Multistage fractionation of pine bark by liquid and supercritical carbon dioxide

Barbini, Stefano; Jaxel, Julien; Karlström, Katarina; Rosenau, Thomas; Potthast, Antje

doi:10.1016/j.biortech.2021.125862

Cited by 15 publications

(14 citation statements)

References 37 publications

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“…Recent studies, using wood or bark as the starting material, employed the sc-CO 2 extraction to the enrichment of different compounds. In this context, Barbini et al [ 19 ] extracted pine bark using subcritical and supercritical CO 2 . The first step allowed a selective enrichment of the extract with unsaturated fatty acids despite the low extraction yields obtained.…”

Section: Introductionmentioning

confidence: 99%

Pressurized Solvent Extraction of Paulownia Bark Phenolics

2021

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Paulownia bark is mostly utilized jointly with wood, but the possibility of a separate valorization through the pressurized extraction of bark bioactives has been assessed. Subcritical water extraction and supercritical CO2 extraction are green technologies allowing shorter times than conventional solvent extraction under atmospheric shaken conditions. Subcritical water extraction was carried out at temperatures ranging from 140 to 240 °C and supercritical CO2 extraction was performed at different pressures (10, 20 and 30 MPa), temperatures (35, 45 and 55 °C) and ethanol concentrations (0, 10 and 15% (w/w)). Subcritical water extraction under a non-isothermal operation during heating up to 160 °C (19 min) provided extraction yields up to 30%, and the extracts contained up to 7% total phenolics with an ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging capacity equivalent to 35% the activity of Trolox, whereas at 240 °C, the yield decreased to 20%, but the phenolic content reached 21%, and the antiradical activity was equivalent to 85% of Trolox. Supercritical CO2 extraction at 30 MPa, 45 °C and 30 min reached a global yield of 2% after 180 min of extraction, but the product showed very low antiradical capacity. Gallic acid, vanillic acid, vanillin and apigenin were the major phenolic compounds found in the extracts.

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Section: Introductionmentioning

confidence: 99%

Pressurized Solvent Extraction of Paulownia Bark Phenolics

2021

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“…Recently other research work considering multistage extraction strategies were applied for the valorization of bark wastes. Multistage fractionation of pine bark was performed using subcritical and supercritical SCO 2 at increasing pressures and temperatures [ 27 ]. Results revealed that after removing most of the lipophilic compounds in initials steps, the last supercritical extraction with ethanol as co-solvent, facilitates the recovery of more polar compounds, such as phenolics and glycerol, released through the depolymerization reactions of lignin and suberin [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Multistage fractionation of pine bark was performed using subcritical and supercritical SCO 2 at increasing pressures and temperatures [ 27 ]. Results revealed that after removing most of the lipophilic compounds in initials steps, the last supercritical extraction with ethanol as co-solvent, facilitates the recovery of more polar compounds, such as phenolics and glycerol, released through the depolymerization reactions of lignin and suberin [ 27 ]. Bento et al (2022) presented a green strategy to sequentially extract Pinus radiata bark, exploring SCO 2 extraction and a biocompatible ionic liquid catalyst.…”

Section: Discussionmentioning

confidence: 99%

“Smart Extraction Chain” with Green Solvents: Extraction of Bioactive Compounds from Picea abies Bark Waste for Pharmaceutical, Nutraceutical and Cosmetic Uses

et al. 2022

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Secondary metabolites from the sawmill waste Picea abies bark were extracted using an innovative two-step extraction that includes a first step with supercritical CO2 (SCO2) and a second step using green solvents, namely ethanol, water, and water ethanol mixture. Maceration (M), ultrasound assisted extraction (UAE) and microwave assisted extraction (MAE) techniques were applied in the second step. A total of nineteen extract were obtained and yield were compared. Bark extracts were characterized by LC-DAD-MSn and classes of compounds were quantified as abietane derivatives, piceasides, flavonoids, and phenolics to compare different extractions. Obtained extracts were studied by in vitro assay to evaluate potential pharmaceutical, nutraceutical and cosmetic uses assessing the antioxidant activity as well as the inhibitory activity on target enzymes. Results show that the “smart extraction chain” is advantageous in term of yield of extraction and phytoconstituent concentration. SCO2 extract, presenting a unique composition with a large amount of abietane derivatives, exerted the best activity for amylase inhibition compared to the other extracts.

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“…When talking about CO 2 , topics such as greenhouse gases, global warming and the relevant environmental considerations maybe occur to someone. However, the magic effects of its supercritical state on the development of numerous fields are undeniable, including extraction of organic compounds [7][8][9][10][11] , drug solubility measurement [12][13][14][15][16][17] , particle production [18][19][20] , power generation 21 , polymer synthesis and processing 22,23 , impregnation process 24 , tissue engineering 25 and food industry 26 . Moreover, low toxicity, safety, low environmental impacts and accessible critical conditions make CO 2 a special and the most frequently used supercritical solvent, both on the laboratory scale and in the industrial level processes.…”

Section: Solubility Of Palbociclib In Supercritical Carbon Dioxide Fr...mentioning

confidence: 99%

Solubility of palbociclib in supercritical carbon dioxide from experimental measurement and Peng–Robinson equation of state

Sodeifian

Hsieh

Tabibzadeh

et al. 2023

Sci Rep

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Palbociclib is a poorly water-soluble medicine which acts against metastatic breast cancer cells. Among various techniques to improve the solubility of this medicine, applying supercritical technologies to produce micro- and nano-sized particles is a possible option. For this purpose, extraction of solubility data is required. In this research, the solubility of palbociclib in supercritical carbon dioxide (ScCO2) at different equilibrium conditions was measured at temperatures between 308 and 338 K and pressures within 12–27 MPa, for the first time. The minimum and maximum solubility data were found to be 8.1 × 10–7 (at 338 K and 12 MPa) and 2.03 × 10–5 (at 338 K and 27 MPa), respectively. Thereafter, two sets of models, including ten semi-empirical equations and three Peng–Robinson (PR) based integrated models were used to correlate the experimental solubility data. Bian’s model and PR equation of state using van der Waals mixing rules (PR + vdW) showed better accuracy among the examined semi-empirical and integrated models, respectively. Furthermore, the self-consistency of the obtained data was confirmed using two distinct semi-empirical models. At last, the total and vaporization enthalpies of palbociclib solubility in ScCO2 were calculated from correlation results of semi-empirical equations and estimated to be 40.41 and 52.67 kJ/mol, respectively.

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Multistage fractionation of pine bark by liquid and supercritical carbon dioxide

Cited by 15 publications

References 37 publications

Pressurized Solvent Extraction of Paulownia Bark Phenolics

Pressurized Solvent Extraction of Paulownia Bark Phenolics

“Smart Extraction Chain” with Green Solvents: Extraction of Bioactive Compounds from Picea abies Bark Waste for Pharmaceutical, Nutraceutical and Cosmetic Uses

Solubility of palbociclib in supercritical carbon dioxide from experimental measurement and Peng–Robinson equation of state

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