Multistimulus Responsive Biointerfaces with Switchable Bioadhesion and Surface Functions

Yang, Zhou; Zheng, Yanjun; Wei, Ting; Qu, Yangcui; Wang, Yaran; Zhan, Wenjun; Zhang, Yanxia; Pan, Guoqing; Li, Dan; Yu, Qian; Chen, Hong

doi:10.1021/acsami.9b18505

Cited by 61 publications

(46 citation statements)

References 67 publications

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“…Stimuli‐responsiveness is an essential feature for smart bioadhesives, and various stimuli‐responsive biopolymers‐based bioadhesives have been developed to meet specific clinical needs [ 78,104 ] A cis ‐diol‐based glue adhesive made using alginate‐boronic acid can cure at a physiological pH value, leading to spontaneous hydrogel formation. [ 78 ] The glue was effective for enhanced attachment between tissue (e.g., intestines) and implantable hydrogels.…”

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

“…Li and colleagues developed a bilayer adhesive platform with reversible sol‐gel transition by pretreating a substrate with tannic acid to generate a thin film for further bonding to the polymer matrix. [ 104f ] The temperature‐dependent sol‐gel/gel‐sol transition results from the temperature‐triggered phase transition of the polymer matrix. [ 104f ] Thermo‐responsive bioadhesives based on gelatin and chondroitin sulfate have been developed for minimally invasive surgery.…”

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

“…[ 104f ] The temperature‐dependent sol‐gel/gel‐sol transition results from the temperature‐triggered phase transition of the polymer matrix. [ 104f ] Thermo‐responsive bioadhesives based on gelatin and chondroitin sulfate have been developed for minimally invasive surgery. [ 7b ] By changing temperature between 20 and 37°C, the high and low adhesion of as prepared bioadhesives to tissue surfaces have been achieved.…”

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

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Emerging Biopolymer‐Based Bioadhesives

Martinez

et al. 2021

Macromolecular Bioscience

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Bioadhesives have been widely used in healthcare and biomedical applications due to their ease‐of‐operation for wound closure and repair compared to conventional suturing and stapling. However, several challenges remain for developing ideal bioadhesives, such as unsatisfied mechanical properties, non‐tunable biodegradability, and limited biological functions. Considering these concerns, naturally derived biopolymers have been considered good candidates for making bioadhesives owing to their ready availability, facile modification, tunable mechanical properties, and desired biocompatibility and biodegradability. Over the past several years, remarkable progress has been made on biopolymer‐based adhesives, covering topics from novel materials designs and advanced processing to clinical translation. The developed bioadhesives have been applied for diverse applications, including tissue adhesion, hemostasis, antimicrobial, wound repair/tissue regeneration, and skin‐interfaced bioelectronics. Here in this comprehensive review, recent progress on biopolymer‐based bioadhesives is summarized with focuses on clinical translations and multifunctional bioadhesives. Furthermore, challenges and opportunities such as weak adhesion strength at the hydrated state, mechanical mismatch with tissues, and unfavorable immune responses are discussed with an aim to facilitate the future development of high‐performance biopolymer‐based bioadhesives.

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Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

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Emerging Biopolymer‐Based Bioadhesives

Martinez

et al. 2021

Macromolecular Bioscience

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“…Thermoresponsive systems have attracted considerable interests for their ability to change the swelling behaviors and network structures dramatically in response to temperature stimuli, which have potential applications in biomedical and biochemical fields such as drug delivery, protein separation and cell detachment (1)(2)(3). Poly(N-isopropylacrylamide) (PNIPAAm) is one of the most attractive thermoresponsive polymers.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of thermoresponsive poly(N-isopropylacrylamide) copolymers with enhanced hydrophilicity

Fan

et al. 2020

E-Polymers

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The poly(N-isopropylacrylamide) copolymers with the enhanced hydrophilicity were synthesized by free radical polymerization from a mixture of the monomers N-isopropylacrylamide (NIPAAm), N-vinyl pyrrolidone (NVP), hydroxypropyl methacrylate (HPM) and 3-trimethoxysilypropyl methacrylate (TMSPM) at different feeding ratios. The attenuated total reflectance-Fourier transform infrared spectrometry (ATR-FTIR), nuclear magnetic resonance (1H-NMR) and gel permeation chromatography (GPC) were applied to characterize the resultant copolymers. The lower critical solution temperature (LCST) of the copolymers was determined via dynamic light scattering (DLS). By alternating the molar ratios of NIPAAm and NVP, the copolymers were synthesized to have their own distinctive LCST from 25°C to 40°C. Regardless of the starting feed ratio used, the final copolymers had the similar monomeric ratio as planned. The copolymer films were then formed on platinum wafers by drop coating and thermal annealing owing to 3-trimethoxysilyl crosslinking and reacting with hydroxyl groups. The surface wettability and morphology of the specimens were observed using contact angle measurements and scanning electron microscopy (SEM), respectively. The results demonstrated that with the increase of the NVP content, the film surface became more hydrophilic. The surface microstructure of the thermoresponsive films varied depending on the copolymer composition and ambient temperature. The experimental results indicated that the addition of NVP not only increased the LCST of copolymers but also improved the hydrophilicity of the products derived from the copolymers. This ability to elevate the LCST of the polymers provides excellent flexibility in tailoring transitions for specific uses, like controlled drug release and nondestructive cell harvest.

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“…

Stimulus-responsive polymers and their composites are popular subjects of modern materials science [1,2]. Among many, they are utilized as pH-responsive intelligent drug delivery and release systems [3], photo-or electroresponsive actuators [4,5], or even multistimulus-responsive biointerfaces [6]. The stimulus-responsivity of such composites can influence many properties, like shape, size [7], density, swelling degree, and the real-time regulation of surface wetting properties.

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mentioning

confidence: 99%