Multistage magnetic particle separator

Todd, Paul; Cooper, Ryan P.; Doyle, James R.; Dunn, Scott; Vellinger, John C.; Deuser, Mark S.

doi:10.1016/s0304-8853(00)01253-1

Cited by 23 publications

(11 citation statements)

References 11 publications

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“…One of the most commonly employed magnet configuration in magnetophoresis applications, able to maximize field distribution anisotropy, is the quadrupolar arrangement which creates a magnetic gradient radially outward from the center of the flow column [25]. In a variant of this, the fluid is static, while an applied magnetic field is moved up the container [26]. The particles move in the resulting field gradient at a velocity dependent on their magnetophoretic mobility.…”

Section: Magnetic Separationmentioning

confidence: 99%

Magnetic Field-Based Technologies for Lab-on-a-Chip Applications

Iacovacci¹,

Lucarini²,

Ricotti³

et al. 2016

Lab-on-a-Chip Fabrication and Application

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In the last decades, LOC technologies have represented a real breakthrough in the field of in vitro biochemical and biological analyses. However, the integration of really complex functions in a limited space results extremely challenging and proper working principles should be identified. In this sense, magnetic fields revealed to be extremely promising. Thanks to the exploitation of external magnetic sources and to the integration of magnetic materials, mainly high aspect ratio micro-/nanoparticles, non-contact manipulation of biological and chemical samples can be enabled. In this chapter, magnetic field-based technologies, their basic theory, and main applications in LOC scenario will be described by foreseeing also a deeper interaction/integration with the typical technologies of microrobotics. Attention will be focused on magnetic separation and manipulation, by taking examples coming from traditional LOC devices and from microrobotics.

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Section: Magnetic Separationmentioning

confidence: 99%

Magnetic Field-Based Technologies for Lab-on-a-Chip Applications

Iacovacci¹,

Lucarini²,

Ricotti³

et al. 2016

Lab-on-a-Chip Fabrication and Application

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“…Figure 4a is a schematic diagram of the socalled quadrupole magnet configuration, where four magnets are arranged in order to induce a maximum magnetic field gradient at the outer side of a liquid carrying tube, inserted into the free space between the magnets (Hatch and Stelter 2001). Besides this, other permanent magnet configurations have been proposed for separation (Haik et al 1999;Todd et al 2001;Nedelcu and Watson 2002;Hoffmann and Franzreb 2004). Figure 4b is a calculation of the magnitude of the magnetic force (using Eq.…”

Section: Magnetic Separationmentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

496

555

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This review describes recent advances in the handling and manipulation of magnetic particles in microfluidic systems. Starting from the properties of magnetic nanoparticles and microparticles, their use in magnetic separation, immuno-assays, magnetic resonance imaging, drug delivery, and hyperthermia is discussed. We then focus on new developments in magnetic manipulation, separation, transport, and detection of magnetic microparticles and nanoparticles in microfluidic systems, pointing out the advantages and prospects of these concepts for future analysis applications.

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“…Similar exercises to this one could be applied to other kinetic separations such as sedimentation and magnetophoresis [19].…”

Section: Pseudoequilibrium Analysismentioning

confidence: 98%

Multistage electrophoresis II: Treatment of a kinetic separation as a pseudoequilibrium process

2002

Self Cite

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An electrophoresis device is described which separates cells, particles, proteins and other separands by collecting samples having decreasing electrophoretic mobility in a train of inverted cavities while an electric field is applied between the inverted cavities and a sample cuvette containing a mixture of cells, particles, proteins or other separands. A circular plate is provided for the inverted cavities, and this circular plate is rotated to collect fractions. The system utilizes an innovative purification method that combines free electrophoresis and multistage extraction in an instrument capable of separating living cells, particles, and proteins in useful quantities at high concentrations. Most multistage processes are based on equilibrium separations, but electrophoresis is a kinetic separation; therefore, a pseudoequilibrium paradigm was developed for use in optimizing separation parameters including number of stages and electrophoresis time per stage. This paradigm allows the application of McCabe-Thiele type analysis, and it was calculated, for example, that two separands differing by 20% in electrophoretic mobility can be purified to 95% purity with acceptable yield in about seven stages. Laboratory experiments demonstrated a 95% purification in four stages of a separand originally present at 4% when electrophoretic mobilities differed by 80%.

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Multistage magnetic particle separator

Cited by 23 publications

References 11 publications

Magnetic Field-Based Technologies for Lab-on-a-Chip Applications

Magnetic Field-Based Technologies for Lab-on-a-Chip Applications

Magnetic bead handling on-chip: new opportunities for analytical applications

Multistage electrophoresis II: Treatment of a kinetic separation as a pseudoequilibrium process

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