Multistage Carcinogenesis: Cell and Animal Models

Kulesz‐Martin, Molly; Ouyang, Xiaoming; Barling, A.; Gallegos, Jayme R.; Liu, Y.; Medler, Terry R.

doi:10.1016/b978-0-12-801238-3.02218-2

Cited by 4 publications

(3 citation statements)

References 173 publications

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“…Cell canceration is caused by protooncogene and antioncogene mutations in cells under the action of carcinogenic factors [ 29 ]. External factors in cell carcinogenesis include physical, chemical, and viral carcinogens [ 30 ]. Plentiful studies have testified that external stimuli, such as high temperature, hypoxia, low/high glucose, changes in calcium concentration, nutrient deficiency, acidosis, and heavy metals, can improve cell proliferation capacity [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

miR‐4454 Promotes Hepatic Carcinoma Progression by Targeting Vps4A and Rab27A

Lin

Zhang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Hepatocellular carcinoma (HCC) has high morbidity and mortality. MicroRNAs (miRNAs), which could be regulated by cancer-derived exosomes, play critical regulatory roles in the initiation and development of cancer. However, the expressions, effects, and mechanisms of abundant miRNAs regulated by HCC cancer-derived exosomes in HCC remain largely unclear. Exosomes of HepG2 cells under heat shock, TGF-β1, doxorubicin, acid and hypoxia/reoxygenation (H/R) conditions, and exosomes were successfully identified by transmission electron microscopy and Western blot analysis. The identified exosomes were then applied to evaluate the miRNA expression profiles by RNA sequencing. Mechanically, we discovered that doxorubicin was upregulated, TGF-β1 downregulated the expressions of Vps4A, Rab27A, Alix, and Hrs in HepG2 cells and exosomes, and Vps4A and Rab27A, as target genes for miR-4454, could also be downregulated by miR-4454. Functionally, we revealed that miR-4454 inhibitor and miR-4454 inhibitor-mediated exosomes could markedly suppress proliferation, migration, invasion, and vascularization and accelerate cycle arrest, apoptosis, and ROS of HepG2 cells. This study provided many potential HCC cancer-derived exosome-mediated miRNAs in HCC under 5 different stimulus conditions. Meanwhile, we certified that miR-4454 in exosomes could provide a novel and effective mechanism for HCC function.

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Section: Discussionmentioning

confidence: 99%

miR‐4454 Promotes Hepatic Carcinoma Progression by Targeting Vps4A and Rab27A

Lin

Zhang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…The human body has meticulously regulated control mechanisms that involve signals prompting cells to cease their growth and initiate programmed cell death. Nevertheless, if these mechanisms malfunction, cells can exhibit irregular traits, such as uncontrolled growth, potentially leading to the formation of tumors [147]. Cancer is recognized as a leading global cause of mortality, marked by the unregulated proliferation of normal human cells [148].…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Clove Essential Oil: Chemical Profile, Biological Activities, Encapsulation Strategies, and Food Applications

Liñán-Atero,

Aghababaei,

García

et al. 2024

Antioxidants

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Plants have proven to be important sources for discovering new compounds that are useful in the treatment of various diseases due to their phytoconstituents. Clove (Syzygium aromaticum L.), an aromatic plant widely cultivated around the world, has been traditionally used for food preservation and medicinal purposes. In particular, clove essential oil (CEO) has attracted attention for containing various bioactive compounds, such as phenolics (eugenol and eugenol acetate), terpenes (β-caryophyllene and α-humulene), and hydrocarbons. These constituents have found applications in cosmetics, food, and medicine industries due to their bioactivity. Pharmacologically, CEO has been tested against a variety of parasites and pathogenic microorganisms, demonstrating antibacterial and antifungal properties. Additionally, many studies have also demonstrated the analgesic, antioxidant, anticancer, antiseptic, and anti-inflammatory effects of this essential oil. However, CEO could degrade for different reasons, impacting its quality and bioactivity. To address this challenge, encapsulation is viewed as a promising strategy that could prolong the shelf life of CEO, improving its physicochemical stability and application in various areas. This review examines the phytochemical composition and biological activities of CEO and its constituents, as well as extraction methods to obtain it. Moreover, encapsulation strategies for CEO and numerous applications in different food fields are also highlighted.

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“…With the development of genetically engineered mouse models, the functional consequences and dynamics of genetic changes in tissues can be determined according to the stages of carcinogenesis. Cooperative models linking cell culture methods and relevant animal models offer simple quantitative approaches to assess the oncogenic potential of carcinogens and immunity, as well as the role of individual potential "can-didates" in cancer genes in mechanisms of its development (Kulesz-Martin et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

A modern look at the molecular-biological mechanisms of breast tumours in dogs

Bilyi

Gerdeva

Samoilіuk

et al. 2020

Regul. Mech. Biosyst.

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High morbidity and increase in the number of registrations of breast tumours in dogs, their wide application as biological models, discussion of numerous questions of oncogenesis, and the lack of a uniform/unified methodological approach to the study of molecular and biological mechanisms of treatment of cancer determine the relevance of the problem of cancer both in humans and in our domestic companions. The analysis of publications allowed us to establish the following patterns of carcinogenesis. The peculiarities of the biological behaviour of breast tumours depend on their pathomorphological structure. Genetic predisposition to breast cancer is characteristic only in the single breed aspect. Environmental factors are of critical relevance to carcinogenesis : chemical pollutants initiate oncogenesis indirectly – by altering the expression of several receptors, impaired endocrine balance and direct mutagenic effects. Reproductive status plays a key role in the initiation and progression of breast tumours by reducing the expression of estrogen, progesterone and prolactin receptor genes. The inflammatory response that accompanies the neoplasia process is characterized by increased production of cytokines, cyclooxygenase-2, interleukins (IL-1, IL-6, IL-8), vascular endothelial growth receptors, and impaired hemostatic status (oxidative stress), which promotes progression of disease. In breast cancer in dogs, genomic instability leads to genomic aberrations, and subsequently, mutations that support the proliferation, survival and dissemination of neoplastic cells. The initiation and progression of mammary gland tumours is provided by cancer stem cells by disrupting the regulation of precursor cell self-renewal, which also predispose to resistance to chemotherapeutic agents, radiation, and hormonal cancer therapy. The analysis of the publications revealed the major markers of carcinogenesis that could potentially be used as biological targets for the design of modern diagnostic strategies and high-performance therapeutic protocols.

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Multistage Carcinogenesis: Cell and Animal Models

Cited by 4 publications

References 173 publications

miR‐4454 Promotes Hepatic Carcinoma Progression by Targeting Vps4A and Rab27A

miR‐4454 Promotes Hepatic Carcinoma Progression by Targeting Vps4A and Rab27A

Clove Essential Oil: Chemical Profile, Biological Activities, Encapsulation Strategies, and Food Applications

A modern look at the molecular-biological mechanisms of breast tumours in dogs

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