Multistate study of the epidemiology of clubfoot

Parker, Samantha E.; Cara, T.; Strickland, Matthew; Olney, Richard S.; Rickard, Russel; Marengo, Lisa; Wang, Ying; Hashmi, S. Shahrukh; Meyer, Robert E.

doi:10.1002/bdra.20625

Cited by 94 publications

(89 citation statements)

References 26 publications

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“…However, the professional background, age of the parents/caregivers and relationship to the child with clubfoot does not affect the treatment seeking behaviour for their children. This is contrary to a study conducted in the United States by Parker et al (2009), the authors found that maternal age, parity, education, and marital status were significantly associated with clubfoot.…”

Section: Socio-demographic Characteristicscontrasting

confidence: 99%

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Perceptions Regarding Medical Management of Clubfoot in Kenya

Kingau¹,

Rhoda²,

Mlenzana³

et al. 2015

Int J Phys Med Rehabil

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Section: Socio-demographic Characteristicscontrasting

confidence: 99%

“…Additionally, a study by Baker et al (2003) estimated the prevalence of clubfoot to be 2.57 per 1000 live births in the United States. Likewise, Parker et al (2009) indicated that the prevalence of clubfoot among african american was 1.14 per 1000 live births.…”

Section: Prevalence Of Clubfootmentioning

confidence: 99%

Perceptions Regarding Medical Management of Clubfoot in Kenya

Kingau¹,

Rhoda²,

Mlenzana³

et al. 2015

Int J Phys Med Rehabil

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“…The majority (74%) of the CHOP cohort is Caucasian and since the prevalence of club foot within the general Caucasian population is ~1:1,000 patients, the prevalence of club foot occurs approximately 30 times more often within 22q11.2DS as compared to the general Caucasian population. Moreover, the bilateral:unilateral and male:female ratio are comparable with the general population (Krogsgaard et al, 2006; Parker et al, 2009; Stone et al, 2017; Werler et al, 2013). Last, we did not find a relation between the presence of club foot and the presence of a CHD and/or a cleft palate.…”

Section: Discussionmentioning

confidence: 60%

“…The prevalence of congenital isolated club foot in the general population differs among multiple ethnic populations, but is approximately 1.2–6 per 1,000 individuals. Within the group of patients with isolated club foot the male:female ratio is 2:1 and half of the patients have a bilateral club foot (Cartlidge, 1983; Krogsgaard et al, 2006; Parker et al, 2009; Stone, Martis, & Crawford, 2017; Werler et al, 2013). In studies on club foot within 22q11.2DS the prevalence ranges from 1.1 to 13.3%, which seems to be higher as compared to the general population (Homans et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Club foot in association with the 22q11.2 deletion syndrome: An observational study

Homans

Crowley

Chen

et al. 2018

American J of Med Genetics Pt A

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The 22q11.2 Deletion Syndrome (22q11.2DS) occurs in ~1:3,000–6,000 individuals. Features less typically associated with 22q11.2DS, such as orthopedic manifestations, may be overlooked or may not lead to appropriate diagnostic testing. Club foot has a general population prevalence of ~1:1,000 and has been occasionally described in association with 22q11.2DS. Our hypothesis is that the prevalence of club foot is higher in patients with 22q11.2DS. We performed a retrospective review in two specialized 22q11.2DS centers to determine the prevalence of club foot. “True club foot” requires treatment (either conservative or surgical), therefore we only included those patients with proof of treatment. We investigated whether congenital heart disease (CHD) and/or cleft palate were associated with the presence of club foot within 22q11.2DS. The records of 1,466 patients were reviewed. Of these, 48 (3.3%) had confirmation of club foot (95% Confidence Interval: 2.4–4.3): 22 (46%) had a bilateral, 12 (25%) left, and 14 (29%) right club foot. Within our study, neither a CHD and/or a cleft palate were associated with a club foot. The prevalence of club foot in 22q11.2DS is 30 times higher than that observed in the general population. This suggests the diagnosis of club foot, especially in the face of other typically associated abnormalities of 22q11.2DS, should provoke consideration of 22q11.2DS as an underlying diagnosis, particularly in the neonatal setting.

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“…This however varies between races, ethnicities and countries. In the USA, a study reported 1.29 /1000 births, while in Africa, some studies like in Malawi reported 2/1000 births and in Nigerian, reported 3.4/1000 births (Parker et al, 2009;Mkandawire and Kaunda, 2004;Ukoha et al, 2011). There is usually an underestimation of the true incidence due to under-reporting and missing cases.…”

Section: Introductionmentioning

confidence: 98%

Descriptive epidemiology and predisposing factors to idiopathic talipes equinovarus in South South Nigeria

Asuquo¹,

Innocent²,

Anisi³

et al. 2016

J. Public Health Epidemiol.

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Talipes equinovarus (Clubfoot) is the commonest foot deformity with variable incidence across races. Exact etiology remains elusive. The objective of this study is to describe the epidemiology of clubfoot in our centre, looking for predisposing factors. This is a descriptive clinic based epidemiologic study of 106 feet belonging to 69 subjects from January 2014 -December 2015 was conducted. Structured questionnaires were administered to clinically confirmed clubfoot subject's guardian or biologic mothers. Phenotypic data from clubfoot subject were also recorded. Analysis was done using IBM SPSS version 22 for windows. Results revealed the age range of the patients as 3 days to 9 years, with a mean age of 46.17 ± 92.03 weeks. Thirty-seven (53.7%) patients had bilateral deformity while 13 (18.8%) patients had right-sided deformity, and 19 (27.5%) patients had left-sided deformity. Majority 40 (58.0%) of the patients were firstborn out of which 28 were males. Only 2 (2.89%) patients are products of multiple gestations. All mothers were none smokers and there was no reported family history of foot deformities or clubfoot. The mean maternal age was 25.81 years ± 4.99 years. The average length/height of patients at presentation was 64.27 ± 23.93 cm. The average shoulder span of the patients at presentation was 23.93 ± 15.86 cm. The study thus revealed that young maternal age, gender and firstborn are predisposing factors in the etiology of clubfoot.

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Multistate study of the epidemiology of clubfoot

Cited by 94 publications

References 26 publications

Perceptions Regarding Medical Management of Clubfoot in Kenya

Perceptions Regarding Medical Management of Clubfoot in Kenya

Club foot in association with the 22q11.2 deletion syndrome: An observational study

Descriptive epidemiology and predisposing factors to idiopathic talipes equinovarus in South South Nigeria

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