

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“…Amyloids can accumulate not only in brain but also in different tissues and body organs that result in clinical syndromes [ 17 ]. A recent study has shown multiorgan amyloidosis in a coal miner [ 22 ]. In a Swedish study on amyloidosis, all of the 33 cases had simultaneous pulmonary and cardiac involvements [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Label-free detection and quantification of ultrafine particulate matter in lung and heart of mouse and evaluation of tissue injury

et al. 2022

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While it is known that air borne ultrafine particulate matter (PM) may pass through the pulmonary circulation of blood at the alveolar level between lung and heart and cross the air-blood barrier, the mechanism and effects are not completely clear. In this study the imaging method fluorescence lifetime imaging microscopy is adopted for visualization with high spatial resolution and quantification of ultrafine PM particles in mouse lung and heart tissues. The results showed that the median numbers of particles in lung of mice exposed to ultrafine particulate matter of diameter less than 2.5 µm was about 2.0 times more than that in the filtered air (FA)-treated mice, and about 1.3 times more in heart of ultrafine PM-treated mice than in FA-treated mice. Interestingly, ultrafine PM particles were more abundant in heart than lung, likely due to how ultrafine PM particles are cleared by phagocytosis and transport via circulation from lungs. Moreover, heart tissues showed inflammation and amyloid deposition. The component analysis of concentrated airborne ultrafine PM particles suggested traffic exhausts and industrial emissions as predominant sources. Our results suggest association of ultrafine PM exposure to chronic lung and heart tissue injuries. The current study supports the contention that industrial air pollution is one of the causative factors for rising levels of chronic pulmonary and cardiac diseases.

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Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition?

Cited by 2 publications

References 27 publications

A systematic review of the effectiveness of dust control measures adopted to reduce workplace exposure

A systematic review of the effectiveness of dust control measures adopted to reduce workplace exposure

Label-free detection and quantification of ultrafine particulate matter in lung and heart of mouse and evaluation of tissue injury

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